Donor Site Morbidity Associated With Autogenous Bone Harvesting From the Ascending Mandibular Ramus

Abstract Background Autogenous bone augmentation is the gold standard for the treatment of extended bone defects prior to implantation. Bone augmentation from the zygomatic crest is a valuable option with several advantages, but the current literature for this treatment is scant. The aim of this study was to evaluate the increase in bone volume after locoregional bone augmentation using autogenous bone from the zygomatic alveolar crest as well as the complications and success rate. Results Analysis of the augmented bone volume in seven patients showed a maximum volume gain of 0.97 cm3. An average of 0.54 cm3 of autogenous bone (SD 0.24 cm3; median: 0.54 cm3) was augmented. Implantation following bone augmentation was possible in all cases. Complications occurred in three patients. Conclusion The zygomatic alveolar crest is a valuable donor site for autogenous alveolar onlay grafting in a locoregional area such as the maxillary front. Low donor site morbidity, good access, and its suitable convexity make it a beneficial choice for autogenous bone augmentation.

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Donor-site morbidity after chin bone harvesting

BDJ ◽

10.1038/sj.bdj.4810985 ◽

2004 ◽

Vol 196 (4) ◽

pp. 211-211

Author(s):

P D Robinson

Keyword(s):

Donor Site ◽

Donor Site Morbidity ◽

Bone Harvesting

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Nano-Mechanical Properties of Bioceramic Bone Scaffolds Fabricated at Three Sintering Temperatures

ASME 2011 Summer Bioengineering Conference, Parts A and B ◽

10.1115/sbc2011-53734 ◽

2011 ◽

Author(s):

Juan Vivanco ◽

Josh Slane ◽

Heidi Ploeg

Keyword(s):

Donor Site ◽

Three Dimensional ◽

Ceramic Materials ◽

The United States ◽

Bone Defects ◽

Donor Site Morbidity ◽

Autogenous Bone ◽

Common Procedure ◽

Bioactive Ceramic ◽

Autogenous Bone Grafts

Bone grafting is an exceptionally common procedure used to repair bone defects within orthopaedics, craniofacial surgery and dentistry. It is estimated that 2.2 million grafting procedures are performed annually worldwide [1] and maintain a market share of $7 billion in the United States alone [2]. There has been a considerable rise in the interest of using bioactive ceramic materials, such as hydroxyapatite and tricalcium phosphate (TCP), to serve as synthetic replacements for autogenous bone grafts, which suffer from donor site morbidity and limited supply [3]. These ceramic materials (which can be formed into three-dimensional scaffolds) are advantageous due to their inherent biocompatibility, osteoconductivy, osteogenecity and osteointegrity [2].

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Donor site morbidity following iliac crest bone harvesting for cervical fusion: a comparison between minimally invasive and open techniques

European Spine Journal ◽

10.1007/s00586-008-0648-3 ◽

2008 ◽

Vol 17 (6) ◽

pp. 845-852 ◽

Cited By ~ 72

Author(s):

Raymond Pollock ◽

Ilhan Alcelik ◽

Chandra Bhatia ◽

Graham Chuter ◽

Kiran Lingutla ◽

...

Keyword(s):

Minimally Invasive ◽

Iliac Crest ◽

Donor Site ◽

Donor Site Morbidity ◽

Cervical Fusion ◽

Bone Harvesting

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Donor site morbidity with reamer-irrigator-aspirator (RIA) use for autogenous bone graft harvesting in a single centre 204 case series

Injury ◽

10.1016/j.injury.2013.06.008 ◽

2013 ◽

Vol 44 (10) ◽

pp. 1263-1269 ◽

Cited By ~ 28

Author(s):

Lars M. Qvick ◽

Christopher A. Ritter ◽

Christopher E. Mutty ◽

Bernhard J. Rohrbacher ◽

Cathy M. Buyea ◽

...

Keyword(s):

Bone Graft ◽

Donor Site ◽

Case Series ◽

Donor Site Morbidity ◽

Autogenous Bone Graft ◽

Autogenous Bone ◽

Single Centre ◽

Bone Graft Harvesting

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Donor site morbidity after bone harvesting from the anterior iliac crest

Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology ◽

10.1016/j.tripleo.2009.08.023 ◽

2010 ◽

Vol 109 (1) ◽

pp. 52-58 ◽

Cited By ~ 70

Author(s):

Heidrun Schaaf ◽

Stefan Lendeckel ◽

Hans-Peter Howaldt ◽

Philipp Streckbein

Keyword(s):

Iliac Crest ◽

Donor Site ◽

Donor Site Morbidity ◽

Bone Harvesting

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Clinical Use of Bioactive Glasses for Maxillo-Facial Repair

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.377.73 ◽

2008 ◽

Vol 377 ◽

pp. 73-84 ◽

Cited By ~ 1

Author(s):

Ian Thompson ◽

Larry L. Hench

Keyword(s):

Bioactive Glass ◽

Structural Characteristics ◽

Donor Site ◽

Donor Site Morbidity ◽

Autogenous Bone ◽

In Vitro Tests ◽

Cell Cycles ◽

Facial Surgery

Autogenous bone grafts are considered to be the gold standard in maxillo-facial surgery. However, drawbacks of donor site morbidity and unpredictable rates of resorbtion often limit their use. In vivo tests have shown that 45S5 bioactive glass particles placed in critical size bone defects lead to regeneration of new bone that has the structural characteristics and architecture of mature trabecular bone. In vitro tests using primary osteoblast cultures have shown that the bioactive glass particles release ionic dissolution products that provide genetic stimuli that control osteoblast cell cycles and lead to rapid growth of mineralized bone nodules. These in vitro and in vivo results led to approval of use of bioactive glass particles and monolithic bioactive glass implants for use in maxillo-facial reconstructions after removal of bone cysts and trauma, as described by several case histories.

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The Effect of Parathyroid Hormone Analogues When Added to Mineralized Bone Xenografts

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-19-00016 ◽

2020 ◽

Vol 46 (4) ◽

pp. 372-379

Author(s):

Hany Emam ◽

Daniel Leach ◽

Zongyang Sun ◽

Boon Ching Tee ◽

Berfin Karatas ◽

...

Keyword(s):

Parathyroid Hormone ◽

Bone Regeneration ◽

Computerized Tomography ◽

Bone Mineralization ◽

Donor Site ◽

Random Order ◽

Donor Site Morbidity ◽

Mineral Apposition Rate ◽

Autogenous Bone ◽

Positive Trend

Implants can be a treatment option when there is sufficient quantity and quality of bone to provide support for long-term success. In the reconstruction of defects, autogenous bone remains the gold standard for its osteogenic and compatibility properties. However, the disadvantage of secondary surgery and the associated donor site morbidity prompts researchers to develop the ideal bone substitute for optimum bone reconstruction. Parathyroid hormone (PTH1-34) has provided a new option for improvement in bone regeneration. This study used a pig model to evaluate the effectiveness of parathyroid hormone when added to a xenograft, Bio-Oss, in reconstructing mandible defects. Six domestic pigs were used to create 3 posterior mandibular defects measuring 2 × 1-cm bilaterally with a total of 36 defects to simulate tooth extraction sites in humans. The defects were grafted in random order and divided into 3 groups as follows: control (no graft), Bio-Oss without PTH, and Bio-Oss with PTH. Defects were assessed with cone beam computerized tomography (CBCT), micro computerized tomography (microCT), nanoindentation, and histology. Results showed that adding PTH1-34 significantly enhanced the graft construct. CBCT showed a significant increase in the degree of bone mineralization. Nanoindentation showed increased hardness of regenerated bone and accelerated bone mineralization with PTH. MicroCT analysis revealed a trend toward higher bone regeneration and mineralization. The histological analysis showed a positive trend of the increase in cortical bone thickness and mineral apposition rate. In conclusion, the local addition of PTH1-34 to a xenograft has shown promising results to enhance bone regeneration in the reconstruction of mandibular defects.

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