scholarly journals Diffusion-weighted magnetic resonance imaging: biomarker for treatment response in oncology

2013 ◽  
Vol 46 (3) ◽  
pp. 178-180 ◽  
Author(s):  
Maria Luiza Testa ◽  
Rubens Chojniak ◽  
Letícia Silva Sene ◽  
Aline Santos Damascena
Keyword(s):  
Magnetic Resonance Imaging ◽  
Diffusion Coefficient ◽  
Quantitative Assessment ◽  
Therapeutic Response ◽  
Imaging Biomarker ◽  
Resonance Imaging ◽  
Adc Value ◽  
Early Increase ◽  
Apparent Diffusion ◽  
Weighted Magnetic Resonance Imaging

The authors report a case where a quantitative assessment of the apparent diffusion coefficient (ADC) of liver metastasis in a patient undergoing chemotherapy has shown to be an effective early marker for predicting therapeutic response, anticipating changes in tumor size. A lesion with lower initial ADC value and early increase in such value in the course of the treatment tends to present a better therapeutic response.

scholarly journals The Value of Diffusion-Weighted Magnetic Resonance Imaging in Predicting the Efficacy of Radiation and Chemotherapy in Cervical Cancer

2018 ◽  
Vol 13 (1) ◽  
pp. 305-311 ◽  
Author(s):  
Jingjing Chen ◽  
Hui Hua ◽  
Jing Pang ◽  
Xianglong Shi ◽  
Weiqun Bi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cervical Cancer ◽  
Diffusion Coefficient ◽  
Magnetic Resonance ◽  
Tumor Diameter ◽  
Resonance Imaging ◽  
Adc Value ◽  
Apparent Diffusion ◽  
Maximum Tumor Diameter ◽  
Weighted Magnetic Resonance Imaging

AbstractBackgroundTo analyze the application value of apparent diffusion coefficient (ADC) and exponent apparent diffusion coefficient (EADC) in evaluating the efficacy of radiation and chemotherapy in cervical cancer using pre- and posttreatment diffusion-weighted magnetic resonance imaging (DW-MRI) scans.Methods52 patients with cervical cancer were administered radiation and chemotherapy. Both MRI and DW-MRI were obtained at different stages. The ADC and EADC values, as well as the maximum tumor diameter, were measured and analyzed.ResultsWe found that the ADC value increased after treatment, and the EADC value decreased. Changes in the calculated ADC occurred earlier than the morphologic changes of the tumors. A negative correlation was detected between reduced rates in the maximum tumor diameter two months after treatment and pretreatment ADC value (r = –0.658, P < 0.05). An ROC curve and nonlinear regression analysis showed that the formula, y = (1525500.122x2 – 4689.962x + 3.482) × 100%, can be used to calculate the percentage of complete remission after treatment according to the pretreatment ADC value.ConclusionOur data suggest that pretreatment ADC and EADC values are predictive of the efficacy of radiation and chemotherapy. Both ADC and EADC values during treatment were instrumental in early monitoring and dynamic observation.

scholarly journals The Application of Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging in the Diagnosis and Therapy of Acute Cerebral Infarction

2006 ◽  
Vol 2006 ◽  
pp. 1-11 ◽  
Author(s):  
Ying Han ◽  
Enzhong Li ◽  
Jie Tian ◽  
Jian Chen ◽  
Huifang Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Diffusion Coefficient ◽  
Magnetic Resonance ◽  
Cerebral Blood Volume ◽  
Mean Transit Time ◽  
Resonance Imaging ◽  
Stroke Patients ◽  
Apparent Diffusion ◽  
Weighted Magnetic Resonance Imaging ◽  
Adc Map

Diffusion- and perfusion-weighted magnetic resonance imaging (DWI and PWI) was applied for stroke diagnose in 120 acute (<48h) ischemic stroke patients. At hyperacute (<6h) stage, it is difficult to find out the infarction zone in conventional T1 or T2 image, but it is easy in DWI, apparent diffusion coefficient (ADC) map; when at 3–6-hour stage it is also easy in PWI, cerebral blood flow (CBF) map, cerebral blood volume (CBV) map, and mean transit time (MTT) map; at acute (6–48 h) stage, DWI or PWI is more sensitive than conventional T1 or T2 image too. Combining DWI with ADC, acute and chronic infarction can be distinguished. Besides, penumbra which should be developed in meaning was used as an indication or to evaluate the therapeutic efficacy. There were two cases (<1.5h) that broke the model of penumbra because abnormity was found in DWI but not that in PWI, finally they recovered without any sequela.

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