Prevalence of Loss of Expression of DNA Mismatch Repair Proteins in Primary Epithelial Ovarian Tumors

2012 ◽  
Vol 31 (6) ◽  
pp. 524-531 ◽  
Author(s):  
Fang-I Lu ◽  
Cyril Blake Gilks ◽  
Anna-Marie Mulligan ◽  
Paul Ryan ◽  
Ghassan Allo ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Ovarian Tumors ◽  
Dna Mismatch ◽  
Mismatch Repair Proteins

scholarly journals Helicobacter pylori infection and expression of DNA mismatch repair proteins

2008 ◽  
Vol 14 (43) ◽  
pp. 6717 ◽  
Author(s):  
Vahid Mirzaee ◽  
Mahsa Molaei ◽  
Hamid Mohaghegh Shalmani ◽  
Mohammad Reza Zali
Keyword(s):  
Helicobacter Pylori ◽  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Helicobacter Pylori Infection ◽  
Dna Mismatch ◽  
Mismatch Repair Proteins

Evaluation of immunohistochemical expression of mismatch repair proteins in endometrioid and seromucinous borderline ovarian tumors a 10-year experience in a large health care institution.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e17557-e17557
Author(s):  
Hector Chavarria ◽  
Marina Frimer ◽  
Noah D. Kauff ◽  
Veena S. John ◽  
Seema Khutti
Keyword(s):  
Mismatch Repair ◽  
Ovarian Tumors ◽  
Borderline Tumor ◽  
Nuclear Staining ◽  
Immunohistochemical Expression ◽  
Stromal Invasion ◽  
Borderline Tumors ◽  
Dna Mismatch ◽  
Mismatch Repair Proteins

e17557 Background: Borderline tumors (BT) are atypical proliferation of epithelium in the ovary in the absence of destructive stromal invasion, representing for 15% of all epithelial ovarian cancers. [1] Around 10% of the ovarian tumors are hereditary, and approximately 10% of all the hereditary forms of epithelial ovarian tumors are result of a loss of DNA mismatch repair (MMR). [2] Endometrioid borderline tumor (EBT) and Seromucinous borderline tumors (SMBT) are rare tumors in ovary and there is limited literature available on immunohistochemical (IHC) expression of Mismatch repair proteins(MMRP)in these tumors.[3, 4] The aim of this study is to evaluate IHC expression of MMRP in EBT and SMBT of ovary. Methods: Pathology database was searched for ovarian Endometrioid borderline tumor (EBT) and Seromucinous borderline tumor (SMBT) for a 10-year period (2010-2020). The cohort consisted of 10 EBT (6 of which had focal microinvasion or carcinoma) and 12 SMBT(2 of which had focal carcinoma ). For comparison, 1 borderline Brenner. 15 serous borderline tumors (SBT) and 15 mucinous borderline tumors (MBT) were also included. After reviewing slides, a block with adequate borderline tumor was selected for IHC stains. For the cases with carcinoma, two different blocks with each component were selected. In all selected blocks, IHC stains for four MMRP (MLH1, PMS2, MSH2, MSH6) were performed. The complete absence of nuclear staining in tumor cells was considered as “loss” of the MMRP expression. Any “weak” or “focal” nuclear staining was considered intact. Results: Total 53 cases were evaluated for MMRP IHC. All cases had intact MMRP expression. In cases with carcinoma, both components (BT and carcinoma) have intact MMR IHC expression. See table. Conclusions: Our study did not show loss of MMRP IHC expression in EMT or SMBT. However, our study consisted of a small number of cases. Multi Institutional study with a large number of cases can be helpful in future to further evaluate the role of MMRP IHC in EMT and SMBT. [Table: see text]

scholarly journals Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX

Oncogene ◽  
2003 ◽  
Vol 22 (6) ◽  
pp. 819-825 ◽  
Author(s):  
Mary Mac Partlin ◽  
Elizabeth Homer ◽  
Helen Robinson ◽  
Carol J McCormick ◽  
Dorothy H Crouch ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Dna Mismatch ◽  
Mismatch Repair Proteins

scholarly journals C-Terminal Fluorescent Labeling Impairs Functionality of DNA Mismatch Repair Proteins

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e31863 ◽  
Author(s):  
Angela Brieger ◽  
Guido Plotz ◽  
Inga Hinrichsen ◽  
Sandra Passmann ◽  
Ronja Adam ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Fluorescent Labeling ◽  
Dna Mismatch ◽  
Mismatch Repair Proteins

scholarly journals The Interaction of DNA Mismatch Repair Proteins with Human Exonuclease I

2001 ◽  
Vol 276 (35) ◽  
pp. 33011-33018 ◽  
Author(s):  
Christoph Schmutte ◽  
Margaret M. Sadoff ◽  
Kang-Sup Shim ◽  
Samir Acharya ◽  
Richard Fishel
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Exonuclease I ◽  
Dna Mismatch ◽  
Mismatch Repair Proteins

Characterization of the DNA mismatch repair proteins MutS and MutL in a hypermutator Acinetobacter baumannii

2017 ◽  
Vol 113 ◽  
pp. 74-84 ◽  
Author(s):  
Behnaz Deihim ◽  
Malihe Hassanzadeh ◽  
Nazanin Zahra Shafiei-Jandaghi ◽  
Massoud Amanlou ◽  
Masoumeh Douraghi
Keyword(s):  
Acinetobacter Baumannii ◽  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Dna Mismatch ◽  
Mismatch Repair Proteins
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