scholarly journals Nerve Transfers—A Paradigm Shift in the Reconstructive Ladder

2019 ◽  
Vol 7 (6) ◽  
pp. e2290 ◽  
Author(s):  
Leahthan F. Domeshek ◽  
Christine B. Novak ◽  
J. Megan M. Patterson ◽  
Jessica M. Hasak ◽  
Andrew Yee ◽  
...  
2019 ◽  
Vol 52 (03) ◽  
pp. 277-284
Author(s):  
Mohit Sharma ◽  
Subramania Iyer ◽  
Kishore Purushottaman ◽  
Sundeep Vijayaraghavan ◽  
Jimmy Matthew ◽  
...  

Abstract Introduction Vascularized composite allotransplantation (VCA) has added another step to the reconstructive ladder, leading to a paradigm shift in the approach toward management of cases of upper limb amputations. In this article, we discuss in detail the technical aspects of proximal forearm level transplantation, as well as the immediate posttransplant monitoring and immunosuppression protocols. Materials and Methods A 24-year-old male victim of an electric injury presented with a bilateral proximal forearm level amputation. After the mandatory preoperative psychiatric and immunological evaluation, the patient underwent a proximal forearm level double upper extremity transplantation. He was then put on a stringent immunosuppression and physical rehabilitative regime. Discussion Conceptually, the proximal forearm level transplantation is significantly different from distal forearm level transplant. This transplant “reestablishes” the “donor extremity length,” maintains the normal functional length of the donor muscles, and the functional return happens only after the newly transplanted donor muscles are reinnervated over a period of time. Conclusion As the sequence of surgical repair and associated decision making could be quite confusing for this level of transplantation, it is highly advisable to do mock cadaver surgical dissections in order to standardize the procedure and make the team familiar with it.


1985 ◽  
Vol 30 (1) ◽  
pp. 17-17
Author(s):  
Marion Perlmutter
Keyword(s):  

1994 ◽  
Vol 39 (2) ◽  
pp. 197-198
Author(s):  
Raymond T. Garza
Keyword(s):  

2011 ◽  
Author(s):  
Wendy L. Bedwell ◽  
Aaron S. Dietz ◽  
Kathryn E. Keeton ◽  
Daniel Tani ◽  
Gerald Goodwin ◽  
...  
Keyword(s):  

2016 ◽  
Vol 04 (01) ◽  
pp. 4-10

AbstractImmunosuppression permits graft survival after transplantation and consequently a longer and better life. On the other hand, it increases the risk of infection, for instance with cytomegalovirus (CMV). However, the various available immunosuppressive therapies differ in this regard. One of the first clinical trials using de novo everolimus after kidney transplantation [1] already revealed a considerably lower incidence of CMV infection in the everolimus arms than in the mycophenolate mofetil (MMF) arm. This result was repeatedly confirmed in later studies [2–4]. Everolimus is now considered a substance with antiviral properties. This article is based on the expert meeting “Posttransplant CMV infection and the role of immunosuppression”. The expert panel called for a paradigm shift: In a CMV prevention strategy the targeted selection of the immunosuppressive therapy is also a key element. For patients with elevated risk of CMV, mTOR inhibitor-based immunosuppression is advantageous as it is associated with a significantly lower incidence of CMV events.


2005 ◽  
Vol 21 (07) ◽  
Author(s):  
Hakim Said ◽  
Todd Kuiken ◽  
Robert Lipzchutz ◽  
Laura Miller ◽  
Gregory Dumanian

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