The functions and roles of sestrins in regulating human diseases

Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect organisms against various noxious stimuli including DNA damage, oxidative stress, starvation, endoplasmic reticulum (ER) stress, and hypoxia. Sesns regulate metabolism mainly through activation of the key energy sensor AMP-dependent protein kinase (AMPK) and inhibition of mammalian target of rapamycin complex 1 (mTORC1). Sesns also play pivotal roles in autophagy activation and apoptosis inhibition in normal cells, while conversely promoting apoptosis in cancer cells. The functions of Sesns in diseases such as metabolic disorders, neurodegenerative diseases, cardiovascular diseases, and cancer have been broadly investigated in the past decades. However, there is a limited number of reviews that have summarized the functions of Sesns in the pathophysiological processes of human diseases, especially musculoskeletal system diseases. One aim of this review is to discuss the biological functions of Sesns in the pathophysiological process and phenotype of diseases. More significantly, we include some new evidence about the musculoskeletal system. Another purpose is to explore whether Sesns could be potential biomarkers or targets in the future diagnostic and therapeutic process.

Religiosity and spirituality in mental health: nurses’ training, knowledge and practices

ABSTRACT Objective: to analyze nurses’ training, knowledge and practices in the religiosity/spirituality interface in the context of Psychosocial Care Centers. Methods: a descriptive, exploratory, qualitative study, carried out in a metropolitan region of Ceará. Four nurses were interviewed, and the data were examined using the content analysis technique. Results: four categories emerged from analysis: Deficit in teaching religious and spiritual practices in higher education in nursing; View of the concept of religiosity and spirituality; Religiousness and spirituality as an integral part of the person; Reception of religious and spiritual practices as an aid to treatment. Final considerations: a deficit in nursing undergraduate teaching was identified concerning religiosity and spirituality. However, the interviewed professionals understand the importance of religious and spiritual dimensions in the therapeutic process, even though they do not accurately differentiate the concepts.

Contemporary Art in Applied Dimensions: A Reflective Review of Art as Therapeutic Process

A common perception about contemporary art is the perception that it excludes a majority of people as being its legitimate viewers or judges, by virtue of the fact that it contains exclusive or encrypted messages. A small, privileged group of experts grant value, acceptance and endow public popularity of such works for the market and media. In this research we seek to provide an insight into a cluster of contemporary abstract art forms and show how such art forms anticipate closer and more common sensory and hermeneutic experience. Art like that of Hamish Fulton is built on experiences that enables us to connect with them, thereby redefining the concepts and ideas of these arts through an alternative phenomenological experience of their methods and processes of making art. Fulton’s art is based on a visual translation of his experiences of healing walks through mountainous terrain. We may build a personal, general methodology of interpretation by building personal synergistic links with the methods of creation – that could in turn generate therapeutic effects both in the viewer or in the interpreter of such art, through self-reflection and re-construction of the concepts proposed in the framing. Likewise, we will reflect briefly on art therapeutic projects that we studied for patients with ADHD. We analyze the expressions and suggest a method of therapeutic art creation based on similar processes as in Fulton.

The antidepressants effects on microbiota: unobvious possibilities Research article

Despite the emergence of new antidepressants with different mechanisms of action, a large number of problems in antidepressant therapy remain. Considering the known antimicrobial activity of antidepressants, the role of the microbiota in the thymoanaleptic activity of these drugs is of high interest. In recent years, important data have been obtained on the role of the gut microbiota in the regulation of behavior and the pathophysiology of a number of mental disorders, including depression. Of particular interest is the assessment of the normal intestinal microbiota role in the course of the therapeutic process. The emerging bi-directional interactions between drugs and microorganisms may be critical for personalized drug selection and future drug development. However, at the present time, this problem remains poorly understood. The proposed manuscript articulates the main directions that are of clinical importance and can become an object for further study in this area.The research results indicate that the effect of antidepressants on the microbiota is a promising area, the study of which could provide many important findings for clinical practice. This type of therapeutic manipulation can provide an opportunity for intervention in order to potentiate the activity of antidepressants or to minimize side effects. The problem with this method of intervention is enormous complexity, when manipulations can have both positive and negative effects simultaneously, depending on different strains of microorganisms influencing different therapeutic effects. More research is needed to understand what changes occur in the microbiome with acute and chronic administration of specific antidepressants. Perhaps this will contribute to the development of microbiomodulatory tactics for individualized interventions.

Wounded by reality: emotional deprivation and unresolved trauma in psychoanalytical couple’s therapy

In this article, I will focus on highly conflictual couples with extensive emotional deprivation and unresolved trauma, which prevents them from developing healthy romantic relationships and overcoming the challenges entailed in any intimate attachment. I will describe how everyday interactions are experienced as threatening or even lethal movements between the partners. The question which arises in the psychoanalytical therapeutic process is how to help the couple tolerate the sensory reminders of the unresolved trauma as a necessary precursor to any process of symbolisation. In order to provide a safe enough therapeutic attachment bond, extensive time is dedicated to the emotional experience of self and the other in the here-and-now of the session, which validates the emotional experience of the couple as well as contains it. The therapy focuses on the transferential and countertransferential movements inspired by the matrix of the victim, abuser, and uninvolved witness (Davies & Frawley, 1994) to elaborate the intertwining of the unresolved trauma with the couple’s form of attachment. In order to illustrate my argument, I present two examples: one from a fictional narration and another from my clinical work.

Alternative Fish Species for Nutritional Management of Children with Fish-FPIES—A Clinical Approach

In the Mediterranean region, fish is a common cause of food protein-induced enterocolitis syndrome (FPIES) in children. No laboratory tests specific to FPIES are available, and oral food challenge (OFC) is the gold standard for its diagnosis and testing for achievement of tolerance. Children with FPIES to fish are usually advised to avoid all fish, regardless of the species. Fish are typically classified into bony and cartilaginous, which are phylogenetically distant species and therefore contain less cross-reacting allergens. The protein β-parvalbumin, considered a pan-allergenic, is found in bony fish, while the non-allergenic α-parvalbumin is commonly found in cartilaginous fish. Based on this difference, as a first step in the therapeutic process of children with FPIES caused by a certain fish in the bony fish category (i.e., hake, cod, perch, sardine, gilthead sea bream, red mullet, sole, megrim, sea bass, anchovy, tuna, swordfish, trout, etc.), an OFC to an alternative from the category of cartilaginous fish is suggested (i.e., blue shark, tope shark, dogfish, monkfish, skate, and ray) and vice versa. Regarding the increased mercury content in some sharks and other large species, the maximum limit imposed by the European Food Safety Authority (EFSA) for weekly mercury intake must be considered. An algorithm for the management of fish-FPIES, including alternative fish species, is proposed.

In and Out of Sync: an Example of Gestalt Therapy

This article emphasizes the importance of synchronization in changing patients’ dysfunctional patterns of thoughts, feelings, and behaviors to functional ones. Furthermore, the concept of synchronization in psychotherapy is delineated herein, showing its feasibility through the free energy principle. Most sync-oriented publications focus on the therapist-patient relationship. In contrast, this article is focusing on the therapeutic process, especially by analyzing how dysfunctional units—both in an individual’s mind, as well as in social relationships—assemble in synchrony and how psychotherapy helps to disassemble and replace them with functional units. As an example, Gestalt psychology and Gestalt psychotherapy are demonstrated through the lenses of synchronization, supported by diverse case studies. Finally, it is concluded that synchronization is opening a gateway to understanding the change dynamics in psychotherapy and, as such, is worth further study.

Slasher therapy: the slasher movie as an allegory for uncovering trauma

This study aims at analyzing slasher films as potential allegories for the therapeutic process of uncovering trauma, proposing a reading of the slasher killer as a metaphor for the trauma. To perform this analysis, the plots of the movies A Nightmare on Elm Street (Bayer, 2010) and Final Girls (Schulsson, 2015), were read as possible allegories for a psychoanalytical process in which their final girls come to terms with trauma as they face the killers. This analysis is performed based on the slasher film structure as composed by Final Girl versus Slasher killer, as defined by Carol Clover (1992), and, as their confrontation takes place in what Clover calls the Terrible place, that is compared to the unconscious and its dynamics, as proposed by Sigmund Freud’s The Ego and the Id (2019). The correlation of trauma and fictional narratives is performed based on Cathy Caruth’s (1996) studies of trauma and the construction of narratives.

The multiple sclerosis patient’s journey model in Poland – future tasks

Improvement of the diagnostic and therapeutic processes and optimal use of resources in the context of health care system specificity accelerate the diagnosis and treatment onset, as well as improve the quality of life of patients with multiple sclerosis. International experience and data from clinical practice in Poland gave rise to a number of guidelines for the needed measures, from increasing the awareness about multiple sclerosis among the society and doctors in general, through expanding outpatient medical care, to proposing a model network of healthcare centres dedicated to patients with multiple sclerosis. It was pointed out that there is a need for a network of clinics specialised in the diagnosis and treatment of multiple sclerosis (MS clinics) and centres for comprehensive diagnosis and treatment, with a higher reference level and all the competences of an MS clinic, and, at the same time, providing both consultations in difficult clinical cases and access to the most advanced diagnostic and therapeutic methods. Attention was also drawn to the need to use modern e-health tools, which should improve the diagnostic and therapeutic process, as well as tighten the coordination of care by enabling an effective exchange of information between the patient and the entire interdisciplinary team involved in the therapeutic process.