Perils of Antithrombotic Transitions: Effect of Oral Factor Xa Inhibitors on the Heparin Antifactor Xa Assay

2020 ◽  
Vol 42 (5) ◽  
pp. 737-743
Author(s):  
Tania Ahuja ◽  
Irene Yang ◽  
Quy Huynh ◽  
John Papadopoulos ◽  
David Green
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Antifactor Xa

Comparison of the Anticoagulant and Antithrombotic Effects of Synthetic Thrombin and Factor Xa Inhibitors

1990 ◽  
Vol 63 (02) ◽  
pp. 220-223 ◽  
Author(s):  
J Hauptmann ◽  
B Kaiser ◽  
G Nowak ◽  
J Stürzebecher ◽  
F Markwardt
Keyword(s):  
Factor Xa ◽  
Thrombin Inhibitors ◽  
Factor Xa Inhibitors ◽  
Venous Stasis ◽  
Clotting Time ◽  
Thrombosis Model ◽  
Activity Factor ◽  
Antithrombotic Effects

SummaryThe anticoagulant effect of selected synthetic inhibitors of thrombin and factor Xa was studied in vitro in commonly used clotting assays. The concentrations of the compounds doubling the clotting time in the various assays were mainly dependent on their thrombin inhibitory activity. Factor Xa inhibitors were somewhat more effective in prolonging the prothrombin time compared to the activated partial thromboplastin time, whereas the opposite was true of thrombin inhibitors.In vivo, in a venous stasis thrombosis model and a thromboplastin-induced microthrombosis model in rats the thrombin inhibitors were effective antithrombotically whereas factor Xa inhibitors of numerically similar IQ value for the respective enzyme were not effective at equimolar dosageThe results are discussed in the light of the different prelequisiles and conditions for inhibition of thrombin and factor Xa in the course of blood clotting.

Analyses of Activity for Factor Xa Inhibitors Based on Monte Carlo Simulations

2003 ◽  
Vol 46 (26) ◽  
pp. 5691-5699 ◽  
Author(s):  
Dennis Ostrovsky ◽  
Marina Udier-Blagović ◽  
William L. Jorgensen
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Factor Xa ◽  
Factor Xa Inhibitors

An optimised, rapid chromogenic assay, specific for measuring direct factor Xa inhibitors (rivaroxaban) in plasma

2010 ◽  
Vol 104 (11) ◽  
pp. 1078-1079 ◽  
Author(s):  
Jean Amiral ◽  
Céline Guinet ◽  
Elisabeth Perzborn ◽  
François Depasse ◽  
Meyer Michel Samama
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Direct Factor ◽  
Chromogenic Assay ◽  
Direct Factor Xa Inhibitors

Sulfonamidopyrrolidinone Factor Xa Inhibitors:  Potency and Selectivity Enhancements via P-1 and P-4 Optimization

1999 ◽  
Vol 42 (18) ◽  
pp. 3572-3587 ◽  
Author(s):  
Yong Mi Choi-Sledeski ◽  
Daniel G. McGarry ◽  
Daniel M. Green ◽  
Helen J. Mason ◽  
Michael R. Becker ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors
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