Effects of theta burst stimulation on referred phantom sensations in patients with spinal cord injury

Neuroreport ◽  
2016 ◽  
Vol 27 (4) ◽  
pp. 209-212 ◽  
Author(s):  
Raffaele Nardone ◽  
Pierpaolo De Blasi ◽  
Yvonne Höller ◽  
Alexandra C. Taylor ◽  
Francesco Brigo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Cord Injury ◽  
Theta Burst

Effects of intermittent theta burst stimulation on spasticity after spinal cord injury

2017 ◽  
Vol 35 (3) ◽  
pp. 287-294 ◽  
Author(s):  
Raffaele Nardone ◽  
Patrick B. Langthaler ◽  
Andrea Orioli ◽  
Peter Höller ◽  
Yvonne Höller ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Cord Injury ◽  
Theta Burst

scholarly journals Effects of Rubber Hand Illusion and Excitatory Theta Burst Stimulation on Tactile Sensation: A Pilot Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Vanessa N. Frey ◽  
Kevin Butz ◽  
Georg Zimmermann ◽  
Alexander Kunz ◽  
Yvonne Höller ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Healthy Subjects ◽  
Tactile Sensation ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Top Down ◽  
Rubber Hand ◽  
Cord Injury ◽  
Theta Burst

Synchronous visuotactile stimulation on the own hidden hand and a visible fake limb can alter bodily self-perception and influence spontaneous neuroplasticity. The rubber hand illusion (RHI) paradigm experimentally produces an illusion of rubber hand ownership and arm shift by simultaneously stroking a rubber hand in view and a participant’s visually occluded hand. The aim of this cross-over, placebo-controlled, single-blind study was to assess whether RHI, in combination with high-frequency repetitive transcranial magnetic stimulation (rTMS) given as intermittent (excitatory) theta burst stimulation (iTBS) applied over the hand area of the primary sensory region (S1) can enhance tactile sensation in a group of 21 healthy subjects and one patient with cervical spinal cord injury. Four sessions covered all combinations of real and sham stimulations of the RHI and the TBS: real TBS and real RHI, real TBS and sham RHI, sham TBS and real RHI, and both conditions sham. The condition sham TBS and real RHI shows the greatest effect on the proprioceptive drift (median 2.3 cm, IQR 2) and on the score of RHI questionnaires (median 3, IQR 2) in the control group as well as in the real-real condition (median 2, IQR 2). The sham TBS and real RHI condition also shows the best results in the electrical perception test of the patient (median 1.9 mA). Conversely, the upregulation of the cortical excitability of S1 via TBS seems to impair the effect of the RHI. This might be due to a strengthening of the top-down connection between the central nervous system and the periphery, diminishing the RHI. This finding helps in understanding the mechanisms of top-down and bottom-up mechanisms in healthy subjects and patients with spinal cord injury. The RHI paradigm could represent an interesting therapeutic approach in improving tactile sensation and rTMS techniques could modulate these effects. Yet, further studies are needed, to examine the direction of the interaction effect of TMS and RH.

scholarly journals Intermittent theta-burst stimulation for upper-limb dysfunction and spasticity in spinal cord injury: a single-blind randomized feasibility study

Spinal Cord ◽  
2018 ◽  
Vol 56 (8) ◽  
pp. 762-768 ◽  
Author(s):  
Aref-Ali Gharooni ◽  
Krishnan Padmakumari Sivaraman Nair ◽  
Debby Hawkins ◽  
Ian Scivill ◽  
Daniel Hind ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Feasibility Study ◽  
Upper Limb ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Cord Injury ◽  
Upper Limb Dysfunction ◽  
Single Blind ◽  
Theta Burst

The effect of continuous theta burst stimulation over premotor cortex on circuits in primary motor cortex and spinal cord

2009 ◽  
Vol 120 (4) ◽  
pp. 796-801 ◽  
Author(s):  
Ying-Zu Huang ◽  
John C. Rothwell ◽  
Chin-Song Lu ◽  
JiunJie Wang ◽  
Yi-Hsin Weng ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Premotor Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst ◽  
Continuous Theta Burst Stimulation

Theta-burst stimulation of primary afferents drives long-term potentiation in the spinal cord and persistent pain via α2δ-1–bound NMDA receptors

2021 ◽  
pp. JN-RM-1968-21
Author(s):  
Yuying Huang (黄玉莹) ◽  
Shao-Rui Chen (陈少瑞) ◽  
Hong Chen (陈红) ◽  
Jing-Jing Zhou (周京京) ◽  
Daozhong Jin (金道忠) ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Nmda Receptors ◽  
Long Term Potentiation ◽  
Primary Afferents ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Term Potentiation ◽  
Theta Burst ◽  
Stimulation Of

scholarly journals Intermittent Theta Burst Stimulation Modulates Biceps Brachii Corticomotor Excitability in Individuals with Tetraplegia

2021 ◽  
Author(s):  
Neil Mittal ◽  
Blaize Majdic ◽  
Carrie Peterson
Keyword(s):  
Biceps Brachii ◽  
Motor Evoked Potentials ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Maximum Voluntary Contraction ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Clinical Trial Registration ◽  
Corticomotor Excitability ◽  
Cord Injury ◽  
Theta Burst

Abstract Background: Intermittent theta burst stimulation (iTBS) is a form of repetitive transcranial magnetic stimulation (TMS) that can increase corticomotor excitability of hand muscles in individuals with spinal cord injury (SCI). The objective of this study was to determine the effect of iTBS on the corticomotor excitability of the biceps brachii in individuals with tetraplegia.Methods: Ten individuals with low cervical SCI (C5-C8) and ten nonimpaired individuals completed three independent sessions. Motor evoked potentials (MEPs) served as our measure of corticomotor excitability and were collected before and after iTBS. MEPs were normalized by the electromyography corresponding to maximum voluntary contraction and analyzed using linear mixed effects models to determine the effect of iTBS (active or sham) on normalized MEPs (nMEPs). iTBS effects were compared to a ratio of active and resting motor thresholds as a measurement of corticomotor conductance potential.Results: Relative to sham, active iTBS increased nMEPs over time (p < 0.001) in individuals with SCI, but not nonimpaired individuals (p = 0.915). The amplitude of nMEPs were correlated with the biceps corticomotor conductance potential (p < 0.001), with nMEPs decreasing as the ratio increased at different rates after sham or active iTBS.Conclusions: Preliminary results suggest that iTBS increases biceps corticomotor excitability in individuals with tetraplegia with effects that may be predicted by corticomotor conductance potential. Clinical Trial Registration: NCT03277521 Registered on clinicaltrials.gov on August 24, 2017.

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