Simplified methods for assessment of renal function as the ratio of glomerular filtration rate to extracellular fluid volume

2012 ◽  
Vol 33 (12) ◽  
pp. 1243-1253 ◽  
Author(s):  
Lars Jødal ◽  
Jens Brøchner-Mortensen
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Extracellular Fluid ◽  
Fluid Volume ◽  
Extracellular Fluid Volume

Extracellular fluid volume and glomerular filtration rate

2011 ◽  
Vol 32 (7) ◽  
pp. 649-653 ◽  
Author(s):  
A. Michael Peters ◽  
Daphne M. Glass ◽  
Nicholas J. Bird
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Extracellular Fluid ◽  
Fluid Volume ◽  
Extracellular Fluid Volume

scholarly journals Extracellular fluid volume: A suitable indexation variable to assess impact of bariatric surgery on glomerular filtration rate in patients with chronic kidney disease

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256234
Author(s):  
Caroline Grangeon-Chapon ◽  
Audrey Laurain ◽  
Vincent L. M. Esnault ◽  
Coralie Cruzel ◽  
Antonio Iannelli ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Extracellular Fluid ◽  
Extracellular Fluid Volume ◽  
One Year

Background Bariatric surgery (BS) might be a nephroprotective treatment in obese patients with chronic kidney disease (CKD), and the non-linear relation between body surface area (BSA) and extracellular fluid volume (ECFV) in obese people raises the question of the most relevant way to scale glomerular filtration rate (GFR) for assessing renal function changes after BS. Methods We screened 1774 BS candidates and analysed 10 consecutive participants with CKD stage 3. True GFR (mGFR), measured by the renal clearance of 51Cr-ethylenediaminetetraacetic acid (EDTA), was scaled either to BSA (mGFRBSA) or to ECFV measured by 51Cr-EDTA distribution volume (mGFRECFV) before and one year after BS. Results The 10 candidates for BS had a mean body mass index of 43.3 ± 3.6 kg/m2 and a mean GFR of 48 ± 8 mL/min/1.73 m2. Six participants had a sleeve gastrectomy and four had a Roux-en-Y gastric bypass. One year after BS, ECFV decreased (23.2 ± 6.2 to 17.9 ± 4.3 L, p = 0.001), absolute mGFR was not significantly modified (74 ± 23 versus 68 ±19 mL/min), mGFRBSA did not change significantly (53 ± 18 versus 56 ± 17 mL/min/1.73 m2) whereas mGFRECFV significantly increased (42 ± 13 versus 50 ± 14 mL/min/12.9 L, p = 0.037). The relation between mGFRECFV and mGFRBSA was different from the identity line before (p = 0.014) but not after BS (p = 0.09). Conclusion There is a difference between mGFRBSA and mGFRECFV following BS and the latter might better reflect the adequacy between renal function and corpulence.

Renal haemodynamics of cyclosporin A nephrotoxicity in children with juvenile dermatomyositis

1991 ◽  
Vol 81 (2) ◽  
pp. 153-159 ◽  
Author(s):  
A. M. Peters ◽  
J. Z. Heckmatt ◽  
N. Hasson ◽  
B. L. Henderson ◽  
D. EL-Meleigy ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Cyclosporin A ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Extracellular Fluid ◽  
Fluid Volume ◽  
Extracellular Fluid Volume ◽  
Blood Levels ◽  
Filtration Fraction ◽  
Trough Blood

1. Renal haemodynamics were monitored over an average period of 19 months in 17 children being treated with cyclosporin A. Sixteen had juvenile dermatomyositis and one had chronic polyneuropathy. The dose of cyclosporin A ranged from 2.3 to 8.3 mg day−1 kg−1 (median 4.1 mg day−1 kg−1). 2. Glomerular filtration rate (expressed in terms of extracellular fluid volume), renal blood flow (expressed as a fraction of cardiac output) and filtration fraction were measured by using 99mTc-labelled diethylenetriaminepenta-acetate. They were compared with the dosage and trough blood levels of cyclosporin A, and, in 15 patients receiving prednisolone in addition to cyclosporin A, with steroid dosage. 3. All 17 children had a renogram performed 6 months after starting cyclosporin A treatment. Nine of them also had a renogram before starting cyclosporin A treatment (baseline study), while 13, in addition to their renogram 6 months after starting cyclosporin A treatment, also had at least one further renogram. 4. Glomerular filtration rate/extracellular fluid volume fell slightly but significantly from 0.009 (sd 0.0013) before starting cyclosporin A treatment to 0.0085 (0.002) min−1 (P < 0.01) 6 months after cyclosporin A treatment in the nine children who underwent a baseline study. This was accompanied by a significant (P < 0.001) fall in filtration fraction from 0.108 (0.015) to 0.088 (0.014). However, renal blood flow/cardiac output showed no change. 5. In the 13 children studied beyond 6 months after starting cyclosporin A treatment, there was no further significant overall change in any renal haemodynamic variable. However, throughout this period, trough blood levels of cyclosporin A, which ranged from 20 to 258 ng/ml (median 67 ng/ml), correlated inversely with glomerular filtration rate/extracellular fluid volume, but not with renal blood flow/cardiac output. Furthermore, although a weak correlation between filtration fraction and trough blood levels of cyclosporin A did not reach statistical significance, sequential changes in filtration fraction correlated significantly with corresponding sequential changes in glomerular filtration rate/extracellular fluid volume. 6. We conclude that the predominant mechanism of renal impairment at these relatively low trough blood levels of cyclosporin A is a reversible reduction in filtration fraction.

Sign in / Sign up

Export Citation Format

Share Document