Assessment of adrenal response in patients with stable cirrhosis and ascites using different short Synachten tests and definitions

ABSTRACT The in vitro resin uptake of 3H-prednisolone was used for the determination of blood cortisol after addition of radioactive prednisolone followed by Amberlite CG 400 Type 1 to the test serum, and incubation of the mixture. The radioactivity of the supernatant was compared before and after the addition of the resin. The principle of this method is similar to that of the 131I-triiodothyronine resin uptake for the thyroid function test. The tests for the specificity, reproducibility and sensitivity gave satisfactory results. The mean basal value ± SD of the 3H-prednisolone resin uptake was 35.3 ± 9.2% in normal subjects, and 27.1 ± 4.8% in pregnant women. This method was valid in various adrenal function tests, i. e. the adrenal circadian rhythm, corticotrophin (ACTH) test, dexamethasone suppression test and the adrenal response to lysine-8-vasopressin. It proved to be a sensitive indicator of the adrenal function. These results suggest that this method should be useful for a routine adrenal function test.

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Neurochemical activity of noradrenergic neurons and pituitary-adrenal response after naloxone-induced withdrawal: the role of calcium channels

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/pl00004975 ◽

1997 ◽

Vol 355 (4) ◽

pp. 501-506 ◽

Cited By ~ 26

Author(s):

M. L. Vargas ◽

M. G. Martínez-Piñero ◽

M. V. Milanés

Keyword(s):

Calcium Channels ◽

Noradrenergic Neurons ◽

Adrenal Response

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EFFECT OF AN ANABOLIC STEROID (METHANDIENONE) ON PITUITARY-ADRENAL FUNCTION IN THE HUMAN

Journal of Endocrinology ◽

10.1677/joe.0.0250199 ◽

1962 ◽

Vol 25 (2) ◽

pp. 199-209 ◽

Cited By ~ 19

Author(s):

V. WYNN ◽

J. LANDON ◽

V. H. T. JAMES

Keyword(s):

Anorexia Nervosa ◽

Anabolic Steroid ◽

Adrenal Glands ◽

Suppressive Effect ◽

Adrenal Function ◽

Endocrine Diseases ◽

Adrenal Response ◽

Steroid Excretion ◽

Urinary Steroid ◽

Marked Suppression

SUMMARY The effect of methandienone administration on urinary steroid excretion has been studied in subjects with normal pituitary-adrenal function and in patients with various endocrine diseases. In the control subjects, a marked suppression of urinary 17-KS and 17-OHCS excretion occurred, which persisted throughout even prolonged periods of methandienone administration. Upon cessation of methandienone treatment a prompt rise in urinary steroid excretion occurred, on occasions to levels slightly higher than those seen before treatment. Similar results were obtained in subjects with acromegaly and Cushing's syndrome, but in patients with anorexia nervosa and a low basal steroid excretion, the suppressive effect of methandienone was less marked. During treatment with methandienone, pituitary response to metopirone was depressed, but adrenal response to corticotrophin was unaltered. It was concluded that methandienone diminishes the rate of production of adrenocortical steroid by inhibiting corticotrophin production or release. Unlike the inhibition observed during treatment with glucocorticoids, it was not associated with atrophy of the adrenal glands.

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Chronic Intermittent Cold Stress Sensitises the Hypothalamic-Pituitary-Adrenal Response to a Novel Acute Stress by Enhancing Noradrenergic Influence in the Rat Paraventricular Nucleus

Journal of Neuroendocrinology ◽

10.1111/j.1365-2826.2005.01372.x ◽

2005 ◽

Vol 17 (11) ◽

pp. 761-769 ◽

Cited By ~ 62

Author(s):

S. Ma ◽

D. A. Morilak

Keyword(s):

Cold Stress ◽

Paraventricular Nucleus ◽

Acute Stress ◽

Hypothalamic Pituitary Adrenal ◽

Adrenal Response

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Adrenal response to glucocorticoid treatment

The Lancet ◽

10.1016/s0140-6736(05)74650-x ◽

2000 ◽

Vol 355 (9213) ◽

pp. 1458

Author(s):

Dominique Vanpee ◽

Jean-Bernard Gillet

Keyword(s):

Glucocorticoid Treatment ◽

Adrenal Response

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Effects of age and maternal reactivity on the stress response of the pituitary-adrenocortical axis and the sympathetic nervous system in neonatal pigs

Animal Science ◽

10.1017/s1357729800050542 ◽

1999 ◽

Vol 68 (3) ◽

pp. 519-526 ◽

Cited By ~ 27

Author(s):

E. Kanitz ◽

W. Otten ◽

G. Nürnberg ◽

K. P. Brüssow

Keyword(s):

Stress Reactivity ◽

Acth Stimulation Test ◽

Acth Stimulation ◽

Acth Challenge ◽

Neonatal Pigs ◽

Age Related ◽

Highly Sensitive ◽

Function Test ◽

Adrenal Response ◽

Different Levels

AbstractThe study was conducted to investigate the adreno cortical capacity after injection of ACTH and the sensitivity of the pituitary and the adrenal to immobilization in neonatal pigs at different ages. Furthermore, the endocrine reactivity of the offspring was compared with the stress reactivity of their mothers. Four piglets were selected from each of six different litters and subjected to an immobilization test and an adrenal function test using synthetic ACTH1-24 at the ages of 7, 21 and 35 days; the six sows were also subjected to restraint and an ACTH stimulation test. Plasma β-endorphin, norepinephrine and epinephrine concentrations were measured in blood samples taken 2 min after restraint and cortisol concentrations were measured 60 min after ACTH administration. A highly sensitive adrenal response was demonstrated in both sows and piglets and adrenal reactivity showed also a considerable consistency over time within sows. In neonatal pigs, the cortisol response to ACTH was greatest on day 7 and decreased up to day 35. Plasma epinephrine and norepinephrine levels after the 2-min immobilization were also higher at day 7 compared with the other ages (P < 0·01). Piglets from sows, classified as high reacting according to their cortisol or epinephrine response, also showed significantly higher cortisol levels after ACTH challenge at all ages and significantly higher epinephrine levels after restraint at day 7 than piglets from low reacting sows. The results show an age-related change of pituitary-adrenocortical and sympatho-adrenomedullary responses in neonatal pigs and an absence of a stress hyporesponsive period at all ages studied. The results also indicate different levels of excitability in the offspring depending on the maternal stress reactivity.

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