This chapter discusses the use of yoga-based interventions for the treatment of posttraumatic stress disorder (PTSD). It will first provide an overview of the empirical research on yoga and other mindfulness-based interventions for individuals with anxiety, depression, and PTSD. Potential mechanisms of action in yoga interventions will be discussed, including mindfulness, breathing, positive emotions and social cohesion, meaning-making, spirituality, and cognitive restructuring. Although effective evidence-based interventions for PTSD such as exposure-based therapies are available, some individuals are reticent to engage in exposure therapy, have limited access to health care, or continue to experience symptoms after receiving treatment. Thus, yoga-based interventions have potential as an affordable, easily accessible alternative or complement to existing treatments. Although there is preliminary evidence supporting the use of yoga-based interventions, further research with sufficient sample sizes and rigorous research designs is needed.