Contribution of Exocervical Biopsy, Endocervical Curettage, and Colposcopic Grading in Diagnosing High-Grade Cervical Intraepithelial Neoplasia

2016 ◽  
Vol 20 (1) ◽  
pp. 52-56 ◽  
Author(s):  
Justin Thomas Diedrich ◽  
Juan C. Felix ◽  
Neal M. Lonky
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
High Grade

Hybrid Capture II Testing for High-Risk Human Papillomavirus DNA in the Follow-up of Women Treated for High-Grade Cervical Intraepithelial Neoplasia

2013 ◽  
Vol 17 (3) ◽  
pp. 308-314 ◽  
Author(s):  
Jeffrey H.J. Tan ◽  
Suzanne M. Garland ◽  
Sepehr N. Tabrizi ◽  
Elya E. Moore ◽  
Jennifer A. Danielewski ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Hybrid Capture ◽  
Papillomavirus Dna

scholarly journals Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out

2009 ◽  
Vol 127 (5) ◽  
pp. 283-287 ◽  
Author(s):  
Andréa Cytryn ◽  
Fábio Bastos Russomano ◽  
Maria José de Camargo ◽  
Lucília Maria Gama Zardo ◽  
Nilza Maria Sobral Rebelo Horta ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cervical Intraepithelial Neoplasia ◽  
Prevalence Ratio ◽  
Intraepithelial Neoplasia ◽  
Uterine Cervical Cancer ◽  
High Grade ◽  
Cross Sectional ◽  
Squamous Cells ◽  
Bethesda System ◽  
Undetermined Significance

CONTEXT AND OBJECTIVE: The latest update of the Bethesda System divided the category of atypical squamous cells of undetermined significance (ASCUS) into ASC-US (undetermined significance) and ASC-H (high-grade intraepithelial lesion cannot be ruled out). The aims here were to measure the prevalence of pre-invasive lesions (cervical intraepithelial neoplasia, CIN II/III) and cervical cancer among patients referred to Instituto Fernandes Figueira (IFF) with ASC-H cytology, and compare them with ASC-US cases. DESIGN AND SETTING: Cross-sectional study with retrospective data collection, at the IFF Cervical Pathology outpatient clinic. METHODS: ASCUS cases referred to IFF from November 1997 to September 2007 were reviewed according to the 2001 Bethesda System to reach cytological consensus. The resulting ASC-H and ASC-US cases, along with new cases, were analyzed relative to the outcome of interest. The histological diagnosis (or cytocolposcopic follow-up in cases without such diagnosis) was taken as the gold standard. RESULTS: The prevalence of CIN II/III in cases with ASC-H cytology was 19.29% (95% confidence interval, CI, 9.05-29.55%) and the risk of these lesions was greater among patients with ASC-H than with ASC-US cytology (prevalence ratio, PR, 10.42; 95% CI, 2.39-45.47; P = 0.0000764). Pre-invasive lesions were more frequently found in patients under 50 years of age with ASC-H cytology (PR, 2.67; 95% CI, 0.38-18.83); P = 0.2786998). There were no uterine cervical cancer cases. CONCLUSION: The prevalence of CIN II/III in patients with ASC-H cytology was significantly higher than with ASC-US, and division into ASC diagnostic subcategories had good capacity for discriminating the presence of pre-invasive lesions.

Human papilloma virus testing in patient follow-up post cone biopsy due to high-grade cervical intraepithelial neoplasia

2003 ◽  
Vol 88 (3) ◽  
pp. 345-350 ◽  
Author(s):  
Benny Almog ◽  
Ronni Gamzu ◽  
Michael J Kuperminc ◽  
Ishai Levin ◽  
Ofer Fainaru ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Papilloma Virus ◽  
Cone Biopsy ◽  
Virus Testing

Regression of high-grade cervical intraepithelial neoplasia with TG4001 targeted immunotherapy

2011 ◽  
Vol 204 (2) ◽  
pp. 169.e1-169.e8 ◽  
Author(s):  
Jean-Luc Brun ◽  
Véronique Dalstein ◽  
Jean Leveque ◽  
Patrice Mathevet ◽  
Patrick Raulic ◽  
...  
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Targeted Immunotherapy

scholarly journals HPV prevalence and accuracy of HPV testing to detect high-grade cervical intraepithelial neoplasia

2011 ◽  
Vol 130 (6) ◽  
pp. 1387-1394 ◽  
Author(s):  
Paolo Giorgi-Rossi ◽  
Silvia Franceschi ◽  
Guglielmo Ronco
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Hpv Testing ◽  
Hpv Prevalence

scholarly journals Prognostic Significance of Immunohistochemical Phenotypes in Patients Treated for High-Grade Cervical Intraepithelial Neoplasia

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Massimo Origoni ◽  
Marta Parma ◽  
Giacomo Dell'Antonio ◽  
Chiara Gelardi ◽  
Chiara Stefani ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cervical Intraepithelial Neoplasia ◽  
Clinical Outcomes ◽  
Cd4 T Cells ◽  
Prognostic Significance ◽  
Intraepithelial Neoplasia ◽  
Cell Mediated Immunity ◽  
High Grade ◽  
Recurrence Rates

Strong evidence exists that the host’s immune system plays a crucial role for the development of human papillomavirus-related cervical premalignant and malignant lesions. In particular, effective cell-mediated immunity (CMI) promotes spontaneous infection clearance and cancer precursors regression in healthy subjects, while immunosuppressed individuals are more likely to experience infection persistence, cervical intraepithelial neoplasia (CIN) lesions, and cervical cancer. In this study, the prognostic significance of immunohistochemical profiling of CD4+ T-cells, CD8+ T-cells, dendritic cells (CD11c+), T-bet+, and GATA-3+ transcription factors has been studied in surgical specimens of 34 consecutive women affected by high-grade cervical intraepithelial neoplasia (CIN2-3) submitted to cervical conization. Results have been correlated with the clinical outcomes at 24 months after treatment and statistically analyzed. Higher rates of CD4+ T-cells, CD11c+ dendritic cells, and T-bet+ transcription factor positivity showed a strong statistically significative correlation with favourable clinical outcomes (P≤0.0001). These data reinforce the evidence of the relevance of the host’s immune status in the natural history of HPV-related cervical disease and add a prognostic significance of the cervical immunological profile in terms of predicting significant lower recurrence rates.

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