scholarly journals Ovarian Abnormalities in the Staggerer Mutant Mouse

2005 ◽  
Vol 5 ◽  
pp. 661-664 ◽  
Author(s):  
Jean-Marie Guastavino ◽  
Salima Boufares ◽  
Wim E. Crusio
Keyword(s):  
Mutant Mouse ◽  
Pleiotropic Effect ◽  
Reproductive Efficiency ◽  
Cerebellar Mutant

Disturbances in several reproductive functions of the staggerer cerebellar mutant mouse have been observed. In this study, reproductive efficiency ofstaggerermice was compared to normal mice by recording the number of pups produced and the number of oocytes occurring. It was found thatstaggerermothers produced smaller litters than controls and the number of oocytes produced in their ovaries was reduced by thestaggerermutation. These results indicate a pleiotropic effect on fertility of the Rorasggene underlying the cerebellar abnormalities of thestaggerermutant.

Retinal degeneration in thepcd cerebellar mutant mouse. I. Light microscopic and autoradiographio analysis

1982 ◽  
Vol 212 (3) ◽  
pp. 217-230 ◽  
Author(s):  
Matthew M. LaVail ◽  
Janet C. Blanks ◽  
Richard J. Mullen
Keyword(s):  
Retinal Degeneration ◽  
Mutant Mouse ◽  
Cerebellar Mutant

Evaluating the Proposed Mechanism by Which Atorvastatin Can Protect Renal Tissue against Contrast Media: An Animal study

2019 ◽  
pp. 75-84
Keyword(s):  
Contrast Media ◽  
Kidney Injury ◽  
Saline Group ◽  
Pleiotropic Effect ◽  
Renal Tissue ◽  
Male Rats ◽  
Dependent Manner ◽  
Group 2 ◽  
Dose Dependent ◽  
Media Group

Contrast- induced nephropathy (CIN) is an elevation of serum creatinine of ≥ 0.5 mg/dL from baseline after two to three days of exposure to contrast substance if there is no other cause for acute kidney injury. Atorvastatin may protect normal kidney physiology from contrast- induced kidney injury by effects unrelated to hypolipidemia termed pleiotropic effect by decline of endothelin production, angiotensin system down regulation, and under expression of endothelial adhesion molecules. This study was conducted to assess the strategy by which atorvastatin can achieve protective effect for kidneys after exposure to contrast media in an animal model. A 40 male rats were distributed randomly into 4 groups; ten rats for each: group (1): given normal saline; group (2): CIN group given iopromide as contrast media; group (3): given atorvastatin (20mg/kg) and iopromide; and group (4): given atorvastatin (40mg/kg) and iopromide. Blood collected by cardiac puncture for detection of serum glutathione, malondialdehyde, matrix metalloproteinase-9, and interleukin-18. The results have shown a significant increase in inflammatory and oxidative stress markers in contrast media group, and significant reduction in these markers in atorvastatin treated groups, in a dose-dependent manner. As conclusion, atorvastatin mechanism for protection against CIN in a dose-dependent manner can mediate by anti-inflammatory and antioxidant effects.

Fluctuation of Reproductive Efficiency Traits of Holstein Cows in the Tokachi Area, Hokkaido

1982 ◽  
Vol 53 (12) ◽  
pp. 792-796
Author(s):  
Yoshinori TERAWAKI ◽  
Koji MUTO ◽  
Hitoshi ONO
Keyword(s):  
Holstein Cows ◽  
Reproductive Efficiency
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