Can acute otitis media caused by Haemophilus influenzae be distinguished from that caused by Streptococcus pneumoniae?

2003 ◽  
Vol 22 (6) ◽  
pp. 509-514 ◽  
Author(s):  
EUGENE LEIBOVITZ ◽  
ROBERT SATRAN ◽  
LOLITA PIGLANSKY ◽  
SIMON RAIZ ◽  
JOSEPH PRESS ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Acute Otitis Media

scholarly journals Etiology of acute otitis media and serotype distribution of Streptococcus pneumoniae and Haemophilus influenzae in Chilean children <5 years of age

Medicine ◽  
2017 ◽  
Vol 96 (6) ◽  
pp. e5974 ◽  
Author(s):  
Andres Rosenblut ◽  
Carla Napolitano ◽  
Angelica Pereira ◽  
Camilo Moreno ◽  
Devayani Kolhe ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Acute Otitis Media ◽  
Serotype Distribution

scholarly journals Bacteriologic Efficacies of Oral Azithromycin and Oral Cefaclor in Treatment of Acute Otitis Media in Infants and Young Children

2000 ◽  
Vol 44 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Ron Dagan ◽  
Eugene Leibovitz ◽  
Dan M. Fliss ◽  
Alberto Leiberman ◽  
Michael R. Jacobs ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Randomized Study ◽  
Acute Otitis Media ◽  
Clear Correlation ◽  
Open Label ◽  
Culture Positive ◽  
Oral Azithromycin ◽  
Infants And Young Children

ABSTRACT A prospective, open-label, randomized study was conducted in order to determine the bacteriologic efficacies of cefaclor and azithromycin in acute otitis media (AOM). Tympanocentesis was performed on entry into the study and 3 to 4 days after initiation of treatment. Bacteriologic failure after 3 to 4 days of treatment with both drugs occurred in a high proportion of culture-positive patients, especially in those in whom AOM was caused by Haemophilus influenzae(16 of 33 [53%] of those treated with azithromycin and 13 of 34 [52%] of those treated with cefaclor). Although a clear correlation of the persistence of the pathogen with increased MICs of the respective drugs could be demonstrated for Streptococcus pneumoniae, no such correlation was found for H. influenzae. It is proposed that susceptibility breakpoints forH. influenzae should be considerably lower than the current ones for both cefaclor and azithromycin for AOM caused by H. influenzae.

scholarly journals Activity of Faropenem against Middle Ear Fluid Pathogens from Children with Acute Otitis Media in Costa Rica and Israel

2007 ◽  
Vol 51 (6) ◽  
pp. 2230-2235 ◽  
Author(s):  
Kimberley Clawson Stone ◽  
Ron Dagan ◽  
Adriano Arguedas ◽  
Eugene Leibovitz ◽  
Elaine Wang ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Costa Rica ◽  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Streptococcus Pyogenes ◽  
Middle Ear ◽  
Moraxella Catarrhalis ◽  
Acute Otitis Media ◽  
The Other ◽  
Middle Ear Fluid

ABSTRACT Faropenem was tested against 1,188 middle ear fluid pathogens from children in Israel and Costa Rica. Against Streptococcus pneumoniae and Haemophilus influenzae, faropenem was the most active β-lactam, with activity that was similar to or greater than of the other oral antimicrobial classes studied. Faropenem was also active against Moraxella catarrhalis and Streptococcus pyogenes.

Failure of antibiotic therapy in acute otitis media

2003 ◽  
Vol 117 (3) ◽  
pp. 173-176 ◽  
Author(s):  
Emmanuel Babin ◽  
Vincent Lemarchand ◽  
Sylvain Moreau ◽  
Marc Goullet de Rugy ◽  
André Valdazo ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Antibiotic Therapy ◽  
Otitis Media ◽  
Middle Ear ◽  
Acute Otitis Media ◽  
Bacterial Strains ◽  
Middle Ear Fluid ◽  
Two Samples ◽  
Microbiological Techniques

The aim of this retrospective study was to determine the possible causes of failure of antibiotic therapy in children with acute otitis media (AOM). Thirty-nine samples of middle-ear fluid were obtained by myringotomy from 31 children suffering from AOM, unrelieved by antibiotic therapy administered for over 48 hours. The samples were analysed by the usual microbiological techniques, including cultures, tests for beta-lactamase producing strains and the determination of the minimal inhibitory concentration of penicillin for Streptococcus pneumoniae. In 14 samples, no bacterial strains were detected in the cultures of middle-ear fluid; and in two samples the cultures revealed two strains of bacteria. The bacteria most frequently identified were Haemophilus influenzae, found in 11 samples, and Streptococcus pneumoniae, found in seven samples, of which four produced strains with reduced susceptibility to penicillin. The failure of antibiotic therapy in AOM appears to be related to the increased resistance of Haemophilus influenzae and to the reduced susceptibility of Streptococcus pneumoniae to penicillin. Other factors contributing to the failure of antibiotic therapy in AOM may be the viruses or the bacteria that produce multiple pathogens in the middle ear.

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