Tolerance during dose-increase phase of specific immunotherapy with standardized house-dust mite extract in asthmatic children

2007 ◽  
Vol &NA; ◽  
pp. S241
Author(s):  
Li Xiang ◽  
Hong-yan Zhang ◽  
Ji-mei Zhao ◽  
Jian-xin He ◽  
Kun-ling Shen
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Specific Immunotherapy ◽  
Dose Increase ◽  
Asthmatic Children ◽  
Mite Extract ◽  
Dust Mite ◽  
House Dust Mite Extract

scholarly journals Crucial role of stimulator of interferon genes-dependent signaling in house dust mite extract-induced IgE production

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hiroki Nunokawa ◽  
Yusuke Murakami ◽  
Takashi Ishii ◽  
Tomoya Narita ◽  
Haruyuki Ishii ◽  
...  
Keyword(s):  
B Cell ◽  
House Dust ◽  
House Dust Mite ◽  
Tfh Cells ◽  
Specific Serum ◽  
Mite Extract ◽  
Dust Mite ◽  
Cell Proportion ◽  
House Dust Mite Extract

AbstractStimulator of interferon genes (STING) is a DNA sensor that responds to pathogens and induces type I interferon production. Herein, the role of STING in house dust mite extract (HDM)-induced allergic asthma was investigated. C57BL/6 wild-type (WT) and Sting−/− mice were intratracheally sensitized with HDM, and the bronchoalveolar lavage fluid (BALF), sera, lungs, and mediastinal lymph nodes (MLNs) were analyzed. The total and HDM-specific serum IgE levels were lower in Sting−/− mice than in WT mice. B cell and IgE-positive B cell proportion in BALF and MLNs, respectively, was significantly lower in Sting−/− mice than in WT mice. Additionally, cyclic GMP-AMP, a STING ligand, augmented total and HDM-specific serum IgE levels and B cell proportion in BALF when applied in combination with HDM. To elucidate the role of STING in IgE production, follicular helper T (Tfh) cells, which are involved in B cell maturation, were investigated. Tfh cell proportion in MLNs decreased in Sting−/− mice, and IL-4 and IL-13 production by HDM-restimulated MLN cells from HDM-sensitized mice was decreased in Sting−/− mice compared with WT mice. Thus, STING plays an important role in the maturation and class switching of IgE-producing B cells in allergic inflammation via Tfh cells.

scholarly journals Oral immunotherapy with the ingestion of house dust mite extract in a murine model of allergic asthma

2018 ◽  
Vol 14 (1) ◽  
Author(s):  
Yao-Tung Wang ◽  
Hsu-Chung Liu ◽  
Hui-Chen Chen ◽  
Yen-Ching Lee ◽  
Tung-Chou Tsai ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Murine Model ◽  
Oral Immunotherapy ◽  
Mite Extract ◽  
Dust Mite ◽  
House Dust Mite Extract

scholarly journals House Dust Mite Extract Induces Interleukin-9 Expression in Human Eosinophils

2008 ◽  
Vol 57 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Takao Fujisawa ◽  
Hajime Katsumata ◽  
Yoshiko Kato
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Mite Extract ◽  
Dust Mite ◽  
Interleukin 9 ◽  
House Dust Mite Extract

scholarly journals Preventive sublingual immunotherapy with House Dust Mite extract modulates epitope diversity in pre‐school children

Allergy ◽  
2019 ◽  
Vol 74 (4) ◽  
pp. 780-787 ◽  
Author(s):  
Marta Ponce ◽  
Fabian Schroeder ◽  
Christina Bannert ◽  
Klara Schmidthaler ◽  
Christian Skjødt Hansen ◽  
...  
Keyword(s):  
School Children ◽  
House Dust ◽  
House Dust Mite ◽  
Sublingual Immunotherapy ◽  
Mite Extract ◽  
Dust Mite ◽  
House Dust Mite Extract
Sign in / Sign up

Export Citation Format

Share Document