Who is the bad guy in acute respiratory distress syndrome? Neuronal nitric oxide synthase, inducible nitric oxide synthase, or both?*

2009 ◽  
Vol 37 (1) ◽  
pp. 363-364 ◽  
Author(s):  
Martin Westphal ◽  
Dirk M. Maybauer ◽  
Marc O. Maybauer
Keyword(s):  
Nitric Oxide ◽  
Acute Respiratory Distress Syndrome ◽  
Nitric Oxide Synthase ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Inducible Nitric Oxide Synthase ◽  
Distress Syndrome ◽  
Neuronal Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

REGULATORY ROLE OF NEURONAL NITRIC OXIDE SYNTHASE INHIBITION IN OVINE ACUTE RESPIRATORY DISTRESS SYNDROME.

2006 ◽  
Vol 34 ◽  
pp. A41
Author(s):  
Martin Westphal ◽  
Perenlei Enkhbaatar ◽  
Frank C Schmalstieg ◽  
Gabriela A Kulp ◽  
Lillian D Traber ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acute Respiratory Distress Syndrome ◽  
Nitric Oxide Synthase ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Neuronal Nitric Oxide Synthase ◽  
Regulatory Role ◽  
Oxide Synthase

scholarly journals A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Nevzat Selim Gokay ◽  
Ibrahim Yilmaz ◽  
Baran Komur ◽  
Ahu Senem Demiroz ◽  
Alper Gokce ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Cartilage Damage ◽  
Neuronal Nitric Oxide Synthase ◽  
Cartilage Regeneration ◽  
Nitric Oxide Synthase Inhibitor ◽  
Synthase Inhibitor ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

The objective of this study was to investigate the effects of selective inducible nitric oxide synthase and neuronal nitric oxide synthase inhibitors on cartilage regeneration. The study involved 27 Wistar rats that were divided into five groups. On Day 1, both knees of 3 rats were resected and placed in a formalin solution as a control group. The remaining 24 rats were separated into 4 groups, and their right knees were surgically damaged. Depending on the groups, the rats were injected with intra-articular normal saline solution, neuronal nitric oxide synthase inhibitor 7-nitroindazole (50 mg/kg), inducible nitric oxide synthase inhibitor amino-guanidine (30 mg/kg), or nitric oxide precursor L-arginine (200 mg/kg). After 21 days, the right and left knees of the rats were resected and placed in formalin solution. The samples were histopathologically examined by a blinded evaluator and scored on 8 parameters. Although selective neuronal nitric oxide synthase inhibition exhibited significant (P=0.044) positive effects on cartilage regeneration following cartilage damage, it was determined that inducible nitric oxide synthase inhibition had no statistically significant effect on cartilage regeneration. It was observed that the nitric oxide synthase activation triggered advanced arthrosis symptoms, such as osteophyte formation. The fact that selective neuronal nitric oxide synthase inhibitors were observed to have mitigating effects on the severity of the damage may, in the future, influence the development of new agents to be used in the treatment of cartilage disorders.

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