Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder

2009 ◽  
Vol 19 (3) ◽  
pp. 142-146 ◽  
Author(s):  
Siobhan Roche ◽  
Patrick McKeon
Keyword(s):  
Affective Disorder ◽  
Tryptophan Hydroxylase ◽  
Bipolar Affective Disorder ◽  
Susceptibility Gene ◽  
Tryptophan Hydroxylase 2

Further immunohistochemical characterization of BRD1 a new susceptibility gene for schizophrenia and bipolar affective disorder

2009 ◽  
Vol 214 (1) ◽  
pp. 37-47 ◽  
Author(s):  
Carsten Reidies Bjarkam ◽  
Thomas J. Corydon ◽  
Inger Marie L. Olsen ◽  
Jonatan Pallesen ◽  
Mette Nyegaard ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Susceptibility Gene

Refinement of chromosome 3p22.3 region and identification of a susceptibility gene for bipolar affective disorder

2012 ◽  
Vol 162 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Rodrigo Secolin ◽  
Claudio E.M. Banzato ◽  
Lucas F.B. Mella ◽  
Marilza L. Santos ◽  
Paulo Dalgalarrondo ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Susceptibility Gene

Tryptophan hydroxylase 2 in seasonal affective disorder: underestimated perspectives?

2015 ◽  
Vol 26 (6) ◽  
Author(s):  
Alexander V. Kulikov ◽  
Nina K. Popova
Keyword(s):  
Affective Disorder ◽  
Tryptophan Hydroxylase ◽  
Seasonal Affective Disorder ◽  
Recurrent Depression ◽  
Tryptophan Hydroxylase 2 ◽  
System Functioning ◽  
Brain Neurotransmitter ◽  
The Relationship ◽  
Rate Limiting ◽  
The Brain

AbstractSeasonal affective disorder (SAD) is characterized by recurrent depression occurring generally in fall/winter. Numerous pieces of evidence indicate the association of SAD with decreased brain neurotransmitter serotonin (5-HT) system functioning. Tryptophan hydroxylase 2 (TPH2) is the key and rate-limiting enzyme in 5-HT synthesis in the brain. This paper concentrates on the relationship between TPH2 activity and mood disturbances, the association between human

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