A Pilot Study of Addition of Amifostine to Melphalan, Carboplatin, Etoposide, and Cyclophosphamide With Autologous Hematopoietic Stem Cell Transplantation in Pediatric Solid Tumors–A Pediatric Blood and Marrow Transplant Consortium Study

The number of hematopoietic stem cell transplantation (HSCT) in Brazil is growing rapidly. To better understand the outcomes of HSCT in Brazil, strategies have been developed with the Center for International Blood and Marrow Transplant Research (CIBMTR), using its standardized registry structure and data sharing application. The methods adopted to establish the registry were through efforts to increase the Brazilian centers that report to CIBMTR included training courses for HSCT data managers, the officialization of a multicenter HSCT study using the CIBMTR structure and the partnership between Brazilian Society of Bone Marrow Transplantation (SBTMO) and the CIBMTR. Here we describe the history for establishing the HSCT Brazilian database using the CIBMTR back to center data and present the aggregated results since 2016. We found a significant increase in the numbers of active centers reporting to CIBMTR from 11 in 2016 to 21 in 2020 corresponding to higher numbers of transplants reported to the CIBMTR from 574 to 921 in that period. The model used to generate this national database was effective as it leverages existing infrastructure to assess the activity and outcomes of HSCT in Brazil.

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Impact of T-cell depletion strategies on outcomes following hematopoietic stem cell transplantation for idiopathic aplastic anemia: A study on behalf of the European blood and marrow transplant severe aplastic anemia working party

American Journal of Hematology ◽

10.1002/ajh.25314 ◽

2018 ◽

Vol 94 (1) ◽

pp. 80-86 ◽

Cited By ~ 6

Author(s):

Sujith Samarasinghe ◽

Katherine Clesham ◽

Simona Iacobelli ◽

Giulia Sbianchi ◽

Cora Knol ◽

...

Keyword(s):

Stem Cell ◽

T Cell ◽

Hematopoietic Stem Cell Transplantation ◽

Stem Cell Transplantation ◽

Aplastic Anemia ◽

Cell Transplantation ◽

Working Party ◽

Marrow Transplant ◽

Hematopoietic Stem ◽

Blood And Marrow Transplant

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HEMATOPOIETIC STEM CELL TRANSPLANTATION IN EGYPT CHALLENGES AND SOLUTIONS

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2020.023 ◽

2020 ◽

Vol 12 (1) ◽

pp. e2020023

Author(s):

Hossam Kamel Mahmoud ◽

Gamaleldin Mohamed Fathy ◽

Alaa Elhaddad ◽

Omar Abdelrahman Fahmy ◽

Mohamed Abdelmooti ◽

...

Keyword(s):

Stem Cell ◽

Hematopoietic Stem Cell Transplantation ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Hematopoietic Stem Cell ◽

Marrow Transplant ◽

Hematopoietic Stem ◽

Hematological Disorders ◽

Blood And Marrow Transplant ◽

The Difference

Hematopoietic stem cell transplantation (HSCT) is now an established treatment modality with definitive indications for many hematological disorders. However, this line of treatment requires tremendous resources, and it becomes increasingly difficult for transplanters practicing in the developing world to reconcile the difference between what is possible and what is available. On the basis of 30 years of experience and more than 4250 transplants , this article will focus on the challenges faced our HSCT program and how they were solved. The HSCT program in Egypt started in 1989 on a narrow scale and since that time we faced many challenges.In 1997, the transplant rate increased dramatically with the opening of many HSCT units distributed allover Egypt. Our team is registered in the Center for International Blood and Marrow Transplant Research ,and the number of transplants performed till December 2019 exceeded 4000 cases (60% allogeneic and 40% autologous).

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