Effective multimodality treatment for advanced epidermoid carcinoma of the female genital tract.

1985 ◽  
Vol 3 (7) ◽  
pp. 917-924 ◽  
Author(s):  
J Kalra ◽  
E Cortes ◽  
S Chen ◽  
B Krumholz ◽  
J J Rovinsky ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Multimodality Treatment ◽  
Tumor Shrinkage ◽  
Simultaneous Administration ◽  
Recurrent Squamous Cell Carcinoma ◽  
Complete Tumor ◽  
Female Genital

Fifteen patients with advanced or recurrent squamous-cell carcinoma of the cervix, vulva, vagina, and urethra were treated with simultaneous combination chemotherapy (5-fluorouracil infusion and mitomycin C) and radiotherapy (3,000 rad for a period of three weeks). Three to four weeks after completion of radiotherapy, 13 of 15 patients achieved partial or complete tumor shrinkage. Nine of 15 patients are alive, eight of whom (at a median follow-up time of 24 months) have no evidence of disease. The longest survival time was 45 + months. There was minimal toxicity associated with this therapy. The results of this pilot study suggest that the simultaneous administration of radiation and chemotherapy is an effective method of treatment of advanced female genital tract carcinoma.

scholarly journals Cervical Mesonephric Adenocarcinoma: A Case Report of a Rare Gynecological Tumor from Embryological Remains of the Female Genital Tract

2021 ◽  
Author(s):  
Catarina Reis-de-Carvalho ◽  
Carolina Vaz-de-Macedo ◽  
Santiago Ortiz ◽  
Anabela Colaço ◽  
Carlos Calhaz-Jorge
Keyword(s):  
Case Report ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Treatment Protocol ◽  
Gynecology And Obstetrics ◽  
Mesonephric Adenocarcinoma ◽  
Gynecological Tumor ◽  
Cervical Adenocarcinomas ◽  
Female Genital

Abstract Introduction Malignant mesonephric tumors are uncommon in the female genital tract, and they are usually located where embryonic remnants of Wolffian ducts are detected, such as the uterine cervix. The information about these tumors, their treatment protocol, and prognosis are scarce. Case report A 60-year-old woman with postmenopausal vaginal bleeding was initially diagnosed with endometrial carcinoma. After suspicion co-testing, the patient underwent a loop electrosurgical excision of the cervix and was eventually diagnosed with mesonephric adenocarcinoma. She was subjected to a radical hysterectomy, which revealed International Federation of Gynecology and Obstetrics (FIGO) IB1 stage, and adjuvant radiotherapy. The follow-up showed no evidence of recurrence after 60 months. Conclusion We present the case of a woman with cervical mesonephric adenocarcinoma. When compared with the literature, this case had the longest clinical follow-up without evidence of recurrence, which reinforces the concept that these tumors are associated with a favorable prognosis if managed according to the guidelines defined for the treatment of patients with cervical adenocarcinomas. Though a rare entity, it should be kept in mind as a differential diagnosis for other cervical cancers.

scholarly journals Management of Transverse Vaginal Septum by Vaginoscopic Resection: Hymen Conservative Technique

2018 ◽  
Vol 40 (10) ◽  
pp. 642-646
Author(s):  
Gennaro Scutiero ◽  
Pantaleo Greco ◽  
Piergiorgio Iannone ◽  
Giulia Bernardi ◽  
Francesca Greco ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Genital Tract ◽  
Cultural Beliefs ◽  
Foley Catheter ◽  
Female Genital Tract ◽  
Vaginal Septum ◽  
Menstrual Flow ◽  
Transverse Vaginal Septum ◽  
Female Genital

AbstractTransverse vaginal septum is a rare female genital tract anomaly, and little is described about its surgical treatment. We report the case of a patient who wished to preserve hymenal integrity due to social and cultural beliefs. We performed a vaginoscopic resection of the septum under laparoscopic view, followed by the introduction of a Foley catheter in the vagina, thus preserving the hymen. After 12 months of follow-up, no septal closure was present, and the menstrual flow was effective. Vaginoscopic hysteroscopy is an effective method of vaginal septum resection, even in cases in which hymenal integrity must be preserved due to social and cultural beliefs.

Late toxicity of brachytherapy after female genital tract tumors treated during childhood: Prospective evaluation with a long-term follow-up

2015 ◽  
Vol 117 (2) ◽  
pp. 206-212 ◽  
Author(s):  
Antonin Levy ◽  
Helene Martelli ◽  
Chiraz Fayech ◽  
Veronique Minard-Colin ◽  
Isabelle Dumas ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Late Toxicity ◽  
Prospective Evaluation ◽  
Long Term Follow Up ◽  
Female Genital

scholarly journals Synchronous endometrioid carcinoma of the endometrium and small cell neuroendocrine carcinoma of the cervix: a rare combination

2018 ◽  
pp. bcr-2018-227155
Author(s):  
Tripti Nakra ◽  
Rituparna Biswas ◽  
Rambha Pandey ◽  
Rajni Yadav
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Multimodality Treatment ◽  
Small Cell ◽  
Endometrioid Carcinoma ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Multiple Primaries ◽  
Tumour Bulk ◽  
Female Genital

Synchronous multiple primaries of female genital tract are uncommon, with the most frequently encountered combination being of endometrium and ovary. Concurrent primary tumours of endometrium and cervix are rare. We report a case of coexistent endometrioid carcinoma of the endometrium and small cell neuroendocrine carcinoma of the cervix in 48-year-old woman who presented with menometrorrhagia and was detected to have metastases to distant sites on imaging. She underwent multimodality treatment which resulted in a significant reduction in the tumour bulk.

scholarly journals Malignant Tumors of the Female Genital Tract – a Hospital Based Analysis

2016 ◽  
Vol 10 (2) ◽  
pp. 24-28
Author(s):  
R Joshi ◽  
G Baral ◽  
K Malla
Keyword(s):  
Ovarian Cancer ◽  
Cervical Cancer ◽  
Endometrial Cancer ◽  
Genital Tract ◽  
Malignant Tumors ◽  
Female Genital Tract ◽  
Limited Data ◽  
Corpus Uteri ◽  
Female Genital

Aims: The incidence of cancer and the cancer related deaths are increasing worldwide. There is limited data regarding  gynecological cancers in Nepal. This study is conducted to analyze the trends of female genital tract malignancies in Paropakar Maternity and Women’s Hospital (PMWH) and compare it with the national/international data.Methods: This was a retrospective study conducted in Department of Obstetrics/Gynecology and Pathology in PMWH.  All female diagnosed with the genital tract malignancies from July 2013 to July 2015 were included in the study.Results: Among 62 cases, cervical cancer was the commonest (71%) followed by ovarian cancer (14%), endometrial cancer (8%) and choriocarcinoma (3%). Majority of women belonged to 50-59 years for each type of tumors. Four-fifth of endometrial, half of the cervical and one-third of ovarian cancers were among grand-multipara. Sixty nine percent of women received treatment with 22 (9 cervical, 9 ovarian, 3 endometrial and one of corpus uteri)  surgical and 21 primary chemo/radiotherapy but 19 (31%) were lost for follow-up. Squamous type of cervical cancer was the commonest (93%).Conclusions: Cervical cancer was the commonest genital tract malignancy followed by ovarian cancer, endometrial cancer and choriocarcinoma. For each type of tumors, 50-59 years was the common age group and grand multiparity was seen in half of the women with the cervical cancer. Squamous type of cervical cancer was the commonest variety.  

Clinical Analysis of Primary Primitive Neuroectodermal Tumors in the Female Genital Tract

2014 ◽  
Vol 24 (3) ◽  
pp. 404-409 ◽  
Author(s):  
Changji Xiao ◽  
Jing Zhao ◽  
Peng Guo ◽  
Dan Wang ◽  
Dachun Zhao ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Clinical Manifestations ◽  
Neuron Specific Enolase ◽  
Lower Abdominal Pain ◽  
Primitive Neuroectodermal Tumors ◽  
Pathologic Features ◽  
Neuroectodermal Tumors ◽  
Female Genital

ObjectiveThe aim of the study was to investigate the clinical manifestations, diagnosis, treatment, and prognosis of primitive neuroectodermal tumors (PNETs) in the female genital tract.MethodsFrom April 2001 to May 2013, the clinicopathologic characteristics, treatments, outcomes, and prognosis of 11 patients with PNET in the female genital tract were analyzed retrospectively at our hospital.ResultsThe location of PNET in the 11 patients presented here included vulva (2 patients), cervix (2 patients), uterus and its ligament (5 patients), and the ovaries (2 patients). Ages ranged from 18 to 59 years (median, 31 years).The main clinical manifestations of PNET in the female genital tract are irregular vaginal bleeding (6 patients), pelvic mass, uterine enlargement, and rapidly increasing vulvar mass (8 patients), and vulvar pain and lower abdominal pain (5 patients). The CA125 levels of 8 patients were elevated before the operations and reduced to normal when the diseases were controlled, while the levels increased as the tumor was progressive. Results for the most commonly used immunohistochemistry studies revealed CD99 in 11 of the 11 tumors, synaptophysin in 6 of the 7 positive tumors, and neuron-specific enolase in 6 of the 6 tumors. Ten patients underwent surgical resection. Nine of them underwent preoperative or/and postoperative combination chemotherapy. The follow-up of 10 patients were available and ranged from 1 to 145 months (median, 30.5 months), 3 of whom experiencing recurrence.ConclusionsPrimitive neuroectodermal tumor is very rare and can originate from any part of the female genital tract. The tumors had different manifestations but the same pathologic features. CA125 may be an important marker for prognosis and follow-up of PNET of the female internal genital tract.

Tumor-Associated Antigens in Female Genital Tract Cancers

1984 ◽  
Vol 70 (3) ◽  
pp. 281-289
Author(s):  
Antonina Harlozinska ◽  
Józef Kula ◽  
Barbara Stepinska ◽  
Michal Jelen ◽  
Roman Richter
Keyword(s):  
Squamous Cell Carcinoma ◽  
Perchloric Acid ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Cervical Squamous Cell Carcinoma ◽  
Cervical Carcinomas ◽  
Uterine Cancers ◽  
Antigenic Heterogeneity ◽  
Uterine Body ◽  
Female Genital

The immunologic reactivity of glycoprotein antigens extractable from individual, histologically different ovarian and uterine cancers was studied taking into account their relationship with carcinoembryonic antigen (CEA), nonspecific cross-reacting antigen (NCA), α-fetoprotein (AFP), and α-1-antichymotrypsin. All studies were performed using specific immune sera against perchloric acid (PCA) extracts of ovarian mucinous cystadenocarcinoma (anti-PCA-CaOm) and cervical squamous cell carcinoma (anti-PCA-CaCx), and antisera against the reference antigens mentioned above. A considerable antigenic heterogeneity and the existence of several immunologically related antigenic systems were found: 1) CEA-like antigens; 2) NCA-type antigens; 3) an antigen different from CEA and NCA present in ovarian mucinous adenocarcinomas and often cross-reacting, but not identical with respective antigens of uterine body and cervical carcinomas; 4) an antigen reacting with anti-α-1-antichymotrypsin serum; and 5) an antigen reacting with anti-AFP serum.

scholarly journals MALIGNANT MELANOMA OF UTERINE CERVIX IN A YOUNG FEMALE

2019 ◽  
pp. 1-2
Author(s):  
Purvi Rathod
Keyword(s):  
Malignant Melanoma ◽  
Uterine Cervix ◽  
Genital Tract ◽  
External Beam Radiotherapy ◽  
Female Genital Tract ◽  
Young Female ◽  
Rare Cancer ◽  
Female Genital

Malignant melanoma is a rare cancer, its incidence being 1% of all cancers. Malignant melanoma of the female genital tract is even rarer with incidence of 3% to 7% of all malignant melanomas. It usually occurs in postmenopausal women. We present a case of malignant melanoma of the uterine cervix in a multiparous premenopausal 29 year old female. She underwent a modified radical hysterectomy. She was stage III and was treated with external beam radiotherapy to the pelvis followed by brachytherapy. Since then the patient was on regular follow up until she developed lung metastasis. Malignant melanoma of the cervix has very less data in literature. Through this case report we will emphasize on the role of radiotherapy in malignant melanoma of uterine cervix

Sign in / Sign up

Export Citation Format

Share Document