scholarly journals Relation Between Insulin, Insulin-related Factors, and Plasma Amyloid Beta Peptide Levels at Midlife in a Population-based Study

2012 ◽  
Vol 26 (1) ◽  
pp. 50-54 ◽  
Author(s):  
Mary K. Townsend ◽  
Olivia I. Okereke ◽  
Weiming Xia ◽  
Ting Yang ◽  
Dennis J. Selkoe ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Population Based ◽  
Amyloid Beta Peptide ◽  
Related Factors ◽  
Population Based Study ◽  
Beta Peptide

P3-030: The relation between insulin, insulin-related factors, and plasma amyloid-beta protein levels at mid-life in a large-scale population-based study

2010 ◽  
Vol 6 ◽  
pp. S457-S457
Author(s):  
Mary K. Townsend ◽  
Olivia I. Okereke ◽  
Weiming Xia ◽  
Dennis J. Selkoe ◽  
Francine Grodstein
Keyword(s):  
Amyloid Beta ◽  
Large Scale ◽  
Population Based ◽  
Amyloid Beta Protein ◽  
Related Factors ◽  
Population Based Study ◽  
Protein Levels ◽  
Scale Population

G-lymphatic, vascular and immune pathways for Aβ clearance cascade and therapeutic targets for Alzheimer’s disease

2020 ◽  
Vol 23 ◽  
Author(s):  
Saurav Chakraborty ◽  
Jyothsna ThimmaReddygari ◽  
Divakar Selvaraj
Keyword(s):  
Alzheimer Disease ◽  
Amyloid Precursor Protein ◽  
Amyloid Beta ◽  
Complement System ◽  
Therapeutic Targets ◽  
Neuronal Cell ◽  
Precursor Protein ◽  
Amyloid Beta Peptide ◽  
Beta Peptide ◽  
Immune Pathways

The Alzheimer disease is a age related neurodegenerative disease. The factors causing alzheimer disease are numerous. Research on humans and rodent models predicted various causative factors involved in Alzheimer disease progression. Among them, neuroinflammation, oxidative stress and apoptosis play a major role because of accumulation of extracellular amyloid beta peptides. Here, the clearance of amyloid beta peptide plays a major role because of the imbalance in the production and clearance of the amyloid beta peptide. Additionally, neuroinflammation by microglia, astrocytes, cytokines, chemokines and the complement system also have a major role in Alzheimer disease. The physiological clearance pathways involved in amyloid beta peptide are glymphatic, vascular and immune pathways. Amyloid precursor protein, low density lipoprotein receptor-related protein 1, receptor for advanced glycation end product, apolipoprotein E, clusterin, aquaporin 4, auto-antibodies, complement system, cytokines and microglia are involved in amyloid beta peptide clearance pathways across the blood brain barrier. The plaque formation in the brain by alternative splicing of amyloid precursor protein and production of misfolded protein results in amyloid beta agglomeration. This insoluble amyloid beta leads to neurodegenerative cascade and neuronal cell death occurs. Studies had shown disturbed sleep may be a risk factor for dementia and cognitive decline. In this review, the therapeutic targets for alzheimer disease via focussing on pathways for amyloid beta clearance are discussed.

Conformations and Biological Activities of Amyloid Beta Peptide 25-35

2009 ◽  
Vol 999 (999) ◽  
pp. 1-6 ◽  
Author(s):  
L. Millucci ◽  
L. Ghezzi ◽  
G. Bernardini ◽  
A. Santucci
Keyword(s):  
Amyloid Beta ◽  
Biological Activities ◽  
Amyloid Beta Peptide ◽  
Beta Peptide
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