scholarly journals The evolution of molecular ruler analysis for characterizing telomere imbalances: from fluoresence in situ hybridization to array comparative genomic hybridization

2007 ◽  
Vol 9 (9) ◽  
pp. 566-573 ◽  
Author(s):  
Christa Lese Martin ◽  
Zafar Nawaz ◽  
Erin L Baldwin ◽  
Elijah J Wallace ◽  
April N Justice ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Comparative Genomic Hybridization ◽  
Array Comparative Genomic Hybridization ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Molecular Ruler

Fluorescent In Situ Hybridization and Array Comparative Genomic Hybridization: Complementary Techniques for Genomic Evaluation

2006 ◽  
Vol 130 (7) ◽  
pp. 967-974
Author(s):  
Carl Morrison
Keyword(s):  
In Situ Hybridization ◽  
Comparative Genomic Hybridization ◽  
Fluorescent In Situ Hybridization ◽  
Array Comparative Genomic Hybridization ◽  
Daily Practice ◽  
Molecular Techniques ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Expression Arrays

Abstract During the past few years a new high-throughput molecular technology, array comparative genomic hybridization, has received a great deal of attention. As a DNA-based tool, this technique is presumably more reproducible than expression arrays. In this review, I discuss how array comparative genomic hybridization is remarkably similar with regard to genome analysis to fluorescent in situ hybridization, a technique that is generally regarded as one of the more accurate and reproducible molecular techniques in diagnostic surgical pathology. A thorough understanding of this technology will be useful for all surgical pathologists in the near future, as this technology will no doubt have some influence on our daily practice.

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