scholarly journals In vitro activity of 12 antimicrobial peptides against Mycobacterium tuberculosis and Mycobacterium avium clinical isolates

2019 ◽  
Vol 68 (2) ◽  
pp. 211-215 ◽  
Author(s):  
Elena Portell-Buj ◽  
Andrea Vergara ◽  
Izaskun Alejo ◽  
Alexandre López-Gavín ◽  
Maria Rosa Monté ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Antimicrobial Peptides ◽  
Mycobacterium Avium ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
In Vitro Activity

scholarly journals In Vitro Activity of Rifamycin Derivatives against Nontuberculous Mycobacteria, Including Macrolide- and Amikacin-Resistant Clinical Isolates

2021 ◽  
Vol 65 (5) ◽  
Author(s):  
Dae Hun Kim ◽  
Su-Young Kim ◽  
Hee Jae Huh ◽  
Nam Yong Lee ◽  
Won-Jung Koh ◽  
...  
Keyword(s):  
Mycobacterium Avium ◽  
Nontuberculous Mycobacteria ◽  
Therapeutic Option ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
Drug Resistant ◽  
In Vitro Activity ◽  
Content Type ◽  
Resistant Disease

ABSTRACT We evaluated the in vitro activity of rifamycin derivatives, including rifampin, rifapentine, rifaximin, and rifabutin, against clinical nontuberculous mycobacteria (NTM) isolates. Of the rifamycin derivatives, rifabutin showed the lowest MICs against all NTM species, including Mycobacterium avium complex, M. abscessus, and M. kansasii. Rifabutin also had effective in vitro activity against macrolide- and aminoglycoside-resistant NTM isolates. Rifabutin could be worth considering as a therapeutic option for NTM disease, particularly drug-resistant disease.

scholarly journals In Vitro Activity of Bedaquiline and Delamanid against Nontuberculous Mycobacteria, Including Macrolide-Resistant Clinical Isolates

2019 ◽  
Vol 63 (8) ◽  
Author(s):  
Dae Hun Kim ◽  
Byung Woo Jhun ◽  
Seong Mi Moon ◽  
Su-Young Kim ◽  
Kyeongman Jeon ◽  
...  
Keyword(s):  
Mycobacterium Avium ◽  
Nontuberculous Mycobacteria ◽  
Mycobacterium Abscessus ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
In Vitro Activity ◽  
Mycobacterium Kansasii ◽  
Antimicrobial Drugs ◽  
Content Type

ABSTRACT We evaluated the in vitro activities of the antimicrobial drugs bedaquiline and delamanid against the major pathogenic nontuberculous mycobacteria (NTM). Delamanid showed high MIC values for all NTM except Mycobacterium kansasii. However, bedaquiline showed low MIC values for the major pathogenic NTM, including Mycobacterium avium complex, Mycobacterium abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. kansasii. Bedaquiline also had low MIC values with macrolide-resistant NTM strains and warrants further investigation as a potential antibiotic for NTM treatment.

scholarly journals In Vitro Activities of Six Fluoroquinolones against 250 Clinical Isolates of Mycobacterium tuberculosisSusceptible or Resistant to First-Line Antituberculosis Drugs

2000 ◽  
Vol 44 (9) ◽  
pp. 2567-2568 ◽  
Author(s):  
María Jesús Ruiz-Serrano ◽  
Luis Alcalá ◽  
Lucía Martínez ◽  
Marisol Díaz ◽  
Mercedes Marín ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
Good Activity ◽  
In Vitro Activity ◽  
First Line ◽  
Antituberculosis Drugs

ABSTRACT Two hundred fifty isolates of Mycobacterium tuberculosis were evaluated for susceptibility to ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin, and gemifloxacin (SB-265805). Levofloxacin, ciprofloxacin, and grepafloxacin showed the greatest activity (MIC for 90% of strains tested [MIC90] 1 μg/ml), although ofloxacin also showed good activity, with an MIC90 of 2 μg/ml. Trovafloxacin and gemifloxacin showed lower in vitro activity, with MIC90s of 64 and 8 μg/ml, respectively.

scholarly journals In vitro activity of the antimicrobial peptides human and rabbit defensins and porcine leukocyte protegrin against Mycobacterium tuberculosis.

1996 ◽  
Vol 64 (3) ◽  
pp. 926-932 ◽  
Author(s):  
Y Miyakawa ◽  
P Ratnakar ◽  
A G Rao ◽  
M L Costello ◽  
O Mathieu-Costello ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Antimicrobial Peptides ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals Enhanced in vitro activity of pyrimethamine in combination with dapsone against Mycobacterium avium complex.

1996 ◽  
Vol 40 (10) ◽  
pp. 2426-2427 ◽  
Author(s):  
L M Shah ◽  
S C Meyer ◽  
M H Cynamon
Keyword(s):  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
In Vitro Activity ◽  
Enhanced Activity ◽  
Fixed Concentration ◽  
Broth Dilution

The in vitro activities of pyrimethamine and dapsone alone and in combination were evaluated against 23 clinical isolates of Mycobacterium avium complex. The broth dilution MICs of dapsone and pyrimethamine alone ranged from 16 to > 64 micrograms/ml. Pyrimethamine in combination with a fixed concentration of dapsone at 0.5 microgram/ml showed enhanced activity, with an MIC range of 0.5 to 16 micrograms/ml.

scholarly journals In Vitro Activities of Linezolid against Clinical Isolates of Mycobacterium tuberculosis That Are Susceptible or Resistant to First-Line Antituberculous Drugs

2003 ◽  
Vol 47 (1) ◽  
pp. 416-417 ◽  
Author(s):  
Luis Alcalá ◽  
María Jesús Ruiz-Serrano ◽  
Cristina Pérez-Fernández Turégano ◽  
Darío García de Viedma ◽  
Marisol Díaz-Infantes ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Test Methods ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
In Vitro Activity ◽  
First Line ◽  
Antituberculous Drugs ◽  
Proportion Method

ABSTRACT We evaluated 117 isolates of Mycobacterium tuberculosis for susceptibility to linezolid by the proportion and E-test methods. Linezolid showed high in vitro activity, with all the strains inhibited by ≤1 μg of the drug per ml. E-test MICs were at least 4 dilutions lower than their equivalents by the standard proportion method.

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