scholarly journals Functional analysis of the flagellar genes in the fliD operon of Salmonella typhimurium

Microbiology ◽  
1995 ◽  
Vol 141 (7) ◽  
pp. 1715-1722 ◽  
Author(s):  
T. Yokoseki ◽  
K. Kutsukake ◽  
K. Ohnishi ◽  
T. lino
Keyword(s):  
Functional Analysis ◽  
Salmonella Typhimurium ◽  
Flagellar Genes

scholarly journals New unified nomenclature for the flagellar genes of Escherichia coli and Salmonella typhimurium.

1988 ◽  
Vol 52 (4) ◽  
pp. 533-535 ◽  
Author(s):  
T Iino ◽  
Y Komeda ◽  
K Kutsukake ◽  
R M Macnab ◽  
P Matsumura ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Salmonella Typhimurium ◽  
Flagellar Genes

scholarly journals New unified nomenclature for the flagellar genes of Escherichia coli and Salmonella typhimurium.

1988 ◽  
Vol 52 (4) ◽  
pp. 533-535 ◽  
Author(s):  
T Iino ◽  
Y Komeda ◽  
K Kutsukake ◽  
R M Macnab ◽  
P Matsumura ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Salmonella Typhimurium ◽  
Flagellar Genes

Operon structure of flagellar genes in Salmonella typhimurium

1988 ◽  
Vol 214 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Kazuhiro Kutsukake ◽  
Yoshikazu Ohya ◽  
Shigeru Yamaguchi ◽  
Tetsuo Iino
Keyword(s):  
Salmonella Typhimurium ◽  
Operon Structure ◽  
Flagellar Genes

scholarly journals Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice

2007 ◽  
Vol 204 (12) ◽  
pp. 2949-2961 ◽  
Author(s):  
Marie-France Roy ◽  
Noémie Riendeau ◽  
Christian Bédard ◽  
Pierre Hélie ◽  
Gundula Min-Oo ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Environmental Factors ◽  
Blood Cell ◽  
Salmonella Typhimurium ◽  
Pyruvate Kinase ◽  
Susceptibility Loci ◽  
Plasmodium Chabaudi ◽  
Pyruvate Kinase Deficiency ◽  
Peak Parasitemia ◽  
Mouse Response

The mouse response to acute Salmonella typhimurium infection is complex, and it is under the influence of several genes, as well as environmental factors. In a previous study, we identified two novel Salmonella susceptibility loci, Ity4 and Ity5, in a (AcB61 × 129S6)F2 cross. The peak logarithm of odds score associated with Ity4 maps to the region of the liver and red blood cell (RBC)–specific pyruvate kinase (Pklr) gene, which was previously shown to be mutated in AcB61. During Plasmodium chabaudi infection, the Pklr mutation protects the mice against this parasite, as indicated by improved survival and lower peak parasitemia. Given that RBC defects have previously been associated with resistance to malaria and susceptibility to Salmonella, we hypothesized that Pklr is the gene underlying Ity4 and that it confers susceptibility to acute S. typhimurium infection in mice. Using a fine mapping approach combined with complementation studies, comparative studies, and functional analysis, we show that Pklr is the gene underlying Ity4 and that it confers susceptibility to acute S. typhimurium infection in mice through its effect on the RBC turnover and iron metabolism.

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