Tear Organic Acid Analysis After Corneal Collagen Crosslinking in Keratoconus

Purpose. To evaluate the efficacy of corneal collagen crosslinking for progressive keratoconus in paediatric patients.Methods. This prospective study included 25 eyes of 18 patients (aged 18 years or younger) who underwent collagen crosslinking performed using riboflavin and ultraviolet-A irradiation (370 nm, 3 mW/cm2, 30 min).Results. The mean patient age was 14.3 ± 2.4 years (range 8–17) and mean followup duration was 20.1 ± 14.25 months (range 6–48). Crosslinked eyes demonstrated a significant reduction of keratometry values. The mean baseline simulated keratometry values were 46.34 dioptres (D) in the flattest meridian and 50.06 D in the steepest meridian. At 20 months after crosslinking, the values were 45.67 D (P=0.03) and 49.34 D (P=0.005), respectively. The best spectacle corrected visual acuity (BSCVA) and topometric astigmatism improved after crosslinking. Mean logarithm of the minimum angle of resolution (logMAR) BSCVA decreased from 0.24 to 0.21 (P=0.89) and topometric astigmatism reduced from mean 3.50 D to 3.25 D (P=0.51).Conclusions. Collagen crosslinking using riboflavin and ultraviolet-A is an effective treatment option for progressive keratoconus in paediatric patients. Crosslinking stabilises the condition and, thus, reduces the need for corneal grafting in these young patients.

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Intrastromal corneal rings and corneal collagen crosslinking for progressive keratoconus: comparison of two sequences

Eye ◽

10.1038/eye.2014.285 ◽

2014 ◽

Vol 29 (2) ◽

pp. 294-295 ◽

Cited By ~ 4

Author(s):

N Saib ◽

S Bonnel ◽

J-R Fenolland ◽

M Abrieu ◽

C Rambaud ◽

...

Keyword(s):

Collagen Crosslinking ◽

Corneal Collagen Crosslinking ◽

Corneal Collagen

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Evaluation of changes in corneal biomechanics in eyes with keratectasia

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-5-179-187 ◽

2021 ◽

pp. 179-187

Author(s):

B.E. Malugin ◽

◽

E.G. Solodkova ◽

S.V. Balalin ◽

V.S. Kulikov ◽

...

Keyword(s):

Corneal Thickness ◽

Corneal Biomechanics ◽

Corvis St ◽

Collagen Crosslinking ◽

The Third ◽

Corneal Rigidity ◽

Corneal Collagen Crosslinking ◽

Early Features ◽

Healthy Persons ◽

Corneal Collagen

Purpose. To make a comparative analysis of topographic, tomographic and biomechanical values, measured by Pentacam HR and Corvis ST, in healthy multirefractive cohort versus patients with keratectasia of various severity. Material and methods. The prospective study comprised 237 patients aged from 18 to 47 years, subdivided into three groups. The first group included 174 healthy persons with various refraction (174 eyes). The second and the third group embraced 63 patients with keratoconus: 36 patients (36 eyes) with keratoconus of the I degree and 27 eyes with keratoconus of the II and III degrees. Besides the conventional comprehensive ocular examination the following studies were performed in all the patients: evaluation of topographic, tomographic and biomechanical corneal properties with application of Pentacam HR and Corvis ST (OCULUS Optikgerate GmbH; Wetzlar, Germany). Results. It was revealed that the following biomechanical values, assessed by means of Pentacam HR and Corvis ST, exhibited statistically significant changes (p<0,001) in all degrees of ketatoconus: a relative corneal thickness by Ambrosio, inverted radius of applanation curvature (IntRadius), DA Ratio Coefficient, values of corneal rigidity – SP-A 1 and SSI. Conclusion. The detected parameters may be applied as indicators, allowing to evaluate corneal biomechanics, to define early features of ectatic process, to assess effectiveness of the performed corneal collagen crosslinking and intralamellar keratoplasty with implantation of corneal segments. Key words: keratoconus, corneal biomechanics, pachymetry, index of pachymetric progression, corneal viscoelasticity.

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