Clinical Analysis of Primary Primitive Neuroectodermal Tumors in the Female Genital Tract

2014 ◽  
Vol 24 (3) ◽  
pp. 404-409 ◽  
Author(s):  
Changji Xiao ◽  
Jing Zhao ◽  
Peng Guo ◽  
Dan Wang ◽  
Dachun Zhao ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Clinical Manifestations ◽  
Neuron Specific Enolase ◽  
Lower Abdominal Pain ◽  
Primitive Neuroectodermal Tumors ◽  
Pathologic Features ◽  
Neuroectodermal Tumors ◽  
Female Genital

ObjectiveThe aim of the study was to investigate the clinical manifestations, diagnosis, treatment, and prognosis of primitive neuroectodermal tumors (PNETs) in the female genital tract.MethodsFrom April 2001 to May 2013, the clinicopathologic characteristics, treatments, outcomes, and prognosis of 11 patients with PNET in the female genital tract were analyzed retrospectively at our hospital.ResultsThe location of PNET in the 11 patients presented here included vulva (2 patients), cervix (2 patients), uterus and its ligament (5 patients), and the ovaries (2 patients). Ages ranged from 18 to 59 years (median, 31 years).The main clinical manifestations of PNET in the female genital tract are irregular vaginal bleeding (6 patients), pelvic mass, uterine enlargement, and rapidly increasing vulvar mass (8 patients), and vulvar pain and lower abdominal pain (5 patients). The CA125 levels of 8 patients were elevated before the operations and reduced to normal when the diseases were controlled, while the levels increased as the tumor was progressive. Results for the most commonly used immunohistochemistry studies revealed CD99 in 11 of the 11 tumors, synaptophysin in 6 of the 7 positive tumors, and neuron-specific enolase in 6 of the 6 tumors. Ten patients underwent surgical resection. Nine of them underwent preoperative or/and postoperative combination chemotherapy. The follow-up of 10 patients were available and ranged from 1 to 145 months (median, 30.5 months), 3 of whom experiencing recurrence.ConclusionsPrimitive neuroectodermal tumor is very rare and can originate from any part of the female genital tract. The tumors had different manifestations but the same pathologic features. CA125 may be an important marker for prognosis and follow-up of PNET of the female internal genital tract.

scholarly journals Clinical analysis of primitive neuroectodermal tumors in the female genital tract: A report of three cases

2015 ◽  
Vol 54 (6) ◽  
pp. 784-785 ◽  
Author(s):  
Emre Özgü ◽  
Burçin Salman Özgü ◽  
Beril Halisdemir ◽  
İbrahim Kale ◽  
Hatice Bayramoğlu ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Clinical Analysis ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors ◽  
Female Genital

scholarly journals Primitive Neuroectodermal Tumors of the Female Genital Tract

2017 ◽  
Vol 41 (6) ◽  
pp. 761-772 ◽  
Author(s):  
Sarah Chiang ◽  
Matija Snuderl ◽  
Sakiko Kojiro-Sanada ◽  
Ariadna Quer Pi-Sunyer ◽  
Dean Daya ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors ◽  
Female Genital

scholarly journals Cervical Mesonephric Adenocarcinoma: A Case Report of a Rare Gynecological Tumor from Embryological Remains of the Female Genital Tract

2021 ◽  
Author(s):  
Catarina Reis-de-Carvalho ◽  
Carolina Vaz-de-Macedo ◽  
Santiago Ortiz ◽  
Anabela Colaço ◽  
Carlos Calhaz-Jorge
Keyword(s):  
Case Report ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Treatment Protocol ◽  
Gynecology And Obstetrics ◽  
Mesonephric Adenocarcinoma ◽  
Gynecological Tumor ◽  
Cervical Adenocarcinomas ◽  
Female Genital

Abstract Introduction Malignant mesonephric tumors are uncommon in the female genital tract, and they are usually located where embryonic remnants of Wolffian ducts are detected, such as the uterine cervix. The information about these tumors, their treatment protocol, and prognosis are scarce. Case report A 60-year-old woman with postmenopausal vaginal bleeding was initially diagnosed with endometrial carcinoma. After suspicion co-testing, the patient underwent a loop electrosurgical excision of the cervix and was eventually diagnosed with mesonephric adenocarcinoma. She was subjected to a radical hysterectomy, which revealed International Federation of Gynecology and Obstetrics (FIGO) IB1 stage, and adjuvant radiotherapy. The follow-up showed no evidence of recurrence after 60 months. Conclusion We present the case of a woman with cervical mesonephric adenocarcinoma. When compared with the literature, this case had the longest clinical follow-up without evidence of recurrence, which reinforces the concept that these tumors are associated with a favorable prognosis if managed according to the guidelines defined for the treatment of patients with cervical adenocarcinomas. Though a rare entity, it should be kept in mind as a differential diagnosis for other cervical cancers.

Primitive Neuroectodermal Tumor of the Lung

2001 ◽  
Vol 125 (3) ◽  
pp. 397-399
Author(s):  
Andrea G. Kahn ◽  
Alejandra Avagnina ◽  
Jorge Nazar ◽  
Boris Elsner
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
Neuron Specific Enolase ◽  
Middle Lobe ◽  
Neurosecretory Granules ◽  
Primitive Neuroectodermal Tumors ◽  
Ultrastructural Studies ◽  
Neuroectodermal Tumors ◽  
Right Middle Lobe ◽  
Cytoplasmic Processes

Abstract Primitive neuroectodermal tumors occur most frequently in bone and soft tissue but have been reported in other locations. Primary lung primitive neuroectodermal tumors without pleural or chest wall involvement are extremely rare. We present a case with immunohistochemical and ultrastructural studies and follow-up of the patient. An 18-year-old man presented with hemoptysis. Chest radiographs revealed a right middle lobe mass, and bronchoscopy showed an endobronchial tumor. The lesion was resected by middle lobectomy. After 2 years, a local recurrence was treated by pneumonectomy. The patient died after surgery. Histologically, the tumor was composed of uniform cells with round nuclei and scanty cytoplasm arranged in cohesive lobules with occasional rosette formation. Immunohistochemically, the tumor was positive for vimentin, CD99, neuron-specific enolase, and neurofilaments. Ultrastructural study revealed neurosecretory granules and cytoplasmic processes. Our case shows the value of immunohistochemistry and electron microscopy in the diagnosis of primitive neuroectodermal tumors in unusual locations.

scholarly journals Management of Transverse Vaginal Septum by Vaginoscopic Resection: Hymen Conservative Technique

2018 ◽  
Vol 40 (10) ◽  
pp. 642-646
Author(s):  
Gennaro Scutiero ◽  
Pantaleo Greco ◽  
Piergiorgio Iannone ◽  
Giulia Bernardi ◽  
Francesca Greco ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Genital Tract ◽  
Cultural Beliefs ◽  
Foley Catheter ◽  
Female Genital Tract ◽  
Vaginal Septum ◽  
Menstrual Flow ◽  
Transverse Vaginal Septum ◽  
Female Genital

AbstractTransverse vaginal septum is a rare female genital tract anomaly, and little is described about its surgical treatment. We report the case of a patient who wished to preserve hymenal integrity due to social and cultural beliefs. We performed a vaginoscopic resection of the septum under laparoscopic view, followed by the introduction of a Foley catheter in the vagina, thus preserving the hymen. After 12 months of follow-up, no septal closure was present, and the menstrual flow was effective. Vaginoscopic hysteroscopy is an effective method of vaginal septum resection, even in cases in which hymenal integrity must be preserved due to social and cultural beliefs.

Late toxicity of brachytherapy after female genital tract tumors treated during childhood: Prospective evaluation with a long-term follow-up

2015 ◽  
Vol 117 (2) ◽  
pp. 206-212 ◽  
Author(s):  
Antonin Levy ◽  
Helene Martelli ◽  
Chiraz Fayech ◽  
Veronique Minard-Colin ◽  
Isabelle Dumas ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Late Toxicity ◽  
Prospective Evaluation ◽  
Long Term Follow Up ◽  
Female Genital

scholarly journals Malignant Tumors of the Female Genital Tract – a Hospital Based Analysis

2016 ◽  
Vol 10 (2) ◽  
pp. 24-28
Author(s):  
R Joshi ◽  
G Baral ◽  
K Malla
Keyword(s):  
Ovarian Cancer ◽  
Cervical Cancer ◽  
Endometrial Cancer ◽  
Genital Tract ◽  
Malignant Tumors ◽  
Female Genital Tract ◽  
Limited Data ◽  
Corpus Uteri ◽  
Female Genital

Aims: The incidence of cancer and the cancer related deaths are increasing worldwide. There is limited data regarding  gynecological cancers in Nepal. This study is conducted to analyze the trends of female genital tract malignancies in Paropakar Maternity and Women’s Hospital (PMWH) and compare it with the national/international data.Methods: This was a retrospective study conducted in Department of Obstetrics/Gynecology and Pathology in PMWH.  All female diagnosed with the genital tract malignancies from July 2013 to July 2015 were included in the study.Results: Among 62 cases, cervical cancer was the commonest (71%) followed by ovarian cancer (14%), endometrial cancer (8%) and choriocarcinoma (3%). Majority of women belonged to 50-59 years for each type of tumors. Four-fifth of endometrial, half of the cervical and one-third of ovarian cancers were among grand-multipara. Sixty nine percent of women received treatment with 22 (9 cervical, 9 ovarian, 3 endometrial and one of corpus uteri)  surgical and 21 primary chemo/radiotherapy but 19 (31%) were lost for follow-up. Squamous type of cervical cancer was the commonest (93%).Conclusions: Cervical cancer was the commonest genital tract malignancy followed by ovarian cancer, endometrial cancer and choriocarcinoma. For each type of tumors, 50-59 years was the common age group and grand multiparity was seen in half of the women with the cervical cancer. Squamous type of cervical cancer was the commonest variety.  

scholarly journals Prevention of reproductive disorders in women with female genital tract malformations

2020 ◽  
Keyword(s):  
Reproductive Health ◽  
Reproductive System ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Clinical Manifestations ◽  
Female Genitalia ◽  
Control Group ◽  
Reproductive Disorders ◽  
Health Disorders ◽  
Female Genital

Summary. Reproductive health is a priority in today’s global health care system. Among the factors of reproductive health disorders are female genital tract malformations. This pathology is mostly diagnosed with the onset of reproductive disorders at different ages of women, negatively affecting not only the reproductive but also the sexual functions of women, absorbing the quality of her life. The objective: to develop measures for the prevention of reproductive disorders in patients with female genital tract malformations based on the assessment of clinical manifestations and the frequency of reproductive disorders. Materials and methods. A retrospective assessment of reproductive disorders in 84 patients with a verified diagnosis of abnormalities in the development of the female genital organs was performed. The diagnosis was based on complaints, anamnestic data, the results of objective examination, clinical, laboratory and instrumental methods. The control group consisted of 25 women without abnormalities in the development of the female genitalia. Results. The mean age of the surveyed women was 27.6 ± 3.8 years. The duration of verification of the diagnosis of female genital tract malformations from the moment of the first visit to the gynecologist took an average of 3.1 ± 1.3 years. Of all the abnormalities in the development of the female reproductive system, 14.3 % were so-called «obstructive» abnormalities associated with impaired menstrual blood flow. Therefore, their clinical manifestation was earlier and more pronounced than in other patients and was manifested primarily by severe dysmenorrhea. Deviations in the age of onset of menarche occurred in 25 % of patients (OR =8; 95 % CI 1,019 – 62,798). In 73.8 % of women, the first reproductive disorders began during puberty. Dys menorrhea of varying severity occurred in 69.1 % of patients (OR = 7,064; 95 % СІ 2,527 – 19,744), of whom 70.6 % used medical treatment. The share of infertility among the women with anomalies in the development of the reproductive system was 19.1 %, pregnancy loss – 40.5 %. It was found that the risk of miscarriage in patients with congenital pathology of the female genitalia increases significantly (OR = 3,570; 95 % CI 1,125 – 11,325). 34.5 % of patients were diagnosed with genital endometriosis (OR = 6,064; 95 % СI 1,335 – 27,540). In 21.4 % of cases, abnormalities in the development of the female genitals were combined with congenital kidney disease. Conclusions. Prevention and predictability of reproductive disorders in patients with female genital tract malformations should begin with the pubertal period of the girl. A separate risk group consists of girls with pathology of the kidneys diagnosed prenatally. The basis for the prevention of reproductive health disorders in women with female genital tract malformations is the timely verification of congenital pathology and the development of a personalized system of management. The results of our research and the literature suggest that verification of the diagnosis of female genital tract malformations in women usually begins when patients have lost pregnancy or are experiencing infertility, while dysmenorrhea, menstrual irregularities that may occur in adolescence, often do not alert and do not become the basis for exclusion of congenital anomalies. That is why we believe that screening ultrasound examination of the pelvic organs in the presence of these disorders, it is advisable to conduct girls during puberty, if necessary – using 3D ultrasound and/or MRI.

Effective multimodality treatment for advanced epidermoid carcinoma of the female genital tract.

1985 ◽  
Vol 3 (7) ◽  
pp. 917-924 ◽  
Author(s):  
J Kalra ◽  
E Cortes ◽  
S Chen ◽  
B Krumholz ◽  
J J Rovinsky ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Multimodality Treatment ◽  
Tumor Shrinkage ◽  
Simultaneous Administration ◽  
Recurrent Squamous Cell Carcinoma ◽  
Complete Tumor ◽  
Female Genital

Fifteen patients with advanced or recurrent squamous-cell carcinoma of the cervix, vulva, vagina, and urethra were treated with simultaneous combination chemotherapy (5-fluorouracil infusion and mitomycin C) and radiotherapy (3,000 rad for a period of three weeks). Three to four weeks after completion of radiotherapy, 13 of 15 patients achieved partial or complete tumor shrinkage. Nine of 15 patients are alive, eight of whom (at a median follow-up time of 24 months) have no evidence of disease. The longest survival time was 45 + months. There was minimal toxicity associated with this therapy. The results of this pilot study suggest that the simultaneous administration of radiation and chemotherapy is an effective method of treatment of advanced female genital tract carcinoma.

scholarly journals Tubo-Ovarian Abscess Occurring 16 Years After Supracervical Hysterectomy

2003 ◽  
Vol 11 (3) ◽  
pp. 167-169 ◽  
Author(s):  
Toshimitsu Tohya ◽  
Toshihiro Yoshimura ◽  
Chikashi Onoda
Keyword(s):  
Genital Tract ◽  
Transvaginal Ultrasound ◽  
Female Genital Tract ◽  
Lower Abdominal Pain ◽  
Pathologic Examination ◽  
Supracervical Hysterectomy ◽  
Tender Mass ◽  
The Right ◽  
Ovarian Abscess ◽  
Female Genital

Background:Supracervical hysterectomy is seldom performed and there are few reports of tubo-ovarian abscess (TOA) after supracervical hysterectomy.Case:The case of a 49-year-old woman with a right TOA is reported. This patient had received a supracervical hysterectomy 16 years earlier due to rupture of the uterus. At this admission, she presented with complaints of lower abdominal pain and fever. Bimanual and transvaginal ultrasound examinations demonstrated a tender mass in the right adnexal region. Laparotomy, pathologic examination and microbiologic study confirmed the diagnosis of right TOA.Conclusion:After supracervical hysterectomy, patients may develop endocervicitis, parametritis and/or TOA. This series may be a subtype of ascending infections in the female genital tract.

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