Movement Impairments in Women With and Without Urinary Urgency/Frequency

The last 2 decades have brought an explosion of research, new products, and general attention to the problem of urinary urgency, and yet patients continue to be plagued by this symptom – especially the elderly. What is it? What does it mean? How can we guide patients successfully through this challenge? This paper presents a review of current thinking about urgency relevant to the practicing clinician, including the epidemiology, pathophysiology, evaluation, and treatment of these patients.

Download Full-text

Characterizing the cortical pathways underlying visual trigger induced urinary urgency incontinence by functional MRI

Neurourology and Urodynamics ◽

10.1002/nau.24824 ◽

2021 ◽

Author(s):

Jennifer A. Locke ◽

Andrew Macnab ◽

Saurabh Garg ◽

Martin McKeown ◽

Lynn Stothers

Keyword(s):

Functional Mri ◽

Urinary Urgency ◽

Urgency Incontinence ◽

Urinary Urgency Incontinence

Download Full-text

Urinary urgency, frequency, and urinary incontinence

Algorithms for Obstetrics and Gynaecology ◽

10.1093/med/9780199651399.003.0068 ◽

2014 ◽

pp. 238-241

Author(s):

Sambit Mukhopadhyay ◽

Edward Morris ◽

Sabaratnam Arulkumaran

Keyword(s):

Urinary Incontinence ◽

Urinary Urgency

Download Full-text

Muscarinic Receptor Antagonists, the Overactive Bladder and Efficacy against Urinary Urgency

Clinical Medicine Insights Therapeutics ◽

10.4137/cmt.s4606 ◽

2010 ◽

Vol 2 ◽

pp. CMT.S4606 ◽

Cited By ~ 3

Author(s):

Kylie J. Mansfield

Keyword(s):

Overactive Bladder ◽

Muscarinic Receptor ◽

Cholinergic System ◽

Urge Urinary Incontinence ◽

Urinary Urgency ◽

Receptor Antagonists ◽

Antimuscarinic Agents ◽

Bladder Urothelium ◽

Afferent Nerves ◽

Muscarinic Receptor Antagonists

The overactive bladder (OAB) is a debilitating condition in which patients suffer from urinary urgency, frequency and nocturia with or without urge urinary incontinence. The mainstay of pharmacotherapy for OAB is muscarinic receptor antagonists, which have been shown to be effective treatments for the symptoms of OAB. The mechanism underlying the efficacy of antimuscarinic agents against the symptoms of OAB is not completely understood. This review explores the role of bladder mucosal muscarinic receptors in the signaling pathways that are activated in response to bladder filling. The cholinergic system is seen to be involved in bladder afferent signaling at many levels and as such muscarinic receptor antagonists may affect bladder signaling via numerous pathways including release of mediators from the bladder urothelium and activation of suburothelial myofibroblasts and afferent nerves. Therefore the mucosal cholinergic system may represent another target for the antimuscarinic agents used to treat OAB.

Download Full-text

Ehlers-Danlos syndrome presenting with primary nocturnal enuresis

BMJ Case Reports ◽

10.1136/bcr-2019-231977 ◽

2020 ◽

Vol 13 (2) ◽

pp. e231977

Author(s):

Margarida Cunha ◽

Mafalda Matias ◽

Inês Marques

Keyword(s):

Genetic Testing ◽

Nocturnal Enuresis ◽

Bladder Dysfunction ◽

Connective Tissue Disorder ◽

Joint Hypermobility ◽

Urinary Urgency ◽

Beighton Score ◽

Ehlers Danlos Syndrome ◽

Primary Nocturnal Enuresis ◽

Danlos Syndrome

Ehlers-Danlos syndrome (EDS), hypermobility type, is probably the most common EDS type, as well as the most common heritable connective tissue disorder. Bladder dysfunction is a rare clinical manifestation of EDS and manifests itself as primary nocturnal enuresis. We present a 10-year-old boy referred to the paediatrics nephrology consultation due to primary nocturnal enuresis and day time symptoms of urinary urgency. During the appointment, a tendency to joint hypermobility was noted. On evaluation the skin was hyperextensible and the Beighton score was positive. The genetic testing revealed a variant of the COL5A1 gene not yet described in the literature.

Download Full-text