scholarly journals Fine-tuning of T-cell receptor avidity to increase HIV epitope variant recognition by cytotoxic T lymphocytes

AIDS ◽  
2010 ◽  
Vol 24 (17) ◽  
pp. 2619-2628 ◽  
Author(s):  
Michael S Bennett ◽  
Aviva Joseph ◽  
Hwee L Ng ◽  
Harris Goldstein ◽  
Otto O Yang
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
T Cell Receptor ◽  
Cytotoxic T Lymphocytes ◽  
Cell Receptor ◽  
Fine Tuning ◽  
Epitope Variant

Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB

2002 ◽  
Vol 20 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Marcela V. Maus ◽  
Anna K. Thomas ◽  
Debra G.B. Leonard ◽  
David Allman ◽  
Kathakali Addya ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
T Cell Receptor ◽  
Cytotoxic T Lymphocytes ◽  
Ex Vivo ◽  
Cell Receptor ◽  
Ex Vivo Expansion

scholarly journals Exocytic responses of single leukaemic human cytotoxic T lymphocytes stimulated by agents that bypass the T cell receptor

2005 ◽  
Vol 567 (3) ◽  
pp. 891-903 ◽  
Author(s):  
Arun T. Pores-Fernando ◽  
Roslyn A. Bauer ◽  
Georjeana A. Wurth ◽  
Adam Zweifach
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
T Cell Receptor ◽  
Cytotoxic T Lymphocytes ◽  
Cell Receptor

Two forms of the T-cell receptor γ protein found on peripheral blood cytotoxic T lymphocytes

Nature ◽  
1987 ◽  
Vol 325 (6106) ◽  
pp. 689-694 ◽  
Author(s):  
Michael B. Brenner ◽  
Joanne McLean ◽  
Harriet Scheft ◽  
Janice Riberdy ◽  
Siew-Lan Ang ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
T Cell Receptor ◽  
Cytotoxic T Lymphocytes ◽  
Peripheral Blood ◽  
Cell Receptor

scholarly journals Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain.

1989 ◽  
Vol 169 (5) ◽  
pp. 1557-1564 ◽  
Author(s):  
A Wright ◽  
J E Lee ◽  
M P Link ◽  
S D Smith ◽  
W Carroll ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
B Cell ◽  
T Cell Receptor ◽  
Cytotoxic T Lymphocytes ◽  
Cell Receptor ◽  
Transformed Cells ◽  
Adoptive Therapy ◽  
Specific Antigens

CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. Here we describe the generation and properties of human CTL specific for the idiotype on autologous B cell tumors. These cells are CD3+,CD4-,CD8- and express the delta chain of the TCR. Such cells may prove useful in tumor-specific adoptive therapy.

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