scholarly journals Effects of Torsion on Intervertebral Disc Gene Expression and Biomechanics, Using a Rat Tail Model

Spine ◽  
2011 ◽  
Vol 36 (8) ◽  
pp. 607-614 ◽  
Author(s):  
Ana Barbir ◽  
Karolyn E. Godburn ◽  
Arthur J. Michalek ◽  
Alon Lai ◽  
Robert D. Monsey ◽  
...  
Keyword(s):  
Gene Expression ◽  
Intervertebral Disc ◽  
Rat Tail Model ◽  
Rat Tail

Reliability of radiographic intervertebral disc height measurement for in vivo rat-tail model

2007 ◽  
Vol 29 (7) ◽  
pp. 814-819 ◽  
Author(s):  
Alon Lai ◽  
Daniel H.K. Chow ◽  
W.S. Siu ◽  
Andrew D. Holmes ◽  
F.H. Tang
Keyword(s):  
Intervertebral Disc ◽  
Disc Height ◽  
Height Measurement ◽  
Intervertebral Disc Height ◽  
Rat Tail Model ◽  
Rat Tail

The effects of short-term load duration on anabolic and catabolic gene expression in the rat tail intervertebral disc

2005 ◽  
Vol 23 (5) ◽  
pp. 1120-1127 ◽  
Author(s):  
Jeffery J. Maclean ◽  
Cynthia R. Lee ◽  
Mauro Alini ◽  
James C. Iatridis
Keyword(s):  
Gene Expression ◽  
Intervertebral Disc ◽  
Catabolic Gene ◽  
Short Term ◽  
Load Duration ◽  
Rat Tail

scholarly journals Effect of Static Compression Loads on Intervertebral Disc: Anin VivoBent Rat Tail Model

2018 ◽  
Vol 10 (2) ◽  
pp. 134-143 ◽  
Author(s):  
Wei Xia ◽  
Lin-lin Zhang ◽  
Jun Mo ◽  
Wen Zhang ◽  
Hai-tao Li ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Static Compression ◽  
Rat Tail Model ◽  
Rat Tail

The Effect of Timing of rhBMP-2 Injection on Intervertebral Disc Degeneration in a Rat Tail Model

2012 ◽  
Vol 12 (9) ◽  
pp. S74
Author(s):  
Scott R. Montgomery ◽  
Hirokazu Inoue ◽  
Tuncay Kaner ◽  
Bayan G. Aghdasi ◽  
Yanlin Tan ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Rat Tail Model ◽  
Rat Tail

Effects of electroacupuncture on a degenerated intervertebral disc using an in-vivo rat-tail model

2008 ◽  
Vol 222 (2) ◽  
pp. 241-248 ◽  
Author(s):  
A Lai ◽  
D H K Chow ◽  
W-S Siu ◽  
A D Holmes ◽  
F-H Tang ◽  
...  
Keyword(s):  
Back Pain ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Biological Properties ◽  
Disc Height ◽  
Static Compression ◽  
Intervertebral Disc Height ◽  
Rat Tail Model ◽  
Rat Tail

Electroacupuncture (EA) has long been used as conservative treatment for low back pain (LBP). Its effect on relief of back pain has been demonstrated in many clinical studies. However, whether it has any effect on the biological properties of an intervertebral disc, which is one of the major causes of LBP, is still unclear. The aim of this study was, therefore, to investigate the effects of EA with different simulation frequencies on an intervertebral disc with simulated degeneration using an in-vivo rat-tail model. In this study, 33 rats were used. Disc degeneration was simulated in the rat caudal 8—9 disc via continuous static compressive loading of 11 N for 2 weeks. EA with a frequency of 2 or 100 Hz was then applied to the degenerated disc for 3 weeks with 3 sessions/week and 20 min/session. The intervertebral disc height was measured before and after compression as well as after EA intervention for 3 weeks. The static compression was found to result in a reduction in the disc height of about 22 per cent. There was no evidence that this change could be reversed after resting or the EA intervention. However, EA at 100 Hz was found to induce a further decrease in disc height, which was not shown for the rats after resting or EA at 2 Hz. The results of this study showed that effects of EA on disc degeneration are frequency dependent and adverse effects could result if EA at a certain frequency was used.

Compression-Induced Changes in Intervertebral Disc Properties in a Rat Tail Model

Spine ◽  
1999 ◽  
Vol 24 (10) ◽  
pp. 996-1002 ◽  
Author(s):  
James C. Iatridis ◽  
Peter L. Mente ◽  
Ian A. F. Stokes ◽  
David D. Aronsson ◽  
Mauro Alini
Keyword(s):  
Intervertebral Disc ◽  
Rat Tail Model ◽  
Induced Changes ◽  
Rat Tail

DNA Demethylation Regulates Anabolic and Catabolic Gene Expression in Intervertebral Disc Cells

2014 ◽  
Vol 4 (1_suppl) ◽  
pp. s-0034-1376587-s-0034-1376587
Author(s):  
N. Chutkan ◽  
R. Sangani ◽  
H. Zhou ◽  
S. Fulzele
Keyword(s):  
Gene Expression ◽  
Intervertebral Disc ◽  
Dna Demethylation ◽  
Catabolic Gene ◽  
Disc Cells
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