Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain.
1989 ◽
Vol 169
(5)
◽
pp. 1557-1564
◽
CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. Here we describe the generation and properties of human CTL specific for the idiotype on autologous B cell tumors. These cells are CD3+,CD4-,CD8- and express the delta chain of the TCR. Such cells may prove useful in tumor-specific adoptive therapy.
2005 ◽
Vol 567
(3)
◽
pp. 891-903
◽