Osseous Metaplasia and Mature Bone Formation With Extramedullary Hematopoiesis in Trichilemmal Cyst

2014 ◽  
Vol 36 (5) ◽  
pp. 444-446 ◽  
Author(s):  
Chiara Baldovini ◽  
Francesca Rosini ◽  
Gianluca Marucci
Keyword(s):  
Bone Formation ◽  
Extramedullary Hematopoiesis ◽  
Osseous Metaplasia ◽  
Trichilemmal Cyst ◽  
Mature Bone

scholarly journals Gastric gastrointestinal stromal tumor with osseous differentiation and stromal calcification: A case report and review of literature

2017 ◽  
Vol 5 ◽  
pp. 2050313X1774631 ◽  
Author(s):  
Haneen Al-Maghrabi ◽  
Abdelrazak Meliti
Keyword(s):  
Case Report ◽  
Bone Formation ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Gastric Wall ◽  
Stromal Tumor ◽  
Osseous Metaplasia ◽  
Gastrointestinal Malignancies ◽  
Stromal Tumors ◽  
Mature Bone

Gastrointestinal stromal tumors are the most common primary mesenchymal tumors of the gastrointestinal tract accounting for 0.1%–3.0% of all gastrointestinal malignancies. The stomach is the most common site (60%) followed by the small bowel (30%–35%) particularly jejunum and ileum, colorectum (5%) and rarely affect esophagus and appendix. Most gastrointestinal stromal tumors arise sporadically, however, less commonly they develop in association with various clinical syndromes like Carney triad, Carney–Stratakis syndrome, familial gastrointestinal stromal tumor syndrome and neurofibromatosis type1 (NF1). We report a 65-year-old male patient presented with gastric mass (7.5 × 4.5 × 3.5 cm) arising from the posterior gastric wall. Histologic examination revealed neoplastic proliferation of spindled and epithelioid cells with focal plexiform pattern and low mitotic activity 3/50 HPF. No evidence of cytological atypia, abnormal mitosis or necrosis. Interestingly enough, there were focal areas of mature bone formation/osseous differentiation associated with calcification. The tumor cells were strongly positive for CD117, DOG1 with focal immunoreactivity against CD34. The morphologic features and the immunoprofile were diagnostic of gastrointestinal stromal tumor. Herein, we present a rare case of gastric gastrointestinal stromal tumor with mature bone formation, osseous metaplasia and calcification. To the best of our knowledge, this is the second case report of gastric gastrointestinal stromal tumor with osseous differentiation and mature bone formation.

scholarly journals Osseous metaplasia with mature bone formation of the thyroid gland: Three case reports

2013 ◽  
Vol 6 (4) ◽  
pp. 977-979 ◽  
Author(s):  
JI-SUN CHUN ◽  
RAN HONG ◽  
JUNG-A KIM
Keyword(s):  
Thyroid Gland ◽  
Bone Formation ◽  
Case Reports ◽  
Osseous Metaplasia ◽  
Mature Bone

scholarly journals Platelet-rich plasma decreases fibroblastic activity and woven bone formation with no significant immunohistochemical effect on long-bone healing: An experimental animal study with radiological outcomes

2018 ◽  
Vol 26 (3) ◽  
pp. 230949901880249 ◽  
Author(s):  
İbrahim Deniz Canbeyli ◽  
Rahmi Can Akgun ◽  
Orcun Sahin ◽  
Aysen Terzi ◽  
İsmail Cengiz Tuncay
Keyword(s):  
Bone Formation ◽  
Callus Formation ◽  
Platelet Rich Plasma ◽  
Long Bone ◽  
Proliferation Index ◽  
Fibroblast Proliferation ◽  
Ki 67 ◽  
Woven Bone ◽  
Group B ◽  
Mature Bone

Purpose: This study aimed to analyze the immunohistochemical effect of platelet-rich plasma (PRP) on healing of long-bone fractures in terms of bone morphogenetic protein-2 (BMP-2), vascular endothelial growth factor (VEGF), the Ki-67 proliferation index, and radiological and histological analyses. Methods: Sixteen adult rabbits, whose right femoral diaphysis was fractured and fixed with Kirschner wires, were randomly divided into two groups, control and PRP (groups A and B, respectively). PRP was given to group B at 1 week postoperatively, and all animals were euthanized after 12 weeks. Radiographic evaluations were performed periodically. Cortical callus formation, chondroid and woven bone area percentages, osteoblastic and fibroblastic activities, and mature bone formation were examined. The depths of BMP-2 and VEGF staining were measured. The Ki-67 proliferation index was also calculated. Results: The mean radiological union score of group B was significantly higher than that of group A. There were also statistically significant differences between groups A and B in terms of cortical callus formation, woven bone area percentage, fibroblast proliferation, and mature bone formation. Group B had significantly more cortical callus and mature bone formation with less woven bone and fibroblast proliferation. Immunohistochemical analysis revealed no statistically significant difference between the groups in terms of BMP-2 and VEGF staining and the Ki-67 index. Conclusions: PRP had no effect on BMP-2 or VEGF levels with no increase in the Ki-67 proliferation index, although its application had a positive effect on bone healing by increasing callus and mature bone formation with decreased woven bone and fibroblast proliferation.

A case of osseous metaplasia in a gastric hyperplastic polyp: An unexpected finding in a common polyp

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S69-S70
Author(s):  
Y Zhang ◽  
Y Nakanishi
Keyword(s):  
Bone Formation ◽  
Hyperplastic Polyp ◽  
Case Reports ◽  
Osseous Metaplasia ◽  
Heterotopic Bone ◽  
Heterotopic Bone Formation ◽  
Hyperplastic Polyps ◽  
History Of ◽  
Acute And Chronic Inflammation ◽  
Gastric Hyperplastic Polyp

Abstract Introduction/Objective Foveolar hyperplastic polyp is a common gastric polyp characterized by foveolar hyperplasia with erosion, acute and chronic inflammation, granulation tissue formation, and smooth muscle strands extending from the muscularis mucosae. Although foveolar hyperplastic polyps may rarely contain foci of dysplasia or invasive carcinoma, osseous metaplasia/heterotopic bone formation in foveolar hyperplastic polyps of the stomach is extremely rare with a few case reports. Methods/Case Report A 63-year-old female with a history of hypertension, sick sinus syndrome, and Hashimoto’s thyroiditis was referred to our facility for evaluation of a mass in segment eight of the liver. The liver biopsy showed a moderately differentiated adenocarcinoma, most consistent with intrahepatic cholangiocarcinoma. A screening gastrointestinal endoscopy revealed a 7-mm sessile polyp in the antrum. The polyp was removed with a cold snare. No other abnormalities were identified in the stomach. Sections of the polyp showed fragments of antral-type gastric mucosa with foveolar hyperplasia, erosion, acute and chronic inflammation, and focal granulation tissue formation. In addition, multiple foci of woven bone formation without bone marrow surrounding dilated gastric foveolae were identified. No Helicobacter infection, intestinal metaplasia, dysplasia or malignancy was identified histologically. Osseous metaplasia/heterotopic bone formation is a well-known finding reported in various neoplastic and non- neoplastic conditions. However, osseous metaplasia in foveolar hyperplastic polyps of the stomach is extremely rare. There have been only four previous case reports published in English language. Our current case shows clinicopathologic features similar to those of the previous case reports including the findings of small-sized polyp found incidentally in middle-aged patients with no clinical history of hypercalcemia or any other abnormalities causing heterotopic bone formation. Results (if a Case Study enter NA) N/A Conclusion Although the pathogenesis of osseous metaplasia in a gastric hyperplastic polyp remains unknown, the finding of osseous metaplasia in a gastric hyperplastic polyp is very intriguing.

scholarly journals RENAL CELL CARCINOMA WITH OSSEOUS METAPLASIA OCCURRING IN A CONTRACTED KIDNEY - A RARE CASE REPORT

2013 ◽  
Vol 03 (04) ◽  
pp. 137-138
Author(s):  
Harish S. Permi
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Bone Formation ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Significance ◽  
Good Prognosis ◽  
Osseous Metaplasia ◽  
Tumor Spread ◽  
Metaplastic Bone

AbstractOsseous metaplasia is a rare histologic feature associated with renal cell carcinoma, occurring in a contracted kidney is still rarer. Metaplastic bone formation within the renal tumor gives an appearance similar to that of calcification. It is difficult to distinguish between bone formation and calcification on the basis of radiological imaging alone. Prognostic significance of metaplastic bone formation in renal cell carcinoma is not clear, however some report suggest good prognosis as a result of limitation of tumor spread by bone formation. This case report highlights the occurrence of renal cell carcinoma with osseous metaplasia in a contracted kidney.

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