On the voltage dependence of inactivation in the sodium channel of the squid giant axon

1991 ◽  
Vol 243 (1306) ◽  
pp. 47-53 ◽  
Keyword(s):  
Sodium Channel ◽  
Voltage Dependence ◽  
Giant Axon ◽  
Squid Giant Axon

scholarly journals Inhibitory effects of myrmicacin on the sodium channel in the squid giant axon.

1981 ◽  
Vol 57 (8) ◽  
pp. 314-317 ◽  
Author(s):  
Toshifumi TAKENAKA ◽  
Hidenori HORIE ◽  
Hideaki HORI ◽  
Tohru YOSHIOKA ◽  
Yozo IWANAMI
Keyword(s):  
Sodium Channel ◽  
Giant Axon ◽  
Squid Giant Axon ◽  
Inhibitory Effects

scholarly journals Analysis of sodium current fluctuations in the cut-open squid giant axon.

1984 ◽  
Vol 83 (2) ◽  
pp. 133-142 ◽  
Author(s):  
I Llano ◽  
F Bezanilla
Keyword(s):  
Sodium Channel ◽  
Sodium Channels ◽  
Sodium Current ◽  
Giant Axon ◽  
Squid Giant Axon ◽  
Statistical Techniques ◽  
Current Fluctuations ◽  
Small Populations ◽  
Squid Axon ◽  
Single Sodium Channel

Patch pipettes were used to record the current arising from small populations of sodium channels in voltage-clamped cut-open squid axons. The current fluctuations associated with the time-variant sodium conductance were analyzed with nonstationary statistical techniques in order to obtain an estimate for the conductance of a single sodium channel. The results presented support the notion that the open sodium channel in the squid axon has only one value of conductance, 3.5 pS.

Conduction velocity and gating current in the squid giant axon

1975 ◽  
Vol 189 (1094) ◽  
pp. 81-86 ◽  
Keyword(s):  
Sodium Channel ◽  
Conduction Velocity ◽  
Charged Particles ◽  
Giant Axon ◽  
Squid Giant Axon ◽  
Gating Current ◽  
Giant Axons ◽  
Sodium Conductance ◽  
Conduction Velocities

As predicted by Hodgkin (1975), calculation of conduction velocities in squid giant axons shows that if each sodium channel is gated by charged particles moving in the membrane field there will be a maximum in the relation between sodium conductance and conduction velocity.

The relationship between the inactivating fraction of the asymmetry current and gating of the sodium channel in the squid giant axon

1982 ◽  
Vol 215 (1200) ◽  
pp. 391-404 ◽  
Keyword(s):  
Conformational Changes ◽  
Voltage Dependence ◽  
Ionic Currents ◽  
Giant Axon ◽  
Quantitative Comparison ◽  
Squid Giant Axon ◽  
Relative Timing ◽  
Sodium System ◽  
Opening And Closing ◽  
The Relationship

A quantitative comparison between the voltage dependence of the inactivating component of the asymmetrical charge transfer in the squid giant axon and that of the sodium conductance indicates that activation of the sodium system involves either three subunits operating in parallel or a three-step series mechanism. This is confirmed by an examination of the relative timing of the flow of asymmetry and ionic currents during the opening and closing of the sodium channels. In agreement with previous suggestions, inactivation is coupled sequentially to activation. The evidence appears to argue against a trimeric system with three wholly independent subunits and favours a monomeric system that undergoes a complex sequence of conformational changes.

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