Signet Ring Cell Histology is an Independent Predictor of Poor Prognosis in Gastric Adenocarcinoma Regardless of Tumoral Clinical Presentation

2009 ◽  
Vol 250 (6) ◽  
pp. 878-887 ◽  
Author(s):  
Guillaume Piessen ◽  
Mathieu Messager ◽  
Emmanuelle Leteurtre ◽  
Triboulet Jean-Pierre ◽  
Christophe Mariette
Medicine ◽  
2014 ◽  
Vol 93 (27) ◽  
pp. e136 ◽  
Author(s):  
Jung Ho Shim ◽  
Kyo Young Song ◽  
Hyung-Ho Kim ◽  
Sang-Uk Han ◽  
Min-Chan Kim ◽  
...  

2007 ◽  
Vol 50 (5) ◽  
pp. 663-665 ◽  
Author(s):  
S Piña-Oviedo ◽  
L Del Valle ◽  
B de Leon-Bojorge ◽  
C Ortiz-Hidalgo

1992 ◽  
Vol 78 (3) ◽  
pp. 216-218
Author(s):  
Jose I. Lopez ◽  
Javier C. Angulo

A case of transitional cell carcinoma of the bladder displaying prominent signet-ring cell features is reported. Despite combined therapy, the patient died within a few months of the diagnosis, thus confirming the poor prognosis of this tumor. We understand this entity could be considered as an example of neoplastic-associated metaplasia and therefore propose that it should be distinguished from genuine adenocarcinoma.


IDCases ◽  
2020 ◽  
Vol 20 ◽  
pp. e00769 ◽  
Author(s):  
F. Soto-Febres ◽  
A. Morales-Moreno ◽  
J. Arenas ◽  
G. Pérez-Lazo

Surgery ◽  
2013 ◽  
Vol 154 (5) ◽  
pp. 1093-1099 ◽  
Author(s):  
Caroline Gronnier ◽  
Mathieu Messager ◽  
William B. Robb ◽  
Timothée Thiebot ◽  
Damien Louis ◽  
...  

Author(s):  
Jennifer L. Seyffert ◽  
Nathan Bibliowicz ◽  
Christopher Wong ◽  
Michael Wangia

<p>Signet ring cell appendiceal adenocarcinoma (SRCAA) is a rare entity with poor prognosis and high tendency for metastasis to pelvic lymph nodes, ovaries, and peritoneal surfaces. Despite numerous reports of intra-abdominal metastasis, there have been few reported cases of cutaneous SRCAA metastasis. We report a rare case of SRCAA metastatic to the cutaneous abdominal wall in a 67 years old female, which was first presenting sign of disease recurrence.</p>


2020 ◽  

Purpose: The present study aims to evaluate the incidence of signet ring cell (SRC) histology in patients with gastric cancer and its prognostic significance on the disease stage. Methods: Between November 2006 and September 2019, 309 patients were reviewed retrospectively in Kartal Koşuyolu High Specialization Training and Research Hospital Gastroenterology Surgery clinic in Turkey and the clinicopathological features and survival status were examined in the presence of ring cell histology. Results: Of the patients, 71.4% had gastric cancer with a non-SRC histology and 28.6% had an SRC histology. The presence of an SRC histology was found to be associated with young age (p=0.007), advanced depth of wall invasion (p=0.001), number of positive lymph nodes (p=0.022) and presence of vascular invasion (p=0.044). The presence of an SRC histology was associated with good prognosis in patients with stage I gastric cancer (p=0.045), but with poor prognosis in patients with stage III disease (p=0.034). The study found no significant association between stage II disease and overall survival. Conclusions: The present study found survival to be associated with good prognosis in stage I, and poor prognosis in stage III among patients with gastric cancer with SRC histology. No prognostic significance could be established for overall survival.


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