Arterial stiffness, cardiovagal baroreflex sensitivity and postural blood pressure changes in older adults: The Rotterdam Study

2007 ◽  
Vol 25 (7) ◽  
pp. 1421-1426 ◽  
Author(s):  
Francesco US Mattace-Raso ◽  
Anton H van den Meiracker ◽  
Willem Jan Bos ◽  
Tischa JM van der Cammen ◽  
Berend E Westerhof ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Arterial Stiffness ◽  
Baroreflex Sensitivity ◽  
Rotterdam Study ◽  
Pressure Changes

Arterial stiffness as the candidate underlying mechanism for postural blood pressure changes and orthostatic hypotension in older adults: the Rotterdam Study

2006 ◽  
Vol 24 (2) ◽  
pp. 339-344 ◽  
Author(s):  
Francesco US Mattace-Raso ◽  
Tischa JM van der Cammen ◽  
Anneke M Knetsch ◽  
Anton H van den Meiracker ◽  
Maarten ADH Schalekamp ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Arterial Stiffness ◽  
Orthostatic Hypotension ◽  
Underlying Mechanism ◽  
Rotterdam Study ◽  
Pressure Changes

scholarly journals Insertion/deletion gene polymorphism of the angiotensin-converting enzyme and blood pressure changes in older adults. The Rotterdam study

2007 ◽  
Vol 21 (9) ◽  
pp. 736-740 ◽  
Author(s):  
F U S Mattace-Raso ◽  
M P S Sie ◽  
T J M van der Cammen ◽  
M E Safar ◽  
A Hofman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Rotterdam Study ◽  
Pressure Changes

scholarly journals Time‐Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above‐Normal Blood Pressure

2021 ◽  
Author(s):  
Daniel H. Craighead ◽  
Thomas C. Heinbockel ◽  
Kaitlin A. Freeberg ◽  
Matthew J. Rossman ◽  
Rachel A. Jackman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Muscle Strength ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Systolic Blood Pressure ◽  
High Resistance ◽  
Maximal Inspiratory Pressure ◽  
No Bioavailability ◽  
Inspiratory Muscle Strength

Background High‐resistance inspiratory muscle strength training (IMST) is a novel, time‐efficient physical training modality. Methods and Results We performed a double‐blind, randomized, sham‐controlled trial to investigate whether 6 weeks of IMST (30 breaths/day, 6 days/week) improves blood pressure, endothelial function, and arterial stiffness in midlife/older adults (aged 50–79 years) with systolic blood pressure ≥120 mm Hg, while also investigating potential mechanisms and long‐lasting effects. Thirty‐six participants completed high‐resistance IMST (75% maximal inspiratory pressure, n=18) or low‐resistance sham training (15% maximal inspiratory pressure, n=18). IMST was safe, well tolerated, and had excellent adherence (≈95% of training sessions completed). Casual systolic blood pressure decreased from 135±2 mm Hg to 126±3 mm Hg ( P <0.01) with IMST, which was ≈75% sustained 6 weeks after IMST ( P <0.01), whereas IMST modestly decreased casual diastolic blood pressure (79±2 mm Hg to 77±2 mm Hg, P =0.03); blood pressure was unaffected by sham training (all P >0.05). Twenty‐four hour systolic blood pressure was lower after IMST versus sham training ( P =0.01). Brachial artery flow‐mediated dilation improved ≈45% with IMST ( P <0.01) but was unchanged with sham training ( P =0.73). Human umbilical vein endothelial cells cultured with subject serum sampled after versus before IMST exhibited increased NO bioavailability, greater endothelial NO synthase activation, and lower reactive oxygen species bioactivity ( P <0.05). IMST decreased C‐reactive protein ( P =0.05) and altered select circulating metabolites (targeted plasma metabolomics) associated with cardiovascular function. Neither IMST nor sham training influenced arterial stiffness ( P >0.05). Conclusions High‐resistance IMST is a safe, highly adherable lifestyle intervention for improving blood pressure and endothelial function in midlife/older adults with above‐normal initial systolic blood pressure. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03266510.

The aortic-femoral arterial stiffness gradient is blood pressure independent in older adults

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Keeron Stone ◽  
Simon Fryer ◽  
James Faulkner ◽  
Michelle L. Meyer ◽  
Kevin Heffernan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Arterial Stiffness ◽  
Pressure Independent

scholarly journals DOES GENDER INFLUENCE RISK FOR ORTHOSTATIC HYPOTENSION IN OLDER ADULTS WITH SARCOPENIA?

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S682-S682
Author(s):  
Melissa J Benton ◽  
Amy L Silva-Smith ◽  
Jefferson M Spicher
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Systolic Blood Pressure ◽  
Orthostatic Hypotension ◽  
Lean Mass ◽  
Bioelectrical Impedance ◽  
Early Morning ◽  
Postural Changes ◽  
Before And After ◽  
Pressure Changes

Abstract Older adults with sarcopenia may be at risk for unstable postural blood pressure due to diminished lean mass that plays a role in maintaining fluid volume. Males have greater lean mass, so risk may be mediated by gender. We compared postural blood pressure changes in older men (77.1 ± 2.0 years; n = 15) and women (79.6 ± 2.0 years; n = 13) with sarcopenia before and after an overnight fast. Sarcopenia was defined using the Lean Mass Index (males ≤ 19.0 kg/m2; females ≤ 15.0 kg/m2). Body composition was measured using multi-frequency bioelectrical impedance, and blood pressure was measured lying, sitting, and standing. On Day 1 (normally hydrated) there were significant drops in systolic blood pressure, with an overall decrease of -9.1 ± 2.2 mmHg (p &lt; 0.001) between lying and standing. On Day 2 (overnight fast), postural changes were more profound, with an overall decrease of -14.1 ± 2.8 mmHg (p &lt; 0.001). However, when compared by gender, postural changes between lying and standing remained significant but did not differ between men and women (Day 1: men -8.9 ± 2.5 vs. women -9.3 ± 2.5 mmHg; Day 2: men -14.6 ± 4.6 vs. women -13.6 ± 3.1 mmHg). On both days diastolic blood pressure remained stable. In this group of older adults, significant decreases in postural systolic blood pressure were observed in the early morning fasted condition, increasing the risk for orthostatic hypotension (drop in systolic blood pressure -20.0 mmHg). Interestingly, gender did not influence risk.

Abstract 13: Mineralocorticoid Receptor Blockade does not Result in Arterial Destiffening in Healthy Older Adults

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Demetra D Christou ◽  
Jeung-Ki Yoo ◽  
Moon-Hyon Hwang ◽  
Meredith Luttrell ◽  
Han-Kyul Kim ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Carotid Artery ◽  
Arterial Stiffness ◽  
Mineralocorticoid Receptor ◽  
Augmentation Index ◽  
Stiffness Index ◽  
Double Blind ◽  
Healthy Older Adults ◽  
Carotid Artery Compliance

Arterial stiffness, an independent predictor of cardiovascular disease, is increased in aging, but the underlying mechanisms are not completely understood. We hypothesized that mineralocorticoid receptor (MR) activation is partly responsible for increased arterial stiffness and that MR blockade would lead to arterial destiffening in healthy older adults. To test this hypothesis, we administered in a randomized, double blind, crossover study, 100 mg of Eplerenone (MR blocker) or placebo once per day for one month with one month washout, in 23 healthy older adults (age, 64±1 years; mean±SE) and assessed arterial stiffness (aortic, arm and leg pulse wave velocity (PWV; doppler flowmeter) and carotid artery compliance, distensibility, beta-stiffness index, augmentation index (high resolution ultrasonography and applanation tonometry). Despite reductions in blood pressure in response to Eplerenone (systolic blood pressure: 127±3 vs. 120±2 mmHg, P=0.01; diastolic blood pressure: 74±1 vs.72±1 mmHg, P=0.02; placebo vs. Eplerenone), arterial stiffness did not change (aortic PWV, 9.2±1.2 vs. 8.9±1.2m/sec, P=0.5; arm PWV, 11.4±0.6 vs. 11.7±0.7 m/sec, P=0.7; leg PWV, 13.4±0.4 vs.12.8±0.5 m/sec, P=0.3; carotid artery compliance, 0.17±0.02 vs. 0.16±0.02 mm 2 /mmHg, P=0.6; distensibility, 12.7±1.6 vs.13.6±1.5 10 -3 kPa -1 , P=0.6; beta stiffness index, 3.2±0.3 vs. 3.4±0.3, P=0.5; augmentation index, 24.3±2.9 vs. 22.0±2.9 %, P=0.3, placebo vs. Eplerenone). In conclusion, MR blockade does not result in arterial destiffening in healthy older adults despite reductions in blood pressure.

Blood Pressure Components and Cardiovascular Events in Older Adults: The Rotterdam Study

2004 ◽  
Vol 52 (9) ◽  
pp. 1538-1542 ◽  
Author(s):  
Francesco U. S. Mattace-Raso ◽  
Tischa J. M. Van Der Cammen ◽  
Nicole M. Van Popele ◽  
Deirdre A. M. Van Der Kuip ◽  
Maarten A. D. H. Schalekamp ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Cardiovascular Events ◽  
Rotterdam Study

P4.15 RELATIONSHIP BETWEEN ARTERIAL STIFFNESS, CARDIAC BAROREFLEX SENSITIVITY AND BLOOD PRESSURE VARIABILITY IN NORMOTENSIVE HEALTHY ADULTS

2012 ◽  
Vol 6 (4) ◽  
pp. 187
Author(s):  
J.E. Ochoa ◽  
M.M. Correa ◽  
A.M. Valencia ◽  
J.G. McEwen ◽  
J.A. Gallo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Blood Pressure Variability ◽  
Baroreflex Sensitivity ◽  
Healthy Adults
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