TdT+ T-lymphoblastic Populations Are Increased in Castleman Disease, in Castleman Disease in Association With Follicular Dendritic Cell Tumors, and in Angioimmunoblastic T-cell Lymphoma

2012 ◽  
Vol 36 (11) ◽  
pp. 1619-1628 ◽  
Author(s):  
Robert S. Ohgami ◽  
Shuchun Zhao ◽  
Jane K. Ohgami ◽  
Matthew O. Leavitt ◽  
James L. Zehnder ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Cell Lymphoma ◽  
Follicular Dendritic Cell ◽  
Castleman Disease ◽  
T Cell Lymphoma ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Follicular Dendritic

Follicular Dendritic Cell Immunohistochemical Markers in Angioimmunoblastic T-Cell Lymphoma

2005 ◽  
Vol 13 (4) ◽  
pp. 297-303 ◽  
Author(s):  
Megan L Troxell ◽  
Erich J Schwartz ◽  
Matt van de Rijn ◽  
Douglas T Ross ◽  
Roger A Warnke ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Cell Lymphoma ◽  
Follicular Dendritic Cell ◽  
T Cell Lymphoma ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Immunohistochemical Markers ◽  
Follicular Dendritic

scholarly journals Follicular Dendritic Cell Meshwork in Angioimmunoblastic T-Cell Lymphoma Is Characterized by Accumulation of CXCL13+ Cells

2015 ◽  
Vol 55 (2) ◽  
pp. 61-69 ◽  
Author(s):  
Haruo Ohtani ◽  
Takuya Komeno ◽  
Yoshiko Agatsuma ◽  
Motohiro Kobayashi ◽  
Masayuki Noguchi ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Cell Lymphoma ◽  
Follicular Dendritic Cell ◽  
T Cell Lymphoma ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Follicular Dendritic

scholarly journals Angioimmunoblastic T-Cell Lymphoma: A Questionable Association with Follicular Dendritic Cell Sarcoma

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Daniel Benharroch ◽  
Miriam Zekzer ◽  
Karen Nalbandyan
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Cell Lymphoma ◽  
Follicular Dendritic Cell ◽  
T Cell Lymphoma ◽  
Follicular Dendritic Cell Sarcoma ◽  
Follicular Dendritic Cells ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Dendritic Cell Sarcoma ◽  
Follicular Dendritic

An elderly woman presented with generalized lymphadenopathy, several systemic symptoms, and splenomegaly. An inguinal lymph node excision revealed a compound picture. One aspect of the lymph node morphology, including cells with follicular T-helper cell phenotype, was most consistent with angioimmunoblastic T-cell lymphoma. The other component, revealing spindle cells forming whorls with immunostaining for CD21, CD23, and fascin, might be an integral part of this T-cell lymphoma. However, due to the often massive involvement of the nodal tissue by these follicular dendritic cells, these areas were questionably suggestive of involvement by follicular dendritic cell sarcoma. We raise herein the issue of the borderline area between advanced follicular dendritic cell expansion in angioimmunoblastic T-cell lymphoma and a massive follicular dendritic cell proliferation consistent with follicular dendritic cells sarcoma, in the absence of a genomic analysis.

scholarly journals Peripheral T-Cell Lymphoma With Extensive Dendritic Cell Network Mimicking Follicular Dendritic Cell Tumor

2006 ◽  
Vol 126 (2) ◽  
pp. 230-234 ◽  
Author(s):  
Cindi R. Starkey ◽  
Ayumi I. Corn ◽  
Richard S. Porensky ◽  
David Viswanatha ◽  
Carla S. Wilson
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Cell Lymphoma ◽  
Follicular Dendritic Cell ◽  
Cell Tumor ◽  
T Cell Lymphoma ◽  
Peripheral T Cell Lymphoma ◽  
Cell Network ◽  
Follicular Dendritic Cell Tumor ◽  
Follicular Dendritic

scholarly journals Large B-Cell Lymphoma with T-Cell–Rich Background and Nodules Lacking Follicular Dendritic Cell Meshworks: A Case Report with Complete Response to Chemotherapy and a Review of the Literature

2020 ◽  
Vol 5 (11) ◽  
pp. 561-565
Author(s):  
Walid Shalata ◽  
Ismaell Massalha ◽  
Kayed Al-Athamen
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Complete Response ◽  
Follicular Dendritic Cell ◽  
Large B Cell Lymphoma ◽  
Follicular Dendritic ◽  
Large B Cell

In this report, we describe a 38-year-old male with a very rare type of lymphoma, large B cell lymphoma with T cell-rich background and nodules lacking follicular dendritic cell meshworks (THRLBCL). In 2016 the patient presented hot flashes and night sweats (B-symptoms) and peripheral edema. He was treated with R-CHOP (doxorubicin, vincristine, cyclophosphamide, rituximab and Prednisone) chemotherapy, a Positron emission tomography–computed tomography (PET-CT) scan was performed after four cycles of treatment which showed radiologic complete response and blood test (complete blood count (CBC)) results showed normal ranges. As of September, 2020 he patient remains in complete remission. We searched the literature for descriptions of cases spanning the diagnostic spectrum of THRLBCL and we identified only five cases worldwide. The last reported case was in 2014 with distinctive features that were difficult to classify according to the World Health Organization criteria or previously described variants. Our patient is the sixth case of THRLBCL to be reported. He is the youngest of the reported cases and the first from Israel and the Middle East.

Immature T-Cell Populations in Lymph Nodes of Castleman Disease and Angioimmunoblastic T-Cell Lymphoma Suggest Alternate Sites of T-Cell Development,

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 3238-3238
Author(s):  
Robert S. Ohgami ◽  
Shuchun Chun ◽  
Jane Ohgami ◽  
James L. Zehnder ◽  
Matthew Van de Rijn ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Conflicts Of Interest ◽  
Cell Lymphoma ◽  
Castleman Disease ◽  
T Cell Lymphoma ◽  
Cell Populations ◽  
Lymphoid Tissues ◽  
Anatomic Site ◽  
Angioimmunoblastic T Cell Lymphoma

Abstract Abstract 3238 A central dogma of human immunology is that proliferation of immature T-cells, and their development after release from the bone marrow, occurs in the central thymus. Recently, we identified several patients with aberrant polyclonal immature TdT+ precursor T-cell populations in extra-thymic lymphoid tissues. Here we demonstrate that immature precursor T-cell populations, with a cortical thymocyte phenotype, in fact, are expanded in extra-thymic lymphoid tissues of patients with Castleman disease (P < 0.001; n = 29), and angioimmunoblastic T-cell lymphoma (P = < 0.001; n =31) and increased in cases of Castleman disease in association with follicular dendritic cell sarcoma (Figures 1 and 2). Analysis of the proliferation marker, MiB-1, and the morphologic presence of mitoses reveal that these populations are undergoing extra-thymic proliferation and expansion, arguing against simple release from the central thymus and sequestration in these extra-thymic organs. Finally, these populations of immature T-cells are not associated with a particular anatomic site (i.e. neck or mediastinum). These findings challenge the dogma that proliferation of immature human T-cell populations occurs nearly exclusively in the central thymus and demonstrates that stimulation and significant proliferation of extra-thymic immature T-cells does, and can occur in a subset of patients. Disclosures: No relevant conflicts of interest to declare.

Two Cases of Angioimmunoblastic T-cell Lymphoma Presenting with a Skin Eruption

2012 ◽  
Vol 74 (4) ◽  
pp. 399-404
Author(s):  
Kana KOZONO ◽  
Kazuhiko YAMAMURA ◽  
Toshihiko MASHINO ◽  
Masutaka FURUE ◽  
Hideki ASAOKU ◽  
...  
Keyword(s):  
T Cell ◽  
Skin Eruption ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Angioimmunoblastic T Cell Lymphoma
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