Predictive value of neutrophil-to-lymphocyte ratio in diagnosis of early prostate cancer among men who underwent robotic transperineal prostate biopsy

Abstract Background NLR is known to have prognostic value for metastatic prostate cancer (PCa). However for early PCa due to lack of systemic response; the role of NLR is not conclusive. In this study we aim to evaluate the predictive value of NLR for early clinical PCa in patients who underwent robotic transperineal prostate biopsy (RTPB). Methods Patients who underwent RTPB under general anesthesia (GA), at the Department of Urology, Singapore General Hospital between Sep 2006 and Feb 2016 were retrospectively reviewed. Exclusion criteria includes: 1. Patients with missing value of PSA NLR 2. Patients who underwent biopsy for non-diagnostic purposes. 3. Patients with chronic inflammation or high grade prostatic intraepithelial neoplasia. Patients who had more than one biopsies and only the last histology results were included in this study. NLR was calculated for all patients using Complete blood count that was done as pre-admission test before GA within 4 weeks before operation. NLR values were compared between PCa; clinical significant PCa and benign group. Patients were divided further into different groups according to PSA level for subgroup analysis. Results A total 652 patients who underwent RTPB for diagnostic purpose with valid pre-procedure PSA level were included in this study. There were total 409 (62.7%) benign histology and 243 (37.3%) PCa cases. Median NLR in the benign histology group and PCa group were 2.00 and 1.99. There was no statistically significant (P=0.29). In the subgroups analysis, there were also no significant difference of median NLR value in clinical significant cancer group (defined as Gleason 3 + 4 and above) when compared to benign group (NLR 2.00 vs. 2.01, P=0.41) as well as in prostate cancer group and benign group according to different pre-biopsy PSA levels (PSA < 4, 4-10, 10-20 and > 20 ug/L), respectively. (P>0.05). NLR is not a significant predictor for Gleason grade group and D’Amico risk stratification group. (P>0.05) Conclusion There were no statistical significant difference of NLR between benign and prostate cancer group as a whole or in the subgroup analyses for patients who underwent RTPB. NLR may have a limited role in predicting early prostate cancer.

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Predictive value of neutrophil-to-lymphocyte ratio in diagnosis of prostate cancer among men who underwent template-guided prostate biopsy

Medicine ◽

10.1097/md.0000000000005307 ◽

2016 ◽

Vol 95 (44) ◽

pp. e5307 ◽

Cited By ~ 5

Author(s):

Tian-bao Huang ◽

Shi-yu Mao ◽

Sheng-ming Lu ◽

Jun-jie Yu ◽

Yang Luan ◽

...

Keyword(s):

Prostate Cancer ◽

Prostate Biopsy ◽

Predictive Value ◽

Neutrophil To Lymphocyte Ratio ◽

Lymphocyte Ratio

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Predictive value of neutrophil-to-lymphocyte ratio in diagnosis of early prostate cancer among men who underwent Robotic transperineal prostate biopsy

10.21203/rs.2.12296/v1 ◽

2019 ◽

Author(s):

Du Jingzeng ◽

Ee Jean Lim ◽

Hong Hong Huang ◽

Weber Kam On Lau

Keyword(s):

Prostate Cancer ◽

Prostate Biopsy ◽

Predictive Value ◽

Full Blood Count ◽

Diagnostic Purpose ◽

Transperineal Prostate Biopsy ◽

Cancer Group ◽

Significant Difference ◽

Benign Histology ◽

Benign Group

Abstract Background： NLR is known to have prognostic value for metastatic prostate cancer. However for early-localized prostate cancer due to lack of systemic response; the role of NLR is not conclusive. In this study we aim to evaluate the predictive value of NLR for early clinical indolent prostate cancer in patients who underwent robotic transperineal prostate biopsy (RTPB). Methods: Patients who underwent RTPB under general anesthesia, at Urology Department, Singapore General Hospital between Sep 2006 and Feb 2016 were retrospectively reviewed. NLR was calculated for all patients using full blood count (FBC) that was done as pre-admission test before GA within 4 weeks before operation. And NLR values were compared between prostate cancer (PCa) and benign group. Results: A total 652 patients who underwent RTPB for diagnostic purpose with valid PSA level were included in this study. There were total 409 (62.7%) benign histology and 243 (37.3%) prostate cancer. There was no significant difference of median NLR between benign and prostate cancer group (2.00 vs. 1.99; P=0.29). In the subgroups analysis, there were also no significant difference of median NLR value in clinical significant cancer (defined as Gleason 3 + 4 and above) and benign histology group (NLR 2.00 vs. 2.01, P=0.41), as well as prostate cancer and benign group according to different pre-biopsy PSA levels: PSA (ug/l) < 4, 4-10,10-20 and > 20, respectively. (Median NLR 1.34 vs. 1.76; 1.97 vs. 1.97; 1.97 vs. 2.18; 2.18 vs. 1.98, P>0.05) Conclusion: There were no statistical significant difference of NLR between benign and prostate cancer group as a whole or in the subgroup analyses for patients who underwent robotic transperineal prostate biopsy. NLR may have a limited role in predicting early stage prostate cancer.

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Association of the neutrophil-to-lymphocyte ratio (NLR) and prostate cancer detection rates in patients via contemporary multi-core prostate biopsy

Asian Journal of Andrology ◽

10.4103/1008-682x.164198 ◽

2015 ◽

Vol 0 (0) ◽

pp. 0

Author(s):

JongJin Oh ◽

Ohsung Kwon ◽

JungKeun Lee ◽

Seok-Soo Byun ◽

SangEun Lee ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Detection ◽

Prostate Biopsy ◽

Neutrophil To Lymphocyte Ratio ◽

Detection Rates ◽

Prostate Cancer Detection ◽

Lymphocyte Ratio

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Predictive value of preoperative neutrophil-to-lymphocyte ratio in localized prostate cancer: results from a surgical series at a high-volume institution

Minerva Urology and Nephrology ◽

10.23736/s2724-6051.20.03662-0 ◽

2021 ◽

Vol 73 (4) ◽

Author(s):

Carlo A. BRAVI ◽

Giuseppe ROSIELLO ◽

Giuseppe FALLARA ◽

Emily VERTOSICK ◽

Amy TIN ◽

...

Keyword(s):

Prostate Cancer ◽

Predictive Value ◽

High Volume ◽

Neutrophil To Lymphocyte Ratio ◽

Localized Prostate Cancer ◽

Lymphocyte Ratio

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The role of blood neutrophil count and the neutrophil-to-lymphocyte ratio as a predictive factor for prostate biopsy results

Urologia Journal ◽

10.1177/0391560318766822 ◽

2018 ◽

Vol 85 (4) ◽

pp. 158-162 ◽

Cited By ~ 1

Author(s):

Koosha Kamali ◽

Mojtaba Ashrafi ◽

Pejman Shadpour ◽

Mojtaba Ameli ◽

Amirmahdi Khayyamfar ◽

...

Keyword(s):

Prostate Cancer ◽

Prostate Specific Antigen ◽

Neutrophil Count ◽

Prostate Biopsy ◽

Predictive Factor ◽

Specific Antigen ◽

Digital Rectal Examination ◽

Neutrophil To Lymphocyte Ratio ◽

Blood Neutrophil ◽

Lymphocyte Ratio

Background: It is apparent that prostate cancer has harmful effects on the erythrocytes, leucocytes, and platelets. In addition, it has been suggested that the toxic granules in neutrophils lead to inflammation in the cancerous tissues besides the activation of monocytes, so in this study we aimed to evaluate the blood neutrophil count besides the neutrophil-to-lymphocyte ratio as a predictive factor for prostate biopsy results and their relationship with prostate cancer grade in patients undergoing biopsy of the prostate. Methods: For all men with irritative lower urinary tract symptoms visiting Hasheminezhad Hospital from January to July 2015, in case of having a suspicious digital rectal examination or aged above 40 years, prostate-specific antigen was requested and in case of abnormal results, they underwent prostate biopsy. In order to examine the study hypothesis, the blood neutrophil count and the neutrophil-to-lymphocyte ratio were measured and compared with the abnormal prostate-specific antigen results and suspicious digital rectal examination. Results: Among the 500 referred samples for biopsy, 352 (70.4%) had a negative biopsy result, while it was positive in the other 148 (29.6). The mean neutrophil count showed no statistical difference regarding the biopsy results (p = 0.381). When measuring the neutrophil-to-lymphocyte ratio again with biopsy results, no statistically significant difference was obtained based on the biopsy results (p = 0.112). Conclusion: Neutrophil count and neutrophil-to-lymphocyte ratio cannot be predictive factors for positive prostate cancer biopsy.

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