Novel saline injection technique for the reversal of the continuous costoclavicular block

The aim of this work was the development and validation of a fast analytical method to determine the residual solvents content in radiopharmaceuticals such as: 18F-Fluorodeoxyglucose (18F-FDG), 18F-Fluoroestradiol (18F-FES), 18F-Fluorothymidine (18F-FLT),18F-Fluoromisonidazole (18F-FMISO). Radiopharmaceuticals are radioactive preparations for medical purposes used in nuclear medicine as tracers in diagnostic imaging and treatment of certain diseases. Positron Emission Tomography (PET) is a medical imaging technique that consists in introducing into the body of a small amount of a biologically active chemical compound labelled with a short lived positron-emitting radioisotope (18F, 11C, 68Ga). Residual solvents are critical impurities in radiopharmaceuticals that can affect labelling, stability and physicochemical properties of drugs. Therefore, the determination of these solvents is essential for quality control of radiopharmaceuticals. Validation of the control method for residual solvents by gas chromatography is referred by the European Pharmacopoeia using a special injection technique (head space). The parameters of the method, which comply with International Conference on Harmonization guidelines, are: accuracy, precision, linearity, limit of detection, limit of quantification and robustness. The proposed method (direct gas chromatography injection) proved to be linear, precise, accurate and robust. Good linearity was achieved for all the solvents and correlation coefficients (R2) for each residual solvent were found more than 0.99.

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Comparison between Single- and Double-Injection Technique for Ultrasound-Guided Supraclavicular Block: A Randomized Controlled Study

Dubai Medical Journal ◽

10.1159/000517357 ◽

2021 ◽

pp. 1-6

Author(s):

Suresh Kumar Vallapureddy ◽

Gajanan Fultambkar ◽

V. Rajeswar Rao ◽

Vinay Kukreja ◽

Rammohan Gurram ◽

...

Keyword(s):

Brachial Plexus ◽

Local Anesthetic ◽

Motor Block ◽

Brachial Plexus Block ◽

Demographic Data ◽

Controlled Study ◽

Injection Technique ◽

Double Injection ◽

Performance Time ◽

Plexus Block

Background: The supraclavicular approach to brachial plexus block is a commonly employed regional anesthesia technique for providing surgical anesthesia and postoperative analgesia for patients undergoing upper limb fractures. With ultrasound (US) guidance, the success rate of the block is increased, and complications like pneumothorax and vascular puncture are minimized. The block can be performed using single injection at the corner pocket or double injection, that is, half of the drug at the corner pocket and the remaining half at the cluster of brachial plexus divisions. Methods: After institutional ethics committee approval, we randomized 40 patients scheduled with fractures for elective upper extremity surgery under US-guided supraclavicular brachial plexus block. Twenty patients received 30 mL of local anesthetic at the corner pocket (group SI), and 20 patients received 30 mL of local anesthetic using the dual-injection technique in divided doses (group DI). Demographic data, time to block performance, time to sensory and motor block, total anesthesia-related time (TART), block success, and failure were compared between both groups. Results: The demographic data were comparable between both groups. The DI group had a significantly faster onset than the SI group (p = 0.0172). There was a statistically significant lesser performance time in group SI than in group DI (p < 0.034). The sensory and motor block achieved was comparable between both groups. Conclusion: The success rates in both the SI and DI techniques are comparable. The DI technique results in a faster onset and hence a shorter TART; however, it may not be clinically relevant.

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Injection Technique Education in Patients with Diabetes Injecting Insulin into Areas of Lipohypertrophy: A Randomized Controlled Trial

Diabetes Therapy ◽

10.1007/s13300-021-01013-1 ◽

2021 ◽

Vol 12 (3) ◽

pp. 813-826

Author(s):

Liming Chen ◽

Qiuling Xing ◽

Jing Li ◽

Jianxin Zhou ◽

Yi Yuan ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Controlled Trial ◽

Injection Technique ◽

Randomized Controlled ◽

Patients With Diabetes

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Vascular anastomoses in intrauterine growth in monochorionic twins

Journal of Perinatal Medicine ◽

10.1515/jpm-2020-0028 ◽

2020 ◽

Vol 48 (6) ◽

pp. 539-543

Author(s):

Michał Lipa ◽

Przemysław Kosinski ◽

Paweł Stanirowski ◽

Mirosław Wielgos ◽

Dorota Bomba-Opon

Keyword(s):

Injection Technique ◽

Digital Analysis ◽

Monochorionic Twins ◽

Intrauterine Growth ◽

Blood Exchange ◽

Sharing Patterns ◽

A Prospective Study ◽

The Impact ◽

Umbilical Cords

AbstractObjectivesTo evaluate the impact of placental anastomoses on the intrauterine growth of monochorionic (MC) twins.MethodsA prospective study was conducted in a group of 53 MC twins. Intrapartally umbilical cords were clamped to identify placental sides corresponding to each twin. The postnatal dye injection technique was administered to evaluate vascular anastomoses, their number and type and visualize placental territory sharing patterns. Data from digital analysis were correlated with obstetrical follow-up.ResultsVascular anastomoses were revealed in 88.7% of cases. Arteriovenous (AV) anastomoses occurred in 75.4% and arterioarterial (AA) in 71.1% while venovenous (VV) in 26.4%. In the subgroup of MC twins without placental anastomoses, significantly higher birthweight difference and discordance were revealed when compared to MC twins without anastomoses (382.0 vs. 22 g; P = 0.03 and 49.14% vs. 16.02%; P = 0.03). On the other hand, in subgroups of MC twins with at least one AA anastomosis, twins’ birthweights were similar (p = ns) despite significantly higher placental territory sharing discordance (30.44% vs. 15.81%; P = 0.31).ConclusionsVascular anastomoses have a major impact on the intrauterine growth of MC twins. In certain cases, they may cause specific complications; however, in general, they regulate intertwin blood exchange and may compensate unequal placental territory.

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