scholarly journals Heterogeneity of hepatitis C virus genotype 4 strains circulating in south-western France

2005 ◽  
Vol 86 (1) ◽  
pp. 107-114 ◽  
Author(s):  
Florence Nicot ◽  
Florence Legrand-Abravanel ◽  
Karine Sandres-Saune ◽  
Anne Boulestin ◽  
Martine Dubois ◽  
...  

Hepatitis C virus (HCV) is a major cause of liver disease. Knowledge of HCV variability is crucial for clinical and epidemiological analysis. HCV genotype 4 (HCV-4) has become increasingly prevalent in European countries, including France, in recent years. The present study investigates the heterogeneity of HCV-4 in south-western France by phylogenetic analysis of NS5B sequences from 166 patients. The E2 region of 90 strains was also analysed. Genotype 4 accounts for 7·4 % of HCV infections in this area. Analysis of the NS5B region revealed 12 subtypes and the NS5B and E2 phylogeny data were congruent, except for one strain. The epidemiological data indicated two main groups of patients. One included intravenous drug users (IVDUs) of French origin, who were infected by homogeneous strains of subtypes 4a or 4d. The second group comprised non-IVDU patients who were infected with heterogeneous strains. This group was subdivided into patients of French origin, who were infected with eight subtypes, and patients from non-European countries (Central Africa or the Middle East), who were mainly infected with 4f, 4k, 4r and other subtypes; they showed the greatest genetic heterogeneity. This study of a large cohort of patients shows the great diversity of HCV-4 strains, and that these subtypes have spread differently.

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e82598 ◽  
Author(s):  
Zhihui Zhang ◽  
Yufeng Yao ◽  
Wenlong Wu ◽  
Ruilin Feng ◽  
Zhongxiang Wu ◽  
...  

1994 ◽  
Vol 75 (9) ◽  
pp. 2393-2398 ◽  
Author(s):  
L.-Z. Xu ◽  
D. Larzul ◽  
E. Delaporte ◽  
C. Brechot ◽  
D. Kremsdorf

2008 ◽  
Vol 80 (4) ◽  
pp. 615-618 ◽  
Author(s):  
S. Chlabicz ◽  
R. Flisiak ◽  
O. Kowalczuk ◽  
A. Wiercińska-Drapalo ◽  
B. Pytel-Krolczuk ◽  
...  

2007 ◽  
Vol 88 (11) ◽  
pp. 2985-2990 ◽  
Author(s):  
Fatma Hmaied ◽  
Florence Legrand-Abravanel ◽  
Florence Nicot ◽  
Natalie Garrigues ◽  
Sabine Chapuy-Regaud ◽  
...  

Hepatitis C virus genotype 4 (HCV-4) is very common in central Africa, prevalent in the Middle East, and is becoming increasingly frequent among southern Europeans. We have determined the complete nucleotide sequences of HCV-4f strains and investigated their phylogenetic relationships with other genotypes. We amplified the complete genome of two HCV subtype 4f strains, IFBT84 and IFBT88. The HCV-4f strains have a total of 9181 and 9304 nt, respectively, including the 5′ untranslated region followed by a single open reading frame. There was no evidence of genomic recombination in the IFBT84 and IFBT88 strains. The sequences of the HCV-4f strain genomes are closer to those of HCV-1b than to genotypes 2, 3, 5 and 6. It is important to know the full-length sequences of HCV-4 subtypes in order to classify them correctly and to obtain more detailed knowledge about HCV epidemiology and sensitivity to interferon.


1990 ◽  
Vol 153 (5) ◽  
pp. 274-276 ◽  
Author(s):  
James Bell ◽  
Robert G Batey ◽  
Geoffrey C Farrell ◽  
Evelyn B Crewe ◽  
Anthony L Cunningham ◽  
...  

2018 ◽  
Vol 120 (5) ◽  
pp. 8154-8159 ◽  
Author(s):  
Nashwa El‐Khazragy ◽  
Naglaa El Sayed ◽  
Ahmed M. Salem ◽  
Nahla S. Hassan ◽  
Amal Tohamy Abdelmoeaz ◽  
...  

2018 ◽  
Vol 4 (3) ◽  
pp. 191-196 ◽  
Author(s):  
Abel Abdel-Moneim ◽  
Alaa Abood ◽  
Mohamed Abdel-Gabaar ◽  
Mohamed I. Zanaty ◽  
Mohamed Ramadan

2010 ◽  
Vol 82 (10) ◽  
pp. 1647-1654 ◽  
Author(s):  
Christine Larsen ◽  
Vanina Bousquet ◽  
Elisabeth Delarocque-Astagneau ◽  
Corinne Pioche ◽  
Françoise Roudot-Thoraval

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