Somatic Mutation Profile of Atypical Fibroxanthoma and Cutaneous Undifferentiated Pleomorphic Sarcoma

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Young H. Lim ◽  
Theodore D. Zaki ◽  
Jonathan L. Levinsohn ◽  
Anjela Galan ◽  
Keith A. Choate ◽  
...  
Keyword(s):  
Somatic Mutation ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Atypical Fibroxanthoma ◽  
Pleomorphic Sarcoma ◽  
Mutation Profile

Atypical Fibroxanthoma

2016 ◽  
Vol 140 (4) ◽  
pp. 376-379 ◽  
Author(s):  
Liurka López ◽  
Román Vélez
Keyword(s):  
Standard Of Care ◽  
Skin Tumor ◽  
Surgical Removal ◽  
Genetic Studies ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Atypical Fibroxanthoma ◽  
Pleomorphic Sarcoma ◽  
Malignant Skin ◽  
Abundant Cytoplasm ◽  
The Difference

Atypical fibroxanthoma is a malignant skin tumor with histologic features similar to those of undifferentiated pleomorphic sarcoma, but lacking its more aggressive behavior. The tumor is composed of pleomorphic cells with hyperchromatic nuclei and abundant cytoplasm, commonly arranged in a spindle cell pattern. Recent genetic studies have identified similarities between atypical fibroxanthoma and undifferentiated pleomorphic sarcoma, such as the presence of 9p and 13q deletions in both tumors, favoring a common histogenesis. However, the lack of K-ras and H-ras mutations in atypical fibroxanthoma compared with undifferentiated pleomorphic sarcoma could explain the difference in aggressiveness and continued separation of these entities. Exclusion of other neoplasms by histology and immunohistochemistry followed by complete surgical removal remains the standard of care.

Aberrant Melan-A expression in atypical fibroxanthoma and undifferentiated pleomorphic sarcoma of the skin

2011 ◽  
Vol 38 (12) ◽  
pp. 954-960 ◽  
Author(s):  
Chee Thum ◽  
Kevin Hollowood ◽  
Jeremy Birch ◽  
John R. Goodlad ◽  
Thomas Brenn
Keyword(s):  
Undifferentiated Pleomorphic Sarcoma ◽  
Atypical Fibroxanthoma ◽  
Pleomorphic Sarcoma

Reconsidering the Diagnostic and Prognostic Utility of LN-2 for Undifferentiated Pleomorphic Sarcoma and Atypical Fibroxanthoma

2013 ◽  
Vol 35 (2) ◽  
pp. 176-179 ◽  
Author(s):  
S. Tyler Hollmig ◽  
Kerri E. Rieger ◽  
Michael T. Henderson ◽  
Robert B. West ◽  
Uma N. Sundram
Keyword(s):  
Undifferentiated Pleomorphic Sarcoma ◽  
Atypical Fibroxanthoma ◽  
Pleomorphic Sarcoma ◽  
Prognostic Utility
Sign in / Sign up

Export Citation Format

Share Document