Diagnostic Accuracy of Intracochlear Test Electrode for Acoustic Nerve Monitoring in Vestibular Schwannoma Surgery

Ear & Hearing ◽  
2020 ◽  
Vol 41 (6) ◽  
pp. 1648-1659
Author(s):  
María M. Medina ◽  
Rubén Polo ◽  
Emilio Amilibia ◽  
Francesc Roca-Ribas ◽  
Miguel Díaz ◽  
...  
2012 ◽  
Vol 73 (S 02) ◽  
Author(s):  
A. Kasbekar ◽  
Y. Tam ◽  
R. Carlyon ◽  
J. Deeks ◽  
N. Donnelly ◽  
...  

2007 ◽  
Vol 13 (1) ◽  
pp. 58-64 ◽  
Author(s):  
Enrico Piccirillo ◽  
Harukazu Hiraumi ◽  
Masashi Hamada ◽  
Alessandra Russo ◽  
Alessandro De Stefano ◽  
...  

2015 ◽  
Vol 66 (4) ◽  
pp. 192-198
Author(s):  
Jorge Vega-Céliz ◽  
Emili Amilibia-Cabeza ◽  
José Prades-Martí ◽  
Nuria Miró-Castillo ◽  
Marta Pérez-Grau ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ruiqing Long ◽  
Zhuohui Liu ◽  
Jinghui Li ◽  
Yuan Zhang ◽  
Hualin Yu

Abstract Background Vestibular schwannoma (VS) is a kind of benign tumor deriving from the acoustic nerve sheath. Substantial long non-coding RNAs (lncRNAs) were illustrated to have crucial roles in multiple cancers. However, few lncRNAs were elucidated in VS. Methods HCG11, miR-620 and ELK4 expression were tested by RT-qPCR. Gain-of-function experiments were conducted to confirm the effect of HCG11 on VS. Results HCG11 possessed a low expression in VS cell lines. Overexpression of HCG11 repressed cell proliferation but accelerated apoptosis of VS cells. Moreover, we identified ELK4 stimulated the transcription of HCG11 and their affinity was verified by ChIP assays. MiR-620 was chosen to be a target of HCG11 and it was tested to have a high expression in VS cell lines. Moreover, depletion of miR-620 could inhibit cell proliferative ability while fostering apoptosis rate of VS cells. ELK4 was low expressed in VS cell lines and knockdown of ELK4 could rescue the effects made by HCG11 overexpression on progression of VS. Conclusions HCG11 could inhibit the growth of VS by targeting miR-620/ELK4 in VS cells. HCG11 was a novel therapeutic target for VS treatment.


1998 ◽  
Vol 140 (3) ◽  
pp. 235-243 ◽  
Author(s):  
S.B. Sobottka ◽  
G. Schackert ◽  
S.A. May ◽  
M. Wiegleb ◽  
G. Reiß

2012 ◽  
Vol 33 (3) ◽  
pp. E5 ◽  
Author(s):  
Matthew L. Kircher ◽  
Jack M. Kartush

Despite the widespread acceptance of intraoperative neurophysiological monitoring in skull base surgery over the last 2 decades, surgeon training in the technical and interpretive aspects of nerve monitoring has been conspicuously lacking. Inadequate fundamental knowledge of neurophysiological monitoring may lead to misinterpretations and an inability to troubleshoot system errors. Some surgeons perform both the technical and interpretive aspects of monitoring themselves while others enjoin coworkers (surgical residents, nurses, anesthetists, or a separate monitoring service) to perform the technical portion. Regardless, the surgeon must have a thorough understanding to avoid potential medical and legal pitfalls because poor monitoring is worse than no monitoring. A structured curriculum and protocol in both the technical and interpretive aspects of monitoring is recommended for all personnel involved in the monitoring process. This paper details the technical, interpretive, and surgical correlates necessary for optimal intraoperative nerve monitoring during vestibular schwannoma surgery with an emphasis on electromyographic monitoring for facial and recurrent laryngeal nerves. Just as the American Society of Anesthesiologists' 1986 “Standards for Basic Anesthetic Monitoring” became a useful tool for both patients and anesthesiologists, impending guidelines in intraoperative neurophysiological monitoring should likewise become an important instrument for optimizing intraoperative neurophysiological monitoring.


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