Tension responses to increased hydrostatic pressure in glycerinated rabbit psoas muscle fibres

1987 ◽  
Vol 232 (1267) ◽  
pp. 217-226 ◽  
Keyword(s):  
Hydrostatic Pressure ◽  
Muscle Fibre ◽  
Room Temperature ◽  
Psoas Muscle ◽  
Isometric Tension ◽  
Muscle Fibres ◽  
Single Muscle Fibre ◽  
Rabbit Psoas ◽  
Rigor Tension ◽  
Tension Transducer

A method developed to study the effect of increased hydrostatic pressure on the isometric tension of a single muscle fibre is described and experiments done at room temperature (18–22°C) on glycerinated rabbit psoas muscle fibres are presented. Increase of pressure (range 1–10 MPa) caused little change in tension transducer response when a muscle fibre was relaxed. However, there was a reversible depression of isometric tension with an increase of pressure when a fibre was maximally calcium-activated or in rigor; the depression was around 15% for active tension and 30% for rigor tension, for an increase of pressure of 10 MPa ( ca . 100 atm).

scholarly journals Reversal of the cross-bridge force-generating transition by photogeneration of phosphate in rabbit psoas muscle fibres.

1992 ◽  
Vol 451 (1) ◽  
pp. 247-278 ◽  
Author(s):  
J A Dantzig ◽  
Y E Goldman ◽  
N C Millar ◽  
J Lacktis ◽  
E Homsher
Keyword(s):  
Psoas Muscle ◽  
Muscle Fibres ◽  
Rabbit Psoas ◽  
Cross Bridge ◽  
The Cross

scholarly journals The Length of Cooperative Units on the Thin Filament in Rabbit Psoas Muscle Fibres

2002 ◽  
Vol 87 (6) ◽  
pp. 691-697 ◽  
Author(s):  
Wei Ding ◽  
Hideaki Fujita ◽  
Masataka Kawai
Keyword(s):  
Thin Filament ◽  
Psoas Muscle ◽  
Muscle Fibres ◽  
Rabbit Psoas ◽  
Cooperative Units

BDM affects nucleotide binding and force generation steps of the cross-bridge cycle in rabbit psoas muscle fibers

1994 ◽  
Vol 266 (2) ◽  
pp. C437-C447 ◽  
Author(s):  
Y. Zhao ◽  
M. Kawai
Keyword(s):  
Equilibrium Constants ◽  
Muscle Fibers ◽  
Psoas Muscle ◽  
Isometric Tension ◽  
Activation Mechanism ◽  
Phosphate Binding ◽  
Rabbit Psoas ◽  
Cross Bridge ◽  
The Cross ◽  
Cross Bridges

The effect of 2,3-butanedione monoxime (BDM) on elementary steps of the cross-bridge cycle was studied with the sinusoidal analysis technique in skinned rabbit psoas muscle fibers. Our results showed that isometric tension and stiffness decreased progressively with an increase in the BDM concentration. The MgATP and MgADP binding constants increased 27 and 6 times, respectively, when BDM was increased from 0 to 18 mM, whereas the phosphate binding constant did not change significantly. The equilibrium constants of the ATP isomerization and detachment step were not sensitive to BDM, whereas the equilibrium constant of the attachment (power stroke) step decreased with BDM. Thus, in the presence of BDM, the number of attached cross bridges decreases; more cross bridges accumulate in the detached state, causing isometric tension and stiffness to decline. However, our detailed analysis shows that the decrease in the number of attached cross bridges is approximately 40%, which is not adequate to account for the 84% decrease in the isometric tension when 18 mM BDM was present. Therefore we suggest that a thin-filament activation mechanism is also affected by BDM.

scholarly journals Effect of active shortening on the rate of ATP utilisation by rabbit psoas muscle fibres

2001 ◽  
Vol 531 (3) ◽  
pp. 781-791 ◽  
Author(s):  
Y.‐B. Sun ◽  
K. Hilber ◽  
M. Irving
Keyword(s):  
Psoas Muscle ◽  
Muscle Fibres ◽  
Rabbit Psoas

Age-related Changes in Motor Function (I). Mechanical and Neuromuscular Factors

2020 ◽  
Author(s):  
Rui Wu ◽  
Giuseppe De Vito ◽  
Eamonn Delahunt ◽  
Massimiliano Ditroilo
Keyword(s):  
Neuromuscular Junction ◽  
Muscle Fibre ◽  
Muscle Quality ◽  
Muscle Fibres ◽  
Type I ◽  
Single Muscle Fibre ◽  
Fascicle Length ◽  
Functional Changes ◽  
Collateral Sprouting ◽  
Age Related

AbstractThis two-part narrative review aims to provide an insight into the age-related mechanical and neuromuscular factors contributing to: (1) decreased maximal muscle strength and power; (2) decreased force control; and (3) increased fatigability. Structural and functional changes from the macro-level of the muscle-tendon unit to the micro-level of the single muscle fibre have been reviewed and are described. At the muscle-tendon unit level, muscle volume, thickness and cross-sectional area, as well as pennation angle and fascicle length all decrease as part of the natural ageing process. These changes negatively affect muscle quality, muscle and tendon stiffness and Young’s modulus and account for impairment in motor performance. A progressive age-related alteration in neuromuscular function is also well-established, with reduction in number and firing rate of the motor unit, contractile velocity and specific tension of muscle fibres, and stability of neuromuscular junction. These could be the result of structural alterations in the: (i) motor neuron, with number reduced, size and collateral sprouting increased; (ii) neuromuscular junction, with decreased post-synaptic junctional fold and density of active zones and increased pre-synaptic branching and post-synaptic area; and (iii) muscle fibre, with decreased number and size and increased type I and co-expression of myosin heavy chain.

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