Treatment of Advanced Basal Cell Carcinoma with Hedgehog Pathway Inhibitors: A Multidisciplinary Expert Meeting

Despite recent progress and the publishing of several clinical guidelines on the management of advanced basal cell carcinoma, there is still no comprehensive set of clinical guidelines addressing the complexity inherent to the use of Hedgehog pathway inhibitors in the treatment of advanced basal cell carcinoma in real-world clinical practice. To develop practical and valuable tools that help specialists improve the clinical management of these patients, we sought the opinion of expert physicians with extensive knowledge and experience in the treatment of advanced basal cell carcinoma.

REBRANDING BADAN KEPENDUDUKAN DAN KELUARGA BERENCANA NASIONAL DALAM MENYASAR GENERASI MILLENIAL DAN ZILLENIAL

Penelitian ini bertujuan untuk mendeskripsikan proses rebranding Badan Kependudukan dan Keluarga Berencana Nasional (BKKBN) dengan menggunakan metode penelitian deskriptif kualitatif. Teknik pengumpukan data dilakukan dengan cara studi dokumen dan observasi dengan terjun langsung di lapangan. Hasil penelitian menunjukkan bahwa rebranding BKKBN sudah dimulai pada tahun 2009 pascareformasi atau setelah diterapkannya Otonomi Daerah di Indonesia. Namun pada tahun 2019 BKKBN menginisiasikan formalitas rebranding dalam peraturan lembaga. Penelitian ini menjelaskan secara detail pelaksanaan rebranding BKKBN dengan melakukan empat elemen rebranding yaitu repositioning, renaming, redesign, dan relaunch. Hasil penelitian menunjukkan bahwa repositioning BKKBN dilakukan dengan menentukan target segmentasi audiens BKKBN yang berfokus pada generasi millenial dan zillenial serta mengubah posisi BKKBN dari isu fertilitas menjadi “Sahabat Keluarga”. Pada proses renaming BKKBN tidak mengubah namanya karena UU No. 52 Tahun 2009 masih relevan sehingga yang diganti hanyalah visi dan misi BKKBN agar lebih relatable dengan kondisi saat ini. Pada tahap redesign BKKBN melibatkan publik dengan mengadakan lomba logo, tagline, dan jingle, expert meeting serta pre-testing hasil lomba. Logo baru BKKBN berbentuk hati, kupu-kupu dan berwarna biru, tagline BKKBN adalah “Berencana itu Keren”. Proses relaunch menemui banyak hambatan dari pengunduran karena pematangan konsep logo, tagline, dan theme song serta pandemi Covid-19. Soft launching pemenang jingle lomba dan aransemen ulang Mars KB diadakan pada 19 Desember 2019. Peluncuran logo baru BKKBN dilakukan di internal BKKBN, seluruh media sosial @BKKBNOfficial dan penyebarluasan siaran pers. Terakhir Grand launching rebranding diadakan berbarengan dengan Hari Keluarga Nasional ke-XXVI pada 29 Juni 2020. Kata kunci: rebranding, komunikasi, BKKBN, brand image

A Five-Step Stakeholder Communication Plan for More Effective Natural Resource Management

Effectively communicating with diverse groups involved in environmental management is critical to facilitating successful projects. This five-step communication plan is designed to enable resource managers and extension professionals to successfully engage their stakeholders. This plan, which uses oyster reef management as an example, was informed by two primary sources: an expert meeting with stakeholder leaders and coastal res- idents and a review of relevant literature. By incorporating stakeholder input throughout the planning and imple- mentation of natural resource management projects, new and innovative ideas emerge, and relationships between stakeholders, managers, and extension agents are strengthened.

Prevention and Control of COVID-19 in Imperfect Condition: Practical Guidelines for Nursing Homes by Japan Environment and Health Safety Organization (JEHSO)

Infection control at nursing homes is a top priority to address the COVID-19 pandemic because people who are the most vulnerable to the pathogen live in close contact. Currently, control measures specifically for nursing homes often ignore under-resourced condition of the facilities. To make guidelines assuming realistic conditions, an expert meeting with 16 members established the key challenges in nursing homes, the basics of infection control, and the major transmission routes. A list of existing guidance was compiled and each item in the list was peer-reviewed by eight experts considering three aspects: significance, scientific validity, and feasibility. Factors related to the nursing home environment, the nature of SARS-CoV-2 transmission, and patient characteristics were identified as the causes of difficulties in infection control at nursing homes. To develop realistic prevention measures in under-resourced condition such as nursing homes, we may need to accept there are no perfect control measures that can achieve zero risk. Instead, the guidelines are based on the concept of deep defense, and practical checklists with 75 items were established. The evaluation of nursing homes by independent organizations using the checklists would be helpful to achieve sustainable infection control.

Cancer survivors’ views on digital support for smoking cessation and alcohol moderation: a survey and qualitative study

Background Digital interventions may provide low-threshold support for smoking cessation (SC) and alcohol moderation (AM) to the growing population of cancer survivors. The objective was to explore preconditions of successful AM and SC digital interventions for cancer survivors. Methods Using a multi-method approach we conducted a survey (n = 240), a qualitative study consisting of four focus groups (n = 15) and semi-structured interviews with Dutch cancer survivors (n = 8). To help interpretation of our results we interviewed experts in the field of eHealth and cancer survivors (n = 6) and we organized an expert meeting (n = 7). Qualitative data were analysed using the Framework approach and were double-coded by two coders. Results Survey results show the majority of drinkers had not previously considered AM (n = 158, 84.9%), often because they deemed their alcohol use to be non-problematic. All current smokers in the survey had considered SC before. In focus groups and interviews it became clear that SC efforts did not always stem from their own willingness to quit smoking, but originated from a wish to please their social environment. Main themes to be addressed in digital SC and AM that emerged from the interviews and focus groups, centred on the different ways of identification as cancer survivors, need for autonomy, differential beliefs about SC and AM, and the importance of a positive, non-patronizing tone-of-voice. Several specific preferences for digital interventions were formulated, although some cancer survivors prefer no support or face-to-face contact. Conclusions Cancer survivors are a diverse group with diverse preferences for AM and SC support. Digital AM and SC interventions for cancer survivors are perceived to be of value by some, especially when they incorporate a positive, non-judgemental and non-patronizing tone-of-voice, address concerns specifically relevant to cancer survivors, offer possibilities for personalization, and emphasize autonomy throughout. To encourage AM specifically, problem recognition and awareness of the health benefits of AM should be improved.

Targeting DNA Damage Repair Mechanisms in Pancreas Cancer

Impaired DNA damage repair (DDR) is increasingly recognised as a hallmark in pancreatic ductal adenocarcinoma (PDAC). It is estimated that around 14% of human PDACs harbour mutations in genes involved in DDR, including, amongst others, BRCA1/2, PALB2, ATM, MSH2, MSH6 and MLH1. Recently, DDR intervention by PARP inhibitor therapy has demonstrated effectiveness in germline BRCA1/2-mutated PDAC. Extending this outcome to the significant proportion of human PDACs with somatic or germline mutations in DDR genes beyond BRCA1/2 might be beneficial, but there is a lack of data, and consequently, no clear recommendations are provided in the field. Therefore, an expert panel was invited by the European Society of Digestive Oncology (ESDO) to assess the current knowledge and significance of DDR as a target in PDAC treatment. The aim of this virtual, international expert meeting was to elaborate a set of consensus recommendations on testing, diagnosis and treatment of PDAC patients with alterations in DDR pathways. Ahead of the meeting, experts completed a 27-question survey evaluating the key issues. The final recommendations herein should aid in facilitating clinical practice decisions on the management of DDR-deficient PDAC.