Differentiation of Reactive Lymph Nodes and Tumor Metastatic Lymph Nodes With 68Ga-FAPI PET/CT in a Patient With Squamous Cell Lung Cancer

Objective: This study aimed to investigate the relationship between 18Fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) parameters and hematological parameters in squamous cell lung cancer without distant metastasis and to investigate the prognostic value of these parameters. Patients and Methods: This study included 155 patients who underwent 18F-FDG PET/CT imaging for squamous cell lung cancer. Metabolic and hematological parameters were analyzed. Metabolic parameters included maximum and mean standardized uptake values (SUVmax and SUVmean), metabolic tumor volume (MTV), total lesional glycolysis (TLG), and maximum tumor-to-blood SUV ratio (SURmax). Hematological parameters included neutrophil, lymphocyte, platelet, neutrophil/lymphocyte count ratio (NLR), and platelet/lymphocyte count ratio (PLR) Results: Overall survival was significantly shorter in patients with TLG > 194, NLR > 3.3, and PLR > 157.2 (p < 0.001, p = 0.001, and p = 0.001, respectively). There was a poor correlation between TLG and NLR (p < 0.001, r = 0.302), TLG and PLR (p < 0.001, r = 0.304). TLG (> 194; hazard ratio 1.704, 95% CI 1.056–2.751, p = 0.027) and Tumor-Node-Metastasis (TNM)-based staging (stage II; hazard ratio 1.965, 95% CI 0.739–5.227, p = 0.019) were independent prognostic factors for overall survival. Conclusion: While PET/CT metabolic parameters had both predictive and independent prognostic values in squamous cell lung cancers, PLR and NLR had only predictive values. It shows that PET/CT metabolic parameters related to the course of the disease are more valuable than hematological parameters in squamous cell lung cancer.

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The Value of PD-L1 Expression in Metastatic Lymph Nodes of Advanced Non-Small Cell Lung Cancer

CHEST Journal ◽

10.1016/j.chest.2020.06.077 ◽

2020 ◽

Vol 158 (4) ◽

pp. 1785-1787 ◽

Cited By ~ 1

Author(s):

Haitang Yang ◽

Sean R.R. Hall ◽

Feng Yao

Keyword(s):

Lung Cancer ◽

Lymph Nodes ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Small Cell Lung ◽

Metastatic Lymph Nodes ◽

Metastatic Lymph

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Isolated Pancreatic Metastasis From Squamous Cell Lung Cancer Mimicking Primary Pancreatic Ductal Adenocarcinoma on FDG PET/CT

Clinical Nuclear Medicine ◽

10.1097/rlu.0000000000002986 ◽

2020 ◽

Vol 45 (5) ◽

pp. 420-422

Author(s):

Wei Zhou ◽

Hui Dong ◽

Aisheng Dong

Keyword(s):

Lung Cancer ◽

Pancreatic Ductal Adenocarcinoma ◽

Squamous Cell ◽

Cell Lung Cancer ◽

Fdg Pet ◽

Squamous Cell Lung Cancer ◽

Ductal Adenocarcinoma ◽

Pancreatic Metastasis ◽

Pet Ct ◽

Fdg Pet Ct

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Synchronous Bronchioloalveolar and Squamous Cell Lung Cancer With Different 18F-FDG Avidity on PET/CT

Clinical Nuclear Medicine ◽

10.1097/rlu.0b013e31824440f9 ◽

2012 ◽

Vol 37 (10) ◽

pp. e255-e256 ◽

Cited By ~ 4

Author(s):

Thorsten Derlin ◽

Till Sebastian Clauditz ◽

Alexander Quaas ◽

Christian Rolf Habermann

Keyword(s):

Lung Cancer ◽

Squamous Cell ◽

Cell Lung Cancer ◽

Squamous Cell Lung Cancer ◽

Pet Ct ◽

18F Fdg ◽

Fdg Avidity

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Simultaneous Integrated Boost of intensity modulated radiation therapy to Stage II-III Non-Small Cell Lung Cancer with metastatic lymph nodes

10.21203/rs.3.rs-15993/v1 ◽

2020 ◽

Author(s):

qingsong li ◽

Na Liang ◽

Wei-Wei Ouyang ◽

Sheng-Fa Su ◽

Zhu Ma ◽

...

Keyword(s):

Lung Cancer ◽

Radiation Therapy ◽

Lymph Nodes ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Stage Ii ◽

Small Cell Lung ◽

Metastatic Lymph Nodes ◽

Metastatic Lymph

Abstract Background: Local tumor failure remains a major problem after radiation-based nonsurgical treatment for unresectable locally advanced Non-Small Cell Lung Cancer （NSCLC）and inoperable stage II NSCLC .The aim of this study was to evaluate the feasibility of Simultaneous Integrated Boos of intensity modulated radiation therapy (SIB-IMRT) to Stage II-III NSCLC with metastatic lymph nodes. Methods: Patients were diagnosed by pathology or PET-CT. PTV was divide into two parts as follow, the PTV of primary tumor (PTVp) and the PTV of metastatic lymph nodes (PTVn) .The radiation doses were simultaneously prescripted 78Gy (BED = 101.48Gy) for PTVp and 60-65Gy (BED = 73.6-81.25Gy) for PTVn, 26f/ 5.2 weeks .Response was scored according to WHO criteria. Radiotherapy toxicity was scored according to RTOG criteria .Hematology and gastrointestinal toxicity were scored according to CTCAE1.0 criteria. Results: A total of 20 patients were enrolled. 17 patients were diagnosed by pathology and 3 patients were diagnosed by PET-CT . All patients were treated with SIB-IMRT. The objective response rate (ORR) was 90%, with CR 25%, PR 65%, NC 10% and PD 0%. Although Radiation toxicitiy was common, there were no grade≥3，with Radiation pneumonitis (10 cases), esophagitis (17 cases) and dermatitis (12 cases). The local control rates at 1, 3 and 5 years were 85%, 75% and 70%, respectively. The overall survival（OS）and local progression-free survival(LPFS) rates at 1, 3 and 5 years were 90%, 42.6%, 35.5% and 84.4%, 35.5% , 28.4%, respectively. The MST was 24 months. Conclusions: SIB-IMRT can significantly improve ORR and suivival for stage II-III NSCLC with metastatic lymph nodes , with high safety and satisfactory efficacy . Keywords: cancer/non-small-cell lung cancer; radiation therapy /SIB-IMRT; efficacy; safety Retrospective Trial Registration： (ChiCTR 2000029304)

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