Reply: Lipofilling after Laser-Assisted Treatment for Facial Filler Complication: Volumetric and Regenerative Effect

AbstractThe regenerative effect of Epimedium and its major bioactive flavonoid icariin (ICA) have been documented in traditional medicine, but their effect on sarcopenia has not been evaluated. The aim of this study was to investigate the effects of Epimedium extract (EE) on skeletal muscle as represented by differentiated C2C12 cells. Here we demonstrated that EE and ICA stimulated C2C12 myotube hypertrophy by activating several, including IGF-1 signal pathways. C2C12 myotube hypertrophy was demonstrated by enlarged myotube and increased myosin heavy chains (MyHCs). In similar to IGF-1, EE/ICA activated key components of the IGF-1 signal pathway, including IGF-1 receptor. Pre-treatment with IGF-1 signal pathway specific inhibitors such as picropodophyllin, LY294002, and rapamycin attenuated EE induced myotube hypertrophy and MyHC isoform overexpression. In a different way, EE induced MHyC-S overexpression can be blocked by AMPK, but not by mTOR inhibitor. On the level of transcription, EE suppressed myostatin and MRF4 expression, but did not suppress atrogenes MAFbx and MuRF1 like IGF-1 did. Differential regulation of MyHC isoform and atrogenes is probably due to inequivalent AKT and AMPK phosphorylation induced by EE and IGF-1. These findings suggest that EE/ICA stimulates pathways partially overlapping with IGF-1 signaling pathway to promote myotube hypertrophy.

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Quality and Reliability of YouTube for Patient Information on Facial Fillers

The American Journal of Cosmetic Surgery ◽

10.1177/0748806821991408 ◽

2021 ◽

pp. 074880682199140

Author(s):

Manish J. Patel ◽

Mit M. Patel ◽

Brittany T. Abud ◽

Robert T. Cristel

Keyword(s):

Patient Education ◽

Patient Experience ◽

Average Length ◽

Dermal Filler ◽

Accurate Information ◽

Sufficient Information ◽

Inclusion Criteria ◽

Educational Value ◽

Facial Filler ◽

Source Reliability

YouTube proves to be a source of health information for patients. This is the first study to analyze the source reliability and educational value of YouTube videos on facial filler treatments. On August 12, 2020, YouTube.com was queried using the keywords “facial filler” or “dermal filler” or “fillers.” A total of 100 were initially reviewed in which 74 videos met the inclusion criteria and were included in the final analysis. Video characteristics were recorded, and each video was graded for source reliability and educational value by using the Journal of the American Medical Association (JAMA) benchmark criteria and the Global Quality Score (GQS), respectively. Furthermore, each video was assessed to determine whether there was discussion of 5 different topics that were deemed to be useful to patients prior to undergoing a facial filler treatment. A total of 74 videos met the inclusion criteria and had an average length of 436 seconds (7 minutes and 16 seconds), 146 805 views, 1906 likes, 73 dislikes, and 241 comments. Forty-five videos (61%) were posted with an intention to educate patients, whereas 29 videos (39%) were posted with an intention to describe a patient’s experience with facial filler treatment. Patient education videos were found to have a significantly higher educational value ( PGQS < .001). Patient experience videos showed no difference in reliability score ( PJAMA > .05) to patient education videos, but patient experience videos were found to have lower educational value compared with patient education videos ( PGQS < .001). In addition, both categories are not providing sufficient information for informed decision-making prior to treatment deemed by the 5 selected categories we found most informative. As patients will continue to seek educational material online, clinicians should use this information to help primarily educate patients with standardized and accurate information about their treatment.

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