scholarly journals Herpes Simplex Virus Suppressive Therapy in Herpes Simplex Virus-2/Human Immunodeficiency Virus-1 Coinfected Women Is Associated With Reduced Systemic CXCL10 But Not Genital Cytokines

2016 ◽  
Vol 43 (12) ◽  
pp. 761-764 ◽  
Author(s):  
Erica Andersen-Nissen ◽  
Joanne T. Chang ◽  
Katherine K. Thomas ◽  
Devin Adams ◽  
Connie Celum ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Suppressive Therapy ◽  
Immunodeficiency Virus ◽  
Simplex Virus ◽  
Herpes Simplex Virus 2 ◽  
Human Immunodeficiency Virus 1

scholarly journals A Modified Zinc Acetate Gel, a Potential Nonantiretroviral Microbicide, Is Safe and Effective against Simian-Human Immunodeficiency Virus and Herpes Simplex Virus 2 InfectionIn Vivo

2013 ◽  
Vol 57 (8) ◽  
pp. 4001-4009 ◽  
Author(s):  
Jessica Kenney ◽  
Aixa Rodríguez ◽  
Larisa Kizima ◽  
Samantha Seidor ◽  
Radhika Menon ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Zinc Acetate ◽  
Potential Candidate ◽  
Content Type ◽  
Immunodeficiency Virus ◽  
Gel Treatment ◽  
Simplex Virus ◽  
Herpes Simplex Virus 2

ABSTRACTWe previously showed that a prototype gel comprising zinc acetate (ZA) in carrageenan (CG) protected mice against vaginal and rectal herpes simplex virus 2 (HSV-2) challenge as well as macaques against vaginal simian-human immunodeficiency virus reverse transcriptase (SHIV-RT) challenge. In this work, we modified buffers and cosolvents to obtain a stable, nearly iso-osmolal formulation and evaluated its safety and efficacy against SHIV-RT and HSV-2.In vitrotoxicity to lactobacilli andCandida albicanswas determined. Macaques were given daily doses of ZA and CG (ZA/CG) or CG alone vaginally for 14 days and challenged with SHIV-RT 24 h later. Mice were challenged vaginally or rectally with HSV-2 immediately after a single gel treatment to measure efficacy or vaginally 12 h after daily gel treatment for 7 days to evaluate the gel's impact on susceptibility to HSV-2 infection. The modified ZA/CG neither affected the viability of lactobacilli orC. albicansnor enhanced vaginal HSV-2 infection after daily ZA/CG treatment. Vaginal SHIV-RT infection of macaques was reduced by 66% (P= 0.006) when macaques were challenged 24 h after the last dose of gel. We observed 60% to 80% uninfected mice after vaginal (P< 0.0001) and rectal (P= 0.008) high-dose HSV-2 challenge. The modified ZA/CG gel is safe and effective in animal models and represents a potential candidate to limit the transmission of HIV and HSV-2.

In vitro effect of oral antiseptics on human immunodeficiency virus-1 and herpes simplex virus type 1

2001 ◽  
Vol 28 (7) ◽  
pp. 610-616 ◽  
Author(s):  
A. A. M. A. Baqui ◽  
Jacqueline I. Kelley ◽  
Mary Ann Jabra-Rizk ◽  
Louis G. DePaola ◽  
William A. Falkler ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Herpes Simplex Virus Type ◽  
Immunodeficiency Virus ◽  
Simplex Virus ◽  
Vitro Effect ◽  
Human Immunodeficiency Virus 1
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