Fractional Ablative Laser-Assisted Delivery of Topical Poly-L-lactic Acid

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jordan V. Wang ◽  
Nkemjika Ugonabo ◽  
Roy G. Geronemus
2010 ◽  
Vol 30 (3) ◽  
pp. 457-464 ◽  
Author(s):  
J. P. Farkas ◽  
J. A. Richardson ◽  
C. F. Burrus ◽  
J. E. Hoopman ◽  
S. A. Brown ◽  
...  

2021 ◽  
Vol 10 (5) ◽  
pp. 253-259
Author(s):  
Agnieszka Surgiel-Gemza ◽  
◽  
Krzysztof Gemza ◽  
◽  
◽  
...  

Stretch marks are a common problem and a challenge for cosmetologists and aesthetic medicine doctors. Due to the complex etiopathogenesis and difficulties in their reduction, specialists use various therapeutic methods. In this study, the described case confirms the effectiveness of selected combined therapy in reducing stretch marks and skin laxity. Impressive surgical results were obtained with the implementation of combined therapy consisting of the use of non-ablative Nd:YAG fractional laser and alexandrite laser in picosecond technology, CO2 fractional ablative laser and needle mesotherapy treatments.


2021 ◽  
Vol 12 (2) ◽  
pp. 133-144
Author(s):  
Deepal Vora ◽  
Yujin Kim ◽  
Ajay K Banga

Aim: Our study investigated the feasibility of transdermal delivery of heparin, an anticoagulant used against venous thromboembolism, as an alternative to intravenous administration. Materials & methods: Skin was pretreated using ablative laser (Precise Laser Epidermal System [P.L.E.A.S.E.®] technology) for enhanced delivery of heparin. In vitro permeation studies using static Franz diffusion cells provided a comparison between delivery from 0.3% w/v heparin-loaded poloxamer gel and solution across untreated and laser-treated dermatomed porcine ear skin. Results: No passive delivery of heparin was observed. Laser-assisted delivery from solution (26.07 ± 1.82 μg/cm2) was higher (p < 0.05) than delivery from heparin gel (11.28 ± 5.32 μg/cm2). However, gel is likely to sustain the delivery over prolonged periods like a maintenance dose via continuous intravenous infusion. Conclusion: Thus, ablative laser pretreatment successfully delivered heparin, establishing the feasibility of delivering hydrophilic macromolecules using the transdermal route.


2020 ◽  
Vol 41 (Supplement_1) ◽  
pp. S74-S75
Author(s):  
Taryn E Travis ◽  
Rebekah R Allely ◽  
Laura S Johnson ◽  
Jeffrey W Shupp

Abstract Introduction Fractional ablative laser therapy use is increasing for treating burn hypertrophic scar (HTS). However, standard components of a routine HTS evaluation prior to starting laser scar revision (LSR) and after each intervention have yet to be determined, and metrics for effective treatment have not been established. Methods Patients who entered a LSR program between September 2018 and September 2019, underwent at least two LSR treatments, and completed post-LSR scar evaluations for each of these treatments were included in the studied sample. Patients were treated with a fractional ablative CO2 laser. A single burn rehabilitation therapist conducted all pre- and post-procedure scar evaluations, which included the Patient and Observer Scar Assessment Scale (POSAS), Vancouver Scar Scale (VSS), Institutional Scar Comparison Scale (SCS), durometry, and active range of motion (AROM) measurements. Results From 9/2018 to 9/2019, 25 patients began the LSR program and underwent at least two treatments with post-laser scar assessments for each intervention. Patients underwent an average of 3±1 LSR sessions during the time period for a total of 84 sessions amongst the group. Patients averaged 51±14 years old (range 26–80), with all Fitzpatrick skin types represented (mode type 5). Average HTS age was 14±19 months post-injury (range 3–98 months post injury). After one session of LSR, 91% of patients improved in at least one scar assessment metric (average 3±1.4 areas). After two sessions, all patients showed improvement in at least one metric (average 3.6±1.2 areas). One LSR session was associated with a 10.8±31.9% improvement in AROM of a HTS-affected joint, and this increased to 38.1±41.4% after five LSR treatments (p=0.0002). Durometry readings demonstrated decreasing scar hardness compared to adjacent uninjured skin in 90% of patients, and 96% of patients experienced improvements in POSAS, VSS, and SCS scores during a treatment course. Conclusions Improvements in burn HTS can be achieved with fractional ablative laser therapy in a wide range of scar ages and skin types, as early as the first LSR session. These continue to increase as additional sessions are performed. Applicability of Research to Practice This work suggests necessary baseline evaluation components for patients undergoing LSR, as well as a timeline for expected clinical improvements. This data may inform conversations with burn survivors and providers when considering laser therapy for symptomatic HTS.


2012 ◽  
Vol 3 (3) ◽  
pp. 188-195
Author(s):  
Nagat Sobhy ◽  
El-Shafaei Adel ◽  
Nanis Kamal

2018 ◽  
Vol 21 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Mouna Korbi ◽  
Hayet Akkari ◽  
Yosra Soua ◽  
Mariem Mohamed ◽  
Monia Youssef ◽  
...  

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