scholarly journals Etiology of acute otitis media and serotype distribution of Streptococcus pneumoniae and Haemophilus influenzae in Chilean children <5 years of age

Medicine ◽  
2017 ◽  
Vol 96 (6) ◽  
pp. e5974 ◽  
Author(s):  
Andres Rosenblut ◽  
Carla Napolitano ◽  
Angelica Pereira ◽  
Camilo Moreno ◽  
Devayani Kolhe ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Acute Otitis Media ◽  
Serotype Distribution

Can acute otitis media caused by Haemophilus influenzae be distinguished from that caused by Streptococcus pneumoniae?

2003 ◽  
Vol 22 (6) ◽  
pp. 509-514 ◽  
Author(s):  
EUGENE LEIBOVITZ ◽  
ROBERT SATRAN ◽  
LOLITA PIGLANSKY ◽  
SIMON RAIZ ◽  
JOSEPH PRESS ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Acute Otitis Media

scholarly journals Bacteriologic Efficacies of Oral Azithromycin and Oral Cefaclor in Treatment of Acute Otitis Media in Infants and Young Children

2000 ◽  
Vol 44 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Ron Dagan ◽  
Eugene Leibovitz ◽  
Dan M. Fliss ◽  
Alberto Leiberman ◽  
Michael R. Jacobs ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Randomized Study ◽  
Acute Otitis Media ◽  
Clear Correlation ◽  
Open Label ◽  
Culture Positive ◽  
Oral Azithromycin ◽  
Infants And Young Children

ABSTRACT A prospective, open-label, randomized study was conducted in order to determine the bacteriologic efficacies of cefaclor and azithromycin in acute otitis media (AOM). Tympanocentesis was performed on entry into the study and 3 to 4 days after initiation of treatment. Bacteriologic failure after 3 to 4 days of treatment with both drugs occurred in a high proportion of culture-positive patients, especially in those in whom AOM was caused by Haemophilus influenzae(16 of 33 [53%] of those treated with azithromycin and 13 of 34 [52%] of those treated with cefaclor). Although a clear correlation of the persistence of the pathogen with increased MICs of the respective drugs could be demonstrated for Streptococcus pneumoniae, no such correlation was found for H. influenzae. It is proposed that susceptibility breakpoints forH. influenzae should be considerably lower than the current ones for both cefaclor and azithromycin for AOM caused by H. influenzae.

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