scholarly journals Pretreatment Mean Apparent Diffusion Coefficient Is Significantly Correlated With Event-Free Survival in Patients With International Federation of Gynecology and Obstetrics Stage Ib to IIIb Cervical Cancer

2015 ◽  
Vol 25 (6) ◽  
pp. 1079-1085 ◽  
Author(s):  
Yuki Himoto ◽  
Koji Fujimoto ◽  
Aki Kido ◽  
Tsukasa Baba ◽  
Shiro Tanaka ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cervical Cancer ◽  
Diffusion Coefficient ◽  
International Federation ◽  
Resonance Imaging ◽  
Event Free Survival ◽  
Free Survival ◽  
Stage Ib ◽  
Gynecology And Obstetrics ◽  
Apparent Diffusion

ObjectivesTo assess the prognostic impact of the pretreatment mean apparent diffusion coefficient (ADCmean) values of tumors obtained by diffusion-weighted magnetic resonance imaging. We evaluated the prognostic value of the ADCmean for event-free survival (EFS) and overall survival (OS) among patients with uterine cervical cancer.Methods/MaterialsWe included 171 patients diagnosed as having International Federation of Gynecology and Obstetrics stage Ib to IIIb cervical cancer by pretreatment magnetic resonance imaging scans, regardless of therapeutic methods. In all patients and in patients with squamous cell carcinoma (SCC; n = 123), the optimal cutoff values of the tumor ADCmean for EFS and for OS were determined, respectively. The prognostic significance of the ADCmean was evaluated using univariate and multivariate Cox regression analyses.ResultsIn the univariate analyses, the ADCmean values were significantly associated with negative effects on EFS both in all patients and in patients with SCC, while not being significantly associated with OS in both groups. In the multivariate analysis, ADCmean was an independent biomarker for EFS (P < 0.05) in patients with SCC along with lymph node metastasis and definitive surgery, whereas ADCmean was not independently significant in EFS in all patients.ConclusionsThe pretreatment ADCmean value of the tumor was an independent prognostic factor for EFS in International Federation of Gynecology and Obstetrics stage Ib to III SCC of the uterine cervix.

scholarly journals The Value of Diffusion-Weighted Magnetic Resonance Imaging in Predicting the Efficacy of Radiation and Chemotherapy in Cervical Cancer

2018 ◽  
Vol 13 (1) ◽  
pp. 305-311 ◽  
Author(s):  
Jingjing Chen ◽  
Hui Hua ◽  
Jing Pang ◽  
Xianglong Shi ◽  
Weiqun Bi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cervical Cancer ◽  
Diffusion Coefficient ◽  
Magnetic Resonance ◽  
Tumor Diameter ◽  
Resonance Imaging ◽  
Adc Value ◽  
Apparent Diffusion ◽  
Maximum Tumor Diameter ◽  
Weighted Magnetic Resonance Imaging

AbstractBackgroundTo analyze the application value of apparent diffusion coefficient (ADC) and exponent apparent diffusion coefficient (EADC) in evaluating the efficacy of radiation and chemotherapy in cervical cancer using pre- and posttreatment diffusion-weighted magnetic resonance imaging (DW-MRI) scans.Methods52 patients with cervical cancer were administered radiation and chemotherapy. Both MRI and DW-MRI were obtained at different stages. The ADC and EADC values, as well as the maximum tumor diameter, were measured and analyzed.ResultsWe found that the ADC value increased after treatment, and the EADC value decreased. Changes in the calculated ADC occurred earlier than the morphologic changes of the tumors. A negative correlation was detected between reduced rates in the maximum tumor diameter two months after treatment and pretreatment ADC value (r = –0.658, P < 0.05). An ROC curve and nonlinear regression analysis showed that the formula, y = (1525500.122x2 – 4689.962x + 3.482) × 100%, can be used to calculate the percentage of complete remission after treatment according to the pretreatment ADC value.ConclusionOur data suggest that pretreatment ADC and EADC values are predictive of the efficacy of radiation and chemotherapy. Both ADC and EADC values during treatment were instrumental in early monitoring and dynamic observation.

scholarly journals Diffusion-weighted magnetic resonance imaging: biomarker for treatment response in oncology

2013 ◽  
Vol 46 (3) ◽  
pp. 178-180 ◽  
Author(s):  
Maria Luiza Testa ◽  
Rubens Chojniak ◽  
Letícia Silva Sene ◽  
Aline Santos Damascena
Keyword(s):  
Magnetic Resonance Imaging ◽  
Diffusion Coefficient ◽  
Quantitative Assessment ◽  
Therapeutic Response ◽  
Imaging Biomarker ◽  
Resonance Imaging ◽  
Adc Value ◽  
Early Increase ◽  
Apparent Diffusion ◽  
Weighted Magnetic Resonance Imaging

The authors report a case where a quantitative assessment of the apparent diffusion coefficient (ADC) of liver metastasis in a patient undergoing chemotherapy has shown to be an effective early marker for predicting therapeutic response, anticipating changes in tumor size. A lesion with lower initial ADC value and early increase in such value in the course of the treatment tends to present a better therapeutic response.

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