Improved Prognostic Value of Standardized Uptake Value Corrected for Blood Glucose Level in Pancreatic Cancer Using F-18 FDG PET

2011 ◽  
Vol 36 (5) ◽  
pp. 331-336 ◽  
Author(s):  
Sang Mi Lee ◽  
Tae-Sung Kim ◽  
Jeong Won Lee ◽  
Seok-Ki Kim ◽  
Sang-Jae Park ◽  
...  
2012 ◽  
Vol 31 (4) ◽  
pp. 210-212
Author(s):  
V. Peiro Valgañon ◽  
J.C. Alonso Farto

2009 ◽  
Vol 48 (01) ◽  
pp. 44-54 ◽  
Author(s):  
R. Santer ◽  
W. Brenner ◽  
I. Apostolova ◽  
J. Mester ◽  
M. Clausen ◽  
...  

Summary Aim: FDG PET in hyperglycaemic subjects often suffers from limited statistical image quality, which may hamper visual and quantitative evaluation. In our study the following insulin bolus protocol is proposed for acute correction of hyperglycaemia (> 7.0 mmol/l) in brain FDG PET. (i) Intravenous bolus injection of short-acting insulin, one I.E. for each 0.6 mmol/l blood glucose above 7.0. (ii) If 20 min after insulin administration plasma glucose is ≤ 7.0 mmol/l, proceed to (iii). If insulin has not taken sufficient effect step back to (i). Compute insulin dose with the updated blood glucose level. (iii) Wait further 20 min before injection of FDG. (iv) Continuous supervision of the patient during the whole scanning procedure. Methods: The potential of this protocol for improvement of image quality in brain FDG PET in hyperglycaemic subjects was evaluated by computer simulations within the Sokoloff model. A plausibility check of the prediction of the computer simulations on the magnitude of the effect that might be achieved by correction of hyperglycaemia was performed by retrospective evaluation of the relation between blood glucose level and brain FDG uptake in 89 subjects in whom FDG PET had been performed for diagnosis of Alzheimer's disease. Results: The computer simulations suggested that acute correction of hyperglycaemia according to the proposed bolus insulin protocol might increase the FDG uptake of the brain by up to 80%. The magnitude of this effect was confirmed by the patient data. Conclusion: The proposed management protocol for acute correction of hyper glycaemia with insulin has the potential to significantly improve the statistical quality of brain FDG PET images. This should be confirmed in a prospective study in patients.


Pancreatology ◽  
2001 ◽  
Vol 1 (3) ◽  
pp. 224-229 ◽  
Author(s):  
Paul Georg Lankisch ◽  
Torsten Blum ◽  
Anja Bruns ◽  
Michael Dröge ◽  
Gisbert Brinkmann ◽  
...  

2011 ◽  
Vol 38 (3) ◽  
pp. 347-351 ◽  
Author(s):  
Kazuo Kubota ◽  
Hiroshige Watanabe ◽  
Yuji Murata ◽  
Masashi Yukihiro ◽  
Kimiteru Ito ◽  
...  

2019 ◽  
pp. 52-56
Author(s):  
Yu.F. Glukhov ◽  
N.V. Krutikov ◽  
A.V. Ivanov ◽  
N.P. Muravskaya

We have studied and analyzed status and metrological supervision of blood glucose monitors, individual devices for a person’s blood glucose level measurement. It has been indicated that nowadays blood glucose monitors like other individual devices for medical measurement are not allowed to be involved in telemedicine public service. This accounts for absence of metrological supervision with these measurement devices in telemedicine. In addition, the key problem is absence of safe methods and means of remote verificaition, calibration and transmission of measurement data to health care centers. The article offers a remote test method for blood glucose monitors using a number of resistors with values correlating with measured blood glucose level. The available method has been successfully trialed in real practice.


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