scholarly journals Abundant Expression of Lysyl Oxidase-like 2 Protein in Intrahepatic Bile Ducts of Infants With Biliary Atresia

2019 ◽  
Vol 69 (3) ◽  
pp. 344-350
Author(s):  
Stefany Honigbaum ◽  
Qingfeng Zhu ◽  
Andrew Layman ◽  
Robert A. Anders ◽  
Kathleen B. Schwarz
Keyword(s):  
Biliary Atresia ◽  
Bile Ducts ◽  
Lysyl Oxidase ◽  
Intrahepatic Bile Ducts

Cholangitis associated with cystic dilatation of the intrahepatic bile ducts after antireflux valve construction in biliary atresia

2001 ◽  
Vol 17 (2-3) ◽  
pp. 108-110 ◽  
Author(s):  
H. Komuro ◽  
S. Makino ◽  
T. Momoya ◽  
Y. Uehara ◽  
K. Tahara ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Bile Ducts ◽  
Cystic Dilatation ◽  
Intrahepatic Bile Ducts ◽  
Antireflux Valve

scholarly journals Estimated Size of Intrahepatic Bile Ducts Affected in Biliary Atresia Explants

2012 ◽  
Vol 138 (suppl 1) ◽  
pp. A232-A232
Author(s):  
James M. Mitchell ◽  
Robert Cowles ◽  
Roger Moreira
Keyword(s):  
Biliary Atresia ◽  
Bile Ducts ◽  
Intrahepatic Bile Ducts

scholarly journals The Sea Lamprey as an Etiological Model for Biliary Atresia

2015 ◽  
Vol 2015 ◽  
pp. 1-17 ◽  
Author(s):  
Yu-Wen Chung-Davidson ◽  
Chu-Yin Yeh ◽  
Weiming Li
Keyword(s):  
Biliary Atresia ◽  
Liver Diseases ◽  
Bile Ducts ◽  
Sea Lamprey ◽  
Genetic Networks ◽  
Compensatory Mechanisms ◽  
Intrahepatic Bile Ducts ◽  
Adaptive Mechanisms ◽  
Adult Lamprey ◽  
Surgical Treatments

Biliary atresia (BA) is a progressive, inflammatory, and fibrosclerosing cholangiopathy in infants that results in obstruction of both extrahepatic and intrahepatic bile ducts. It is the most common cause for pediatric liver transplantation. In contrast, the sea lamprey undergoes developmental BA with transient cholestasis and fibrosis during metamorphosis, but emerges as a fecund adult with steatohepatitis and fibrosis in the liver. In this paper, we present new histological evidence and compare the sea lamprey to existing animal models to highlight the advantages and possible limitations of using the sea lamprey to study the etiology and compensatory mechanisms of BA and other liver diseases. Understanding the signaling factors and genetic networks underlying lamprey BA can provide insights into BA etiology and possible targets to prevent biliary degeneration and to clear fibrosis. In addition, information from lamprey BA can be used to develop adjunct treatments for patients awaiting or receiving surgical treatments. Furthermore, the cholestatic adult lamprey has unique adaptive mechanisms that can be used to explore potential treatments for cholestasis and nonalcoholic steatohepatitis (NASH).

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