Successful Management of Multiple Liver Metastases From Pancreatic Neuroendocrine Tumor by Hepatic Arterial Administration of Cisplatin Powder

Pancreas ◽  
2007 ◽  
Vol 35 (3) ◽  
pp. 288-290 ◽  
Author(s):  
Hisato Igarashi ◽  
Tetsuhide Ito ◽  
Masahiro Yoshinaga ◽  
Makoto Kodama ◽  
Hiroshi Hayashi ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Neuroendocrine Tumor ◽  
Pancreatic Neuroendocrine Tumor ◽  
Successful Management ◽  
Multiple Liver Metastases ◽  
Cisplatin Powder

scholarly journals Pancreatic neuroendocrine tumor accompanied with multiple liver metastases

2014 ◽  
Vol 6 (8) ◽  
pp. 596 ◽  
Author(s):  
Tomohide Hori ◽  
Kyoichi Takaori ◽  
Shinji Uemoto
Keyword(s):  
Liver Metastases ◽  
Neuroendocrine Tumor ◽  
Pancreatic Neuroendocrine Tumor ◽  
Multiple Liver Metastases

scholarly journals Prolonged survival in a patient with multiple liver metastases from a pancreatic neuroendocrine tumor treated with Peptide Receptor Radiotherapy (PRRT)

Suizo ◽  
2020 ◽  
Vol 35 (1) ◽  
pp. 97-103
Author(s):  
Noritoshi KOBAYASHI ◽  
Takeshi SHIMAMURA ◽  
Yuuma TAKEDA ◽  
Naoki OHKUBO ◽  
Motohiko TOKUHISA ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Neuroendocrine Tumor ◽  
Pancreatic Neuroendocrine Tumor ◽  
Prolonged Survival ◽  
Peptide Receptor ◽  
Multiple Liver Metastases

scholarly journals A Case of Long-term Survivor of Pancreatic Neuroendocrine Tumor with Multiple Liver Metastases

2013 ◽  
Vol 18 (2) ◽  
pp. 62-66 ◽  
Author(s):  
Dong Kee Jang ◽  
Jin Myung Park ◽  
Minjong Lee ◽  
Ji Min Choi ◽  
Young Hoon Choi ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Neuroendocrine Tumor ◽  
Pancreatic Neuroendocrine Tumor ◽  
Multiple Liver Metastases ◽  
Term Survivor

scholarly journals A Case of Ectopic Adrenocorticotropic Hormone-producing Pancreatic Neuroendocrine Tumor with Multiple Liver Metastases

2010 ◽  
Vol 57 (3) ◽  
pp. 229-236 ◽  
Author(s):  
Tatsuya KONDO ◽  
Rina MATSUYAMA ◽  
Hiroshi ASHIHARA ◽  
Yasuto MATSUO ◽  
Kazunari SASAKI ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Neuroendocrine Tumor ◽  
Adrenocorticotropic Hormone ◽  
Pancreatic Neuroendocrine Tumor ◽  
Ectopic Adrenocorticotropic Hormone ◽  
Multiple Liver Metastases

scholarly journals Multiple liver metastases originating from synchronous double cancer of neuroendocrine tumor and rectal cancer: a case report

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Sachie Omori ◽  
Noboru Harada ◽  
Takeo Toshima ◽  
Kazuki Takeishi ◽  
Shinji Itoh ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Case Report ◽  
Liver Metastases ◽  
Neuroendocrine Tumor ◽  
Double Cancer ◽  
Multiple Liver Metastases

Growth factor signaling in pancreatic neuroendocrine tumor metastases.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 256-256
Author(s):  
Brenna Rheinheimer ◽  
Ronald Heimark ◽  
Tun Jie
Keyword(s):  
Liver Metastases ◽  
Neuroendocrine Tumor ◽  
Signaling Pathways ◽  
Surgical Resection ◽  
Metastatic Disease ◽  
Genetic Variants ◽  
Genomic Analysis ◽  
Pancreatic Neuroendocrine Tumor ◽  
Proliferation Index ◽  
Who Grade

256 Background: Pancreatic neuroendocrine tumors (PanNETs) are among one of the fastest growing cancer diagnoses, yet clinical management for patients with metastatic disease is largely empirically based. Currently, surgical resection remains the only curative option; however, surgical resection of metastatic disease may not be feasible. Preliminary genomic analysis of primary PanNETs revealed a complex mutational landscape with four common oncogenic events; but, critical activation pathways of metastatic lesions have yet to be elucidated. Therefore, pan-genomic analysis of metastatic PanNETs is necessary to understand which genes/pathways are deregulated in PanNET metastases for potential therapeutic exploitation. Methods: We initiated a preliminary genomic sequencing study to evaluate mutations in a set of matched primary and metastatic PanNETs to determine genetic variants involved in metastasis to the liver. De-identified FFPE tumor samples were analyzed from patients who underwent surgical resection without receiving preoperative therapy. DNA was isolated and whole exome sequencing was performed using the Nextera Rapid Capture Exome Kit by Illumina on an Illumina HiSeq 2000/2500. The following criteria were used to define genetic variants: bidirectional, non-synonymous, clean mapping in IGV, ≥ 15X coverage, and an alternate allele frequency of 0.3 ≤ x ≤ 0.7. Results: All metastatic PanNETs were classified as WHO grade G2/G3 based on their KI-67 proliferation index. Each primary PanNET contained an average of 102 genetic variants while liver metastases showed an average of 124 genetic variants. MUFFINN and string analysis revealed that primary PanNETs contained enrichment for mutations involved in the PI3K/Akt and Ras signaling pathways while liver metastases showed enrichment for mutations involved in the MAPK and ErbB signaling pathways. Additionally, two-thirds of liver metastases contained somatic mutations in FGFR3. Conclusions: We have discovered novel pathways that have the potential to regulate pancreatic neuroendocrine tumor metastasis along with an innovative signaling pathway that may sustain metastatic growth and survival as well as exploitation for therapeutic potential.

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