Vascular Pattern and Spectral Parameters of Power Doppler Ultrasound as Predictors of Malignancy Risk in Thyroid Nodules

2008 ◽  
Vol 118 (12) ◽  
pp. 2182-2186 ◽  
Author(s):  
Mehdi Bakhshaee ◽  
Yasamin Davoudi ◽  
Mostafa Mehrabi ◽  
Parvin Layegh ◽  
Saadat Mirsadaee ◽  
...  
Keyword(s):  
Doppler Ultrasound ◽  
Thyroid Nodules ◽  
Power Doppler ◽  
Vascular Pattern ◽  
Power Doppler Ultrasound ◽  
Spectral Parameters ◽  
Malignancy Risk

scholarly journals Diagnostic value of 3D power Doppler ultrasound in the characterization of thyroid nodules

2019 ◽  
Author(s):  
AYŞEGÜL CANSU ◽  
EMİN AYAN ◽  
SİBEL KUL ◽  
İLKER EYÜBOĞLU ◽  
ŞÜKRÜ OĞUZ ◽  
...  
Keyword(s):  
Doppler Ultrasound ◽  
Thyroid Nodules ◽  
Power Doppler ◽  
Diagnostic Value ◽  
Flow Index ◽  
Power Doppler Ultrasound ◽  
Diagnostic Efficacy ◽  
3D Power Doppler ◽  
Benign Nodules

Background/aim: To evaluate the diagnostic value of vascular indices obtained using 3D power Doppler ultrasound (3DPDUS) in differentiation of benign and malignant thyroid nodules. Materials and methods: Sixty-seven patients (56 female, 11 male, mean age 44.6) with 81 thyroid nodules exhibiting mixed (peripheral and central) vascularization patterns and with the largest diameter of between 10 mm and 30 mm were prospectively evaluated using 3DPDUS. Nodule volume, vascularization index (VI), flow index (FI) and vascularization flow index (VFI) were calculated using Virtual Organ Computer-aided Analysis (VOCAL) software, and these indices were then compared with regard to the cyto-histopathology-based diagnosis. The optimum cutoff values for the differentiation of benign and malignant nodules were identified, and diagnostic efficacy was calculated using receiver operating characteristic (ROC) analysis. Results: Fifty-six of the 81 nodules included in this study were diagnosed as benign and 25 as malignant. Vascular indices in malignant nodules were significantly higher than those in benign nodules (p<0.05). In benign nodules, mean VI was 11.61 ± 6.88, mean FI was 39.75 ± 3.93 and VFI was 4.82 ± 2.94, compared to 18.64 ± 12.81, 41.82 ± 4.43 and 8.17 ± 6.37, respectively, in malignant nodules. The area under the curves (AUCs) were calculated as 0.68, 0.61 and 0.67 for VI, FI and VFI, respectively. At optimal cut-off values of 10.2 for VI, 40.8 for FI and 5.5 for VFI, sensitivity and specificity were 72%/55.4%, 68%/57.1% and 68%/67.9%, respectively. Conclusion: 3DPDUS could be useful in the characterization of thyroid nodules. Key words: Thyroid nodules; three-dimensional power Doppler ultrasound; vascular indices; VOCAL

scholarly journals Role of Duplex Power Doppler Ultrasound in Differentiation between Malignant and Benign Thyroid Nodules

2010 ◽  
Vol 11 (6) ◽  
pp. 594 ◽  
Author(s):  
Oktay Algin ◽  
Efnan Algin ◽  
Gokhan Gokalp ◽  
Gokhan Ocakoğlu ◽  
Cüneyt Erdoğan ◽  
...  
Keyword(s):  
Doppler Ultrasound ◽  
Thyroid Nodules ◽  
Power Doppler ◽  
Power Doppler Ultrasound ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

scholarly journals OP0178 IMAGING NEOANGIOGENESIS IN RHEUMATOID ARTHRITIS (INIRA): WHOLE-BODY SYNOVIAL UPTAKE OF A 99MTC-LABELLED RGD PEPTIDE IS HIGHLY CORRELATED WITH POWER DOPPLER ULTRASOUND

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 110.2-111
Author(s):  
L. Attipoe ◽  
S. Subesinghe ◽  
C. Blanco-Gil ◽  
M. Opena ◽  
M. Rosser ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Correlation Coefficient ◽  
Doppler Ultrasound ◽  
Imaging Modality ◽  
Power Doppler ◽  
Whole Body ◽  
Total Power ◽  
Acquisition Time ◽  
Power Doppler Ultrasound ◽  
Highly Correlated

Background:Power Doppler ultrasound (PDUS) is superior to clinical examination in detecting synovitis in patients with rheumatoid arthritis (RA). Although dynamic and cheap it is impractical to scan large numbers of joints in routine clinical settings. MRI, whilst sensitive for synovitis, is expensive and routine use is limited to targeted joints. Bone scintigraphy produces whole body images but due to limited specificity is not routinely used.99mTc-maraciclatide (Serac Healthcare) is a radiolabelled tracer which binds with high affinity to integrin αvβ3, a cell-adhesion molecule up-regulated on neoangiogenic blood vessels. It therefore has the potential to image synovial inflammation at the whole-body level. We previously showed in a pilot study that uptake was seen in the inflamed joints of five RA patients and that this correlated with PDUS. This study explores correlation with PDUS in a larger groups of patients with varied disease activity.Objectives:To determine the correlation between ultrasound and99mTc-maraciclatide imaging in patients with rheumatoid arthritis.Methods:50 patients with RA fulfilling ACR 2010 classification criteria were recruited. Patients underwent an ultrasound scan of 40 joints with grey scale (GS) and PD quantification. Each joint was scored on a scale of 0-3 for GS and PD with a total score calculated for each patient. Within 3 hours of the ultrasound patients were injected with 740 MBq of99mTc-maraciclatide. Using a gamma camera, whole body planar views and dedicated hand and foot views were taken 2 hours after injection (Figure 1). Acquisition time was 20 minutes for whole body and 20 minutes for hand and foot views.99mTc-maraciclatide images were scored as positive or negative uptake for each joint (binary score). A quantitative score was also calculated for each joint where there was uptake with this corrected for background uptake. Total binary and quantitative scores per patient were calculated.Ultrasound and99mTc-maraciclatide scores were tested for correlation with Pearson’s correlation coefficient (r). Interrater agreement for 2 scorers was calculated using kappa (ĸ) and concordance correlation coefficient (Pc).Results:Strong correlation was seen when total PDUS was compared to binary scores (r=0.92, r2=0.85) (Figure 2) and quantitative scores (r=0.85, r2=0.72). ĸ was 0.82 and 0.79 for binary and ultrasound scores respectively.Pcwas 0.82 for quantitative scores. p was <0.0005 for all results.99mTc-maraciclatide uptake was also seen in inflamed tendons/tendon sheaths. The imaging procedure was well-tolerated. There were no tracer-related adverse events.Figure 1.99mTc-maraciclatide imaging with dedicated hand and foot viewsConclusion:99mTc-maraciclatide uptake was highly correlated with PDUS highlighting its potential as an alternative imaging modality.99mTc-based planar imaging has the unique capacity to image the whole body and hence the total synovial inflammatory load in a quick acquisition. The imaging equipment to perform these scans is already widely available in radiology departments. Interpretation of scans is also much simpler compared to US/MRI. It could therefore have a role in key decision-making points in pathways for diagnosis, treatment failure, and remission prior to dose tapering.Figure 2.Correlation between total power doppler and99mTc-maraciclatide binary scoresDisclosure of Interests:None declared

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